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FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. |
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Biochem. Cell Biol. |
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Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. |
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High levels of sphingolipids in human breast cancer. |
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Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. |
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J Neuroinflammation |
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Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. |
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PLoS ONE |
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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. |
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FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. |
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Mol. Cancer Ther. |
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Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. |
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Cell Biol. Int. |
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Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. |
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Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. |
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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
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Clin. Chim. Acta |
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[Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. |
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Familial hypercholesterolaemia: cholesterol efflux and coronary disease. |
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
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Diabetes |
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Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. |
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PLoS ONE |
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Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. |
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Cell Chem Biol |
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Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. |
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Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. |
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ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. |
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Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. |
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Oncotarget |
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Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. |
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PLoS ONE |
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. |
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Mediators Inflamm. |
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Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. |
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Sci Rep |
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Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. |
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J Biomed Mater Res A |
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Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
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Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. |
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Annu. Rev. Physiol. |
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Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. |
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
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Mol. Biol. Cell |
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Acid ceramidase is upregulated in AML and represents a novel therapeutic target. |
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Oncotarget |
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
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Mol. Hum. Reprod. |
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An oncogenic role for sphingosine kinase 2. |
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Oncotarget |
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Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. |
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Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. |
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Acta Derm. Venereol. |
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Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
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Acta Biomater |
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Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival. |
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Cell. Signal. |
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Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. |
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
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Neurology |
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The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
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Nature |
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Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. |
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Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
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Am. J. Pathol. |
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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
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Neuropharmacology |
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Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
2017 |
PLoS ONE |
pmid:28125641
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Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
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Annu. Rev. Physiol. |
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Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
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Acta Haematol. |
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Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
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Biofactors |
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
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J. Lipid Res. |
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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
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Gastroenterology |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
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Cancer |
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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
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Chemosphere |
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Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
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Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. |
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Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. |
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SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. |
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Autophagy |
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Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. |
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J. Atheroscler. Thromb. |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
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Neuropharmacology |
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The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
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CNS Neurol Disord Drug Targets |
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High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
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Nature |
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The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
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Mol. Biol. Cell |
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Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
2017 |
BMC Genomics |
pmid:28851267
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A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
2017 |
Int J Mol Sci |
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Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
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Otol. Neurotol. |
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Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. |
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Int J Mol Sci |
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Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. |
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Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. |
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Thromb. Res. |
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Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
2017 |
Microb. Pathog. |
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DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. |
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Cell Commun. Signal |
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The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. |
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
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Adv Biol Regul |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
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Atherosclerosis |
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HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
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Epithelial cell extrusion: Pathways and pathologies. |
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Semin. Cell Dev. Biol. |
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
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PLoS ONE |
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
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PLoS ONE |
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Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
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PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
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Exp. Mol. Pathol. |
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
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J. Endocrinol. |
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Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
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Invest. Ophthalmol. Vis. Sci. |
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A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. |
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Arterioscler. Thromb. Vasc. Biol. |
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The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. |
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Tumour Biol. |
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Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes. |
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J. Cell. Physiol. |
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Ageing adversely affects the migration and function of marginal zone B cells. |
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Immunology |
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Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
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Biomed Res Int |
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Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
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Gastroenterology |
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Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
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Int J Mol Sci |
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Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
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Arterioscler. Thromb. Vasc. Biol. |
pmid:28360087
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Gusman DH and Shoemake C |
Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
2017 |
Yale J Biol Med |
pmid:28356890
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
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Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
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Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. |
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Arterioscler. Thromb. Vasc. Biol. |
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The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
2017 |
Hepatology |
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