De Luca T et al. |
NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. |
2005 |
Biofactors |
pmid:16873929
|
Stahelin RV et al. |
The mechanism of membrane targeting of human sphingosine kinase 1. |
2005 |
J. Biol. Chem. |
pmid:16243846
|
Perez GI et al. |
A central role for ceramide in the age-related acceleration of apoptosis in the female germline. |
2005 |
FASEB J. |
pmid:15728664
|
Lindner K et al. |
Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. |
2005 |
Br. J. Pharmacol. |
pmid:15735657
|
Ikeda M et al. |
Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15737611
|
Yabu T et al. |
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. |
2005 |
Blood |
pmid:15741222
|
Kee TH et al. |
Sphingosine kinase signalling in immune cells. |
2005 |
Clin. Exp. Pharmacol. Physiol. |
pmid:15743396
|
Suomalainen L et al. |
Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. |
2005 |
Am. J. Pathol. |
pmid:15743789
|
Pilorget A et al. |
Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. |
2005 |
J. Cereb. Blood Flow Metab. |
pmid:15829917
|
Bolick DT et al. |
Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. |
2005 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15761190
|
Blom T et al. |
Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. |
2005 |
Cell. Signal. |
pmid:15763425
|
Im YJ et al. |
Study on action mode of sphingosine 1-phosphate in rat hepatocytes. |
2005 |
J. Pharmacol. Sci. |
pmid:15764837
|
Oberst MD et al. |
HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. |
2005 |
Am. J. Physiol., Cell Physiol. |
pmid:15800053
|
Cyster JG |
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. |
2005 |
Annu. Rev. Immunol. |
pmid:15771568
|
Church LD et al. |
TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx. |
2005 |
J. Leukoc. Biol. |
pmid:15817701
|
Tamama K et al. |
High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. |
2005 |
Atherosclerosis |
pmid:15585196
|
Zhang B et al. |
Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. |
2005 |
Atherosclerosis |
pmid:15585219
|
Kihara A et al. |
[Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. |
2005 |
Tanpakushitsu Kakusan Koso |
pmid:16146193
|
Fieger CB et al. |
Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. |
2005 |
FASEB J. |
pmid:16148028
|
Donati C et al. |
Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. |
2005 |
FASEB J. |
pmid:15625079
|
Damirin A et al. |
Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells. |
2005 |
Mol. Pharmacol. |
pmid:15625281
|
Vessey DA et al. |
A rapid radioassay for sphingosine kinase. |
2005 |
Anal. Biochem. |
pmid:15649386
|
Foss FW et al. |
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:16125386
|
van Meeteren LA et al. |
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. |
2005 |
J. Biol. Chem. |
pmid:15769751
|
Tani M et al. |
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. |
2005 |
J. Biol. Chem. |
pmid:16126722
|
Huang WR et al. |
[Effects of sphingosine 1-phosphate on functions of T cell - review]. |
2005 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:16129068
|
Saini HS et al. |
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. |
2005 |
J. Neurochem. |
pmid:16313513
|
Mizugishi K et al. |
Essential role for sphingosine kinases in neural and vascular development. |
2005 |
Mol. Cell. Biol. |
pmid:16314531
|
Shida D et al. |
Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15649431
|
Lee HS et al. |
Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. |
2005 |
Cell Calcium |
pmid:16219349
|
Chalfant CE and Spiegel S |
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. |
2005 |
J. Cell. Sci. |
pmid:16219683
|
Armulik A et al. |
Endothelial/pericyte interactions. |
2005 |
Circ. Res. |
pmid:16166562
|
Pchejetski D et al. |
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. |
2005 |
Cancer Res. |
pmid:16357178
|
Itagaki K et al. |
Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. |
2005 |
J. Leukoc. Biol. |
pmid:15522918
|
McVerry BJ and Garcia JG |
In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. |
2005 |
Cell. Signal. |
pmid:15494205
|
Waters CM et al. |
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. |
2005 |
Cell. Signal. |
pmid:15494217
|
Butter JJ et al. |
A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. |
2005 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:16023899
|
Maguire JJ and Davenport AP |
Regulation of vascular reactivity by established and emerging GPCRs. |
2005 |
Trends Pharmacol. Sci. |
pmid:16054240
|
Yopp AC et al. |
Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. |
2005 |
J. Immunol. |
pmid:16116177
|
Czeloth N et al. |
Sphingosine-1-phosphate mediates migration of mature dendritic cells. |
2005 |
J. Immunol. |
pmid:16116182
|
Bandhuvula P et al. |
The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. |
2005 |
J. Biol. Chem. |
pmid:16118221
|
Tanski WJ et al. |
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. |
2005 |
J. Vasc. Surg. |
pmid:15696050
|
Björklund S et al. |
Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. |
2005 |
Mol. Cell. Endocrinol. |
pmid:15713536
|
Anelli V et al. |
Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. |
2005 |
J. Neurochem. |
pmid:15715670
|
Mehta D et al. |
Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. |
2005 |
J. Biol. Chem. |
pmid:15728185
|
Formigli L et al. |
Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels. |
