Abuhusain HJ et al. |
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. |
2013 |
J. Biol. Chem. |
pmid:24265321
|
Bolli MH et al. |
Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes. |
2013 |
J. Med. Chem. |
pmid:24266709
|
Das A et al. |
The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. |
2013 |
Biomaterials |
pmid:24064148
|
Garris CS et al. |
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. |
2013 |
Nat. Immunol. |
pmid:24076635
|
Koch A et al. |
PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. |
2013 |
Biochim. Biophys. Acta |
pmid:23906789
|
Herzog BH et al. |
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. |
2013 |
Nature |
pmid:23995678
|
Kotani T et al. |
Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. |
2013 |
Biol. Reprod. |
pmid:23863409
|
Zhao CG et al. |
Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. |
2013 |
Physiol Res |
pmid:23869887
|
Knapp M et al. |
Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. |
2013 |
Prostaglandins Other Lipid Mediat. |
pmid:24120760
|
Yuan S et al. |
Lipid receptor S1Pâ‚ activation scheme concluded from microsecond all-atom molecular dynamics simulations. |
2013 |
PLoS Comput. Biol. |
pmid:24098103
|
Xiang SY et al. |
Lysophospholipid receptor activation of RhoA and lipid signaling pathways. |
2013 |
Biochim. Biophys. Acta |
pmid:22986288
|
Ota K et al. |
TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. |
2013 |
Endocrinology |
pmid:23861379
|
Harijith A et al. |
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. |
2013 |
Am. J. Pathol. |
pmid:23933064
|
Cortez-Retamozo V et al. |
Angiotensin II drives the production of tumor-promoting macrophages. |
2013 |
Immunity |
pmid:23333075
|
Ono Y et al. |
Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. |
2013 |
Lipids Health Dis |
pmid:23418753
|
Bot M et al. |
Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. |
2013 |
PLoS ONE |
pmid:23700419
|
Arce FT et al. |
Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. |
2013 |
Nanomedicine |
pmid:23523769
|
Herr DR et al. |
Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. |
2013 |
J. Biol. Chem. |
pmid:24003216
|
Dave JM et al. |
Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). |
2013 |
J. Biol. Chem. |
pmid:24005669
|
Deng H et al. |
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. |
2013 |
ACS Med Chem Lett |
pmid:24900589
|
GarcÃa-Bernal D et al. |
Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function. |
2013 |
J. Pathol. |
pmid:22711564
|
Southern C et al. |
Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. |
2013 |
J Biomol Screen |
pmid:23396314
|
Takuwa Y et al. |
Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases. |
2013 |
Biochim. Biophys. Acta |
pmid:22735357
|
Olivera A et al. |
Shaping the landscape: metabolic regulation of S1P gradients. |
2013 |
Biochim. Biophys. Acta |
pmid:22735358
|
Karliner JS |
Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. |
2013 |
Biochim. Biophys. Acta |
pmid:22735359
|
Wang X et al. |
Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. |
2013 |
Biochem. Pharmacol. |
pmid:24134913
|
Walls SM et al. |
Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. |
2013 |
PLoS Genet. |
pmid:24339790
|
Mierzejewska K et al. |
Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow. |
2013 |
Biomed Res Int |
pmid:24490172
|
Ley S et al. |
The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. |
2013 |
Oncogene |
pmid:22410777
|
Polzin A et al. |
Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction. |
2013 |
Int. J. Cardiol. |
pmid:24169533
|
Dziak R |
The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. |
2013 |
Immunol. Invest. |
pmid:24004055
|
Kunkel GT et al. |
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. |
2013 |
Nat Rev Drug Discov |
pmid:23954895
|
Gorshkova IA et al. |
Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. |
2013 |
Life Sci. |
pmid:23892195
|
Beckham TH et al. |
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. |
2013 |
PLoS ONE |
pmid:24098536
|
Xiong Y et al. |
Sphingosine kinases are not required for inflammatory responses in macrophages. |
2013 |
J. Biol. Chem. |
pmid:24081141
|
Zhang W et al. |
ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. |
2013 |
J. Biol. Chem. |
pmid:24064218
|
Babahosseini H et al. |
Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. |
2013 |
Integr Biol (Camb) |
pmid:24056950
|
Zhang O et al. |
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. |
2013 |
Mol. Microbiol. |
pmid:23980754
|
Olivera A et al. |
Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. |
2013 |
J. Leukoc. Biol. |
pmid:23904439
|
Sun X et al. |
Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. |
2013 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:23911438
|
Kusch A et al. |
Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. |
2013 |
Acta Physiol (Oxf) |
pmid:23432924
|
Loetscher E et al. |
Assay to measure the secretion of sphingosine-1-phosphate from cells induced by S1P lyase inhibitors. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23499842
|
Moriue T et al. |
Sphingosine 1-phosphate attenuates peroxide-induced apoptosis in HaCaT cells cultured in vitro. |
2013 |
Clin. Exp. Dermatol. |
pmid:23837937
|
Adada M et al. |
Sphingosine-1-phosphate receptor 2. |
2013 |
FEBS J. |
pmid:23879641
|
Gao X et al. |
Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. |
2013 |
Lipids |
pmid:23881382
|
Karimian G et al. |
Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis. |
2013 |
Biochim. Biophys. Acta |
pmid:23816565
|
Liu Y et al. |
Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. |
2013 |
J. Pathol. |
pmid:23839903
|
Riccitelli E et al. |
Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. |
2013 |
PLoS ONE |
pmid:23826381
|
Wang Y et al. |
Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. |
2013 |
Endocrinology |
pmid:23787120
|
Wang Z et al. |
Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. |
