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S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. |
2018 |
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Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). |
2018 |
Life Sci. |
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2018 |
Cell. Physiol. Biochem. |
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S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. |
2018 |
Science |
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Sphingolipid metabolism in cancer signalling and therapy. |
2018 |
Nat. Rev. Cancer |
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
2017 |
Blood |
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A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. |
2017 |
Inflamm. Res. |
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Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. |
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Ann Biomed Eng |
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2017 |
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S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. |
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J. Lipid Res. |
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Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
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Respirology |
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2017 |
Eur. J. Clin. Invest. |
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Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
2017 |
Med Res Rev |
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An engineered S1P chaperone attenuates hypertension and ischemic injury. |
2017 |
Sci Signal |
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S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. |
2017 |
Mediators Inflamm. |
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Acid ceramidase confers radioresistance to glioblastoma cells. |
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Oncol. Rep. |
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2017 |
J. Recept. Signal Transduct. Res. |
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Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
2017 |
J. Mol. Cell. Cardiol. |
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Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. |
2017 |
Cell Death Dis |
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Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
2017 |
Bone |
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Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
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Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
2017 |
Front Immunol |
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Targeting sphingosine-1-phosphate signaling for cancer therapy. |
2017 |
Sci China Life Sci |
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Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. |
2017 |
PLoS ONE |
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Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
2017 |
Hum. Mutat. |
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Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. |
2017 |
Clin. Chim. Acta |
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Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
2017 |
Shock |
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The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
2017 |
PLoS ONE |
pmid:28493876
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
2017 |
Clin. Cancer Res. |
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2017 |
Crit. Rev. Biochem. Mol. Biol. |
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Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. |
2017 |
J. Immunol. |
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High-Density Lipoprotein Regulation of Mitochondrial Function. |
2017 |
Adv. Exp. Med. Biol. |
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Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. |
2017 |
J. Am. Acad. Dermatol. |
pmid:28551069
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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. |
2017 |
Nature |
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A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |
2017 |
Dev. Cell |
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Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. |
2017 |
Expert Opin. Ther. Targets |
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Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. |
2017 |
J. Steroid Biochem. Mol. Biol. |
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Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. |
2017 |
Eur. J. Immunol. |
pmid:28198542
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Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. |
2017 |
Biochim. Biophys. Acta |
pmid:28188805
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Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. |
2017 |
J. Lipid Res. |
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ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. |
2017 |
J. Physiol. Biochem. |
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HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. |
2017 |
Lipids Health Dis |
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Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
2017 |
Hum. Mol. Genet. |
pmid:28175299
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Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
2017 |
Diabetes |
pmid:28174291
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Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. |
2017 |
Am. J. Physiol., Cell Physiol. |
pmid:28148497
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The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
2017 |
Aging Cell |
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