Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Niemann-Pick Disease, Type C D052556 1 associated lipids
Farber Lipogranulomatosis D055577 1 associated lipids
Tachycardia, Sinus D013616 2 associated lipids
Sensation Disorders D012678 2 associated lipids
Ileus D045823 3 associated lipids
Adenomatous Polyps D018256 4 associated lipids
Fabry Disease D000795 4 associated lipids
Hematologic Neoplasms D019337 4 associated lipids
Shock, Hemorrhagic D012771 4 associated lipids
Ovarian Diseases D010049 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Authors Title Published Journal PubMed Link
Peest U et al. S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake. 2008 J. Cell. Biochem. pmid:18172856
Liu Q et al. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. 2008 Blood pmid:17761520
Kimura T et al. Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. 2008 J. Immunol. pmid:18981156
Stradner MH et al. Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes. 2008 Osteoarthr. Cartil. pmid:17703957
Wacker BK et al. Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate. 2008 Biophys. J. pmid:17827231
Provençal M et al. Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins. 2008 Thromb. Haemost. pmid:18327407
Beyer T and Meyer-Hermann M Mechanisms of organogenesis of primary lymphoid follicles. 2008 Int. Immunol. pmid:18334502
Sensken SC et al. Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate. 2008 Cell. Signal. pmid:18313900
Kunisawa J et al. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. 2008 Blood pmid:18292290
Park HY et al. K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. 2008 Exp. Dermatol. pmid:18341573
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Malchinkhuu E et al. S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. 2008 Biochem. Biophys. Res. Commun. pmid:18088600
Meacci E et al. Sphingosine kinase activity is required for myogenic differentiation of C2C12 myoblasts. 2008 J. Cell. Physiol. pmid:17654519
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Li QF et al. Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. 2008 Biochem. Biophys. Res. Commun. pmid:18423379
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Miller AV et al. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. 2008 Mol. Cell. Biol. pmid:18426913
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Eskan MA et al. TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells. 2008 Eur. J. Immunol. pmid:18395849
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Arce FT et al. Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. 2008 Biophys. J. pmid:18408039
Goetzl EJ et al. Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity. 2008 Biochim. Biophys. Acta pmid:18381082
Hong JH et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. 2008 J. Invest. Dermatol. pmid:18385762
Lebman DA and Spiegel S Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. 2008 J. Lipid Res. pmid:18387885
Nishiuma T et al. Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18359884
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Chung FY et al. Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. 2008 Arch. Pharm. Res. pmid:19023540
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Pasquaré SJ et al. Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments. 2008 Neurochem. Res. pmid:18288612
Jiang H et al. Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices. 2008 FASEB J. pmid:18272655
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Szczepaniak WS et al. Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. 2008 Transl Res pmid:19010292
Rivera-Lopez CM et al. Lysophosphatidic acid (LPA) and angiogenesis. 2008 Angiogenesis pmid:18504643
Serebrov VY et al. Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis. 2008 Bull. Exp. Biol. Med. pmid:19513367
Li MH et al. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. 2008 Mol. Cancer Res. pmid:18922980
Devine KM et al. S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. 2008 Gynecol. Oncol. pmid:18513786
Balthasar S et al. Interactions between sphingosine-1-phosphate and vascular endothelial growth factor signalling in ML-1 follicular thyroid carcinoma cells. 2008 Endocr. Relat. Cancer pmid:18509004
Kohno T and Igarashi Y Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P. 2008 Genes Cells pmid:18513330
Miron VE et al. FTY720 modulates human oligodendrocyte progenitor process extension and survival. 2008 Ann. Neurol. pmid:17918267
Harvey KA et al. Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. 2008 Br. J. Nutr. pmid:17925051
Takashima S et al. G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. 2008 Cardiovasc. Res. pmid:18480127
Yatomi Y Plasma sphingosine 1-phosphate metabolism and analysis. 2008 Biochim. Biophys. Acta pmid:17980708
Rivera R and Chun J Biological effects of lysophospholipids. 2008 Rev. Physiol. Biochem. Pharmacol. pmid:18481029
Jang S et al. Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress. 2008 Neurochem. Res. pmid:17940874
Bu S et al. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. 2008 J. Biol. Chem. pmid:18482992
Gavrilovskaya IN et al. Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability. 2008 J. Virol. pmid:18367532
Zanin M et al. Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. 2008 Am. J. Physiol., Cell Physiol. pmid:17942639
Tölle M et al. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18483405
Huang YT et al. Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn. 2008 Cell. Signal. pmid:18502612
Chen LY et al. Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18502815
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Rapizzi E et al. Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. 2008 Mol. Cell. Biochem. pmid:18454302
Son DJ et al. Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18571912
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Cheon S et al. Sphingosine kinase inhibitor suppresses IL-18-induced interferon-gamma production through inhibition of p38 MAPK activation in human NK cells. 2008 Biochem. Biophys. Res. Commun. pmid:18602364
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Kihara A and Igarashi Y Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720. 2008 Biochim. Biophys. Acta pmid:18555808
Kaya H et al. Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? 2008 Fertil. Steril. pmid:17517398
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Heller R et al. Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. 2008 Cardiovasc. Res. pmid:18558630
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Gude DR et al. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. 2008 FASEB J. pmid:18362204
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Stuebe S et al. Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. 2008 Naunyn Schmiedebergs Arch. Pharmacol. pmid:18046543
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Nussbaumer P et al. An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate. 2008 Chem. Phys. Lipids pmid:18039471
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Johann AM et al. Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. 2008 J. Immunol. pmid:18178864
Oskeritzian CA et al. Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. 2008 Blood pmid:18178871
Oyama O et al. The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. 2008 Cardiovasc. Res. pmid:18187460
Patschan S et al. Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18203850
Eskan MA et al. Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells. 2008 J. Immunol. pmid:18209079
Sekiguchi M et al. Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. 2008 J. Immunol. pmid:18209090
Brunati AM et al. Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. 2008 Biochim. Biophys. Acta pmid:18157950
Gingras D et al. Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells. 2008 FEBS Lett. pmid:18164686