2013 |
Structure |
pmid:23602659
|
Salmanzadeh A et al. |
Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. |
2013 |
Integr Biol (Camb) |
pmid:23609351
|
Orr Gandy KA et al. |
Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. |
2013 |
FASEB J. |
pmid:23629860
|
Schneider G et al. |
Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. |
2013 |
Mol. Cancer Res. |
pmid:23615526
|
Cinq-Frais C et al. |
A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. |
2013 |
Biochim. Biophys. Acta |
pmid:23651497
|
Billich A et al. |
Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. |
2013 |
Anal. Biochem. |
pmid:23246729
|
Karapetyan AV et al. |
Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. |
2013 |
Stem Cells Dev. |
pmid:23282236
|
Kleinjan A et al. |
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. |
2013 |
Allergy |
pmid:23253209
|
Kager LM et al. |
Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis). |
2013 |
J. Thromb. Haemost. |
pmid:23216621
|
Liang J et al. |
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. |
2013 |
Cancer Cell |
pmid:23273921
|
Jiang LI et al. |
Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. |
2013 |
Mol. Pharmacol. |
pmid:23229509
|
Park K et al. |
A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. |
2013 |
Mol. Cell. Biol. |
pmid:23230267
|
CamprubÃ-Robles M et al. |
Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. |
2013 |
J. Neurosci. |
pmid:23392686
|
Yasuo M et al. |
Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. |
2013 |
PLoS ONE |
pmid:23326540
|
Kim YD et al. |
Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. |
2013 |
Mol. Cells |
pmid:23307289
|
Sharma N et al. |
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. |
2013 |
J. Leukoc. Biol. |
pmid:23345392
|
Salvemini D et al. |
Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. |
2013 |
Trends Pharmacol. Sci. |
pmid:23318139
|
Tibolla G et al. |
Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. |
2013 |
PLoS ONE |
pmid:23320105
|
Lee YJ et al. |
Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. |
2013 |
Int. J. Mol. Med. |
pmid:23381659
|
Yangyuoru PM et al. |
Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. |
2013 |
Methods Mol. Biol. |
pmid:23386355
|
Dillahunt SE et al. |
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. |
2013 |
J. Immunol. |
pmid:23359503
|
Tong X et al. |
High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. |
2013 |
Cardiovasc Diabetol |
pmid:23360427
|
Del Galdo S et al. |
The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. |
2013 |
Cell. Signal. |
pmid:23993968
|
Cartwright TA et al. |
Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. |
2013 |
J. Cereb. Blood Flow Metab. |
pmid:23168528
|
Carr JM et al. |
Sphingosine kinase 1 in viral infections. |
2013 |
Rev. Med. Virol. |
pmid:22639116
|
Véret J et al. |
Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival. |
2013 |
Biochim. Biophys. Acta |
pmid:23085009
|
Di Menna L et al. |
Fingolimod protects cultured cortical neurons against excitotoxic death. |
2013 |
Pharmacol. Res. |
pmid:23073075
|
Zu Heringdorf DM et al. |
Pharmacology of the sphingosine-1-phosphate signalling system. |
2013 |
Handb Exp Pharmacol |
pmid:23579459
|
Matheu MP et al. |
Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. |
2013 |
PLoS ONE |
pmid:23533579
|
Sobel K et al. |
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. |
2013 |
J. Biol. Chem. |
pmid:23589284
|
Kikuta J et al. |
Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23569273
|
Nguyen DH et al. |
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23569284
|
Alberg AJ et al. |
Plasma sphingolipids and lung cancer: a population-based, nested case-control study. |
2013 |
Cancer Epidemiol. Biomarkers Prev. |
pmid:23749868
|
Willis MA and Cohen JA |
Fingolimod therapy for multiple sclerosis. |
2013 |
Semin Neurol |
pmid:23709211
|
Tatematsu S et al. |
Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. |
2013 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:23723371
|
Guo L et al. |
Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. |
2013 |
Theriogenology |
pmid:23731666
|
Pyne NJ et al. |
Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. |
2013 |
Biochim. Biophys. Acta |
pmid:22801038
|
Zhang L et al. |
Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P). |
2013 |
Blood |
pmid:23775711
|
Park K et al. |
Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. |
2013 |
J. Invest. Dermatol. |
pmid:23856934
|
Koch A et al. |
Sphingosine 1-phosphate in renal diseases. |
2013 |
Cell. Physiol. Biochem. |
pmid:23736205
|
Lukowski ZL et al. |
Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. |
2013 |
J. Glaucoma |
pmid:21946553
|
Fukuhara S and Mochizuki N |
[Lymphocytes mobilization into blood regulated by Spns2, a sphingosine 1-phosphate transporter, expressed on endothelial cells]. |
2013 |
Seikagaku |
pmid:23717873
|
O'Sullivan C and Dev KK |
The structure and function of the S1P1 receptor. |
2013 |
Trends Pharmacol. Sci. |
pmid:23763867
|
Chang CH et al. |
Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. |
2013 |
Acta Pharmacol. Sin. |
pmid:23377549
|
Cuvillier O et al. |
Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. |
2013 |
Adv. Cancer Res. |
pmid:23290779
|
Alshaker H et al. |
Therapeutic potential of targeting SK1 in human cancers. |
2013 |
Adv. Cancer Res. |
pmid:23290780
|
Ohkuni A et al. |
Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:24269233
|
Heffernan-Stroud LA and Obeid LM |
Sphingosine kinase 1 in cancer. |
2013 |
Adv. Cancer Res. |
pmid:23290781
|
Zhang J et al. |
Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. |
2013 |
Hum. Reprod. |
pmid:24001716
|
Kihara A |
[Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. |
2013 |
Seikagaku |
pmid:23980469
|
Knapp M et al. |
Dose-dependent effect of aspirin on the level of sphingolipids in human blood. |
2013 |
Adv Med Sci |
pmid:24101372
|