2005 |
J. Cell. Sci. |
pmid:15728255
|
Minnear FL et al. |
Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. |
2005 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15778280
|
Inagaki Y et al. |
Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. |
2005 |
Biochem. J. |
pmid:15733055
|
Ohmori T et al. |
The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. |
2005 |
Thromb. Res. |
pmid:15733975
|
Hsiao SH et al. |
Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. |
2005 |
Toxicol. Sci. |
pmid:15829618
|
Murakami T et al. |
Synthesis and biological properties of novel sphingosine derivatives. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:15686924
|
Edsbagge J et al. |
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. |
2005 |
Development |
pmid:15689381
|
Jaillard C et al. |
Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. |
2005 |
J. Neurosci. |
pmid:15703400
|
Geoffroy K et al. |
Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. |
2005 |
FEBS Lett. |
pmid:15710421
|
Budnik LT and Brunswig-Spickenheier B |
Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. |
2005 |
J. Lipid Res. |
pmid:15716590
|
Duan HF et al. |
[Establishment of a method for determining the sphingosine kinase activity and its initial application]. |
2005 |
Zhongguo Ying Yong Sheng Li Xue Za Zhi |
pmid:21180179
|
Takashiro Y et al. |
Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. |
2005 |
Biochem. Pharmacol. |
pmid:15907808
|
Halin C et al. |
The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. |
2005 |
Blood |
pmid:15870184
|
Takeshita A et al. |
Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. |
2005 |
J Oral Sci |
pmid:15881228
|
Yin Z and Watsky MA |
Chloride channel activity in human lung fibroblasts and myofibroblasts. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:15681397
|
Sauer B et al. |
Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. |
2005 |
Pharmazie |
pmid:15881612
|
Ma Y et al. |
Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. |
2005 |
J. Biol. Chem. |
pmid:15883165
|
Radeke HH et al. |
Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. |
2005 |
J. Immunol. |
pmid:15728487
|
Kim JW et al. |
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. |
2005 |
Bioorg. Med. Chem. |
pmid:15848761
|
Kawata T et al. |
Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15850807
|
Pfaff M et al. |
Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. |
2005 |
Respir. Res. |
pmid:15927078
|
Petrache I et al. |
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. |
2005 |
Nat. Med. |
pmid:15852018
|
Mastrandrea LD et al. |
Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. |
2005 |
Diabetes |
pmid:15855330
|
Segura BJ et al. |
Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. |
2005 |
Brain Res. Mol. Brain Res. |
pmid:15710251
|
Kim KS et al. |
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. |
2005 |
FASEB J. |
pmid:15857892
|
Pettus BJ et al. |
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. |
2005 |
Mol. Pharmacol. |
pmid:15900018
|
Katsuma S et al. |
Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. |
2005 |
FEBS Lett. |
pmid:15862293
|
Ledent C et al. |
Premature ovarian aging in mice deficient for Gpr3. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:15956199
|
Wu WT et al. |
Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. |
2005 |
Endocrinology |
pmid:15878967
|
Kariya Y et al. |
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. |
2005 |
Genes Cells |
pmid:15938718
|
Abbey-Hosch SE et al. |
Differential regulation of NPR-B/GC-B by protein kinase c and calcium. |
2005 |
Biochem. Pharmacol. |
pmid:16005434
|
Osawa Y et al. |
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. |
2005 |
J. Biol. Chem. |
pmid:15946935
|
Clemens JJ et al. |
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:15982878
|
Zaslavsky A et al. |
Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. |
2005 |
FEBS Lett. |
pmid:15987639
|
Chae SS and Hla T |
Inhibition of gene expression in vivo using multiplex siRNA. |
2005 |
Methods Mol. Biol. |
pmid:15990401
|
Berdyshev EV et al. |
Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. |
2005 |
Anal. Biochem. |
pmid:15766719
|
Pébay A et al. |
Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. |
2005 Nov-Dec |
Stem Cells |
pmid:16081668
|
Seol GH et al. |
Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells. |
2005 Sep-Dec |
Endothelium |
pmid:16410226
|
Ryu J et al. |
Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. |
2006 |
EMBO J. |
pmid:17124500
|
Jin YX et al. |
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. |
2006 |
Arch. Pharm. Res. |
pmid:17146975
|
Taha TA et al. |
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. |
2006 |
Biochim. Biophys. Acta |
pmid:17161984
|
Milstien S and Spiegel S |
Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. |
2006 |
Cancer Cell |
pmid:16530698
|
Visentin B et al. |
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. |
2006 |
Cancer Cell |
pmid:16530706
|
Scherer EQ et al. |
Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies? |
2006 |
Cardiovasc. Res. |
pmid:16533504
|
Rouach N et al. |
S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. |
2006 |
Eur. J. Neurosci. |
pmid:16553609
|
Brizuela L et al. |
Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. |
2006 |
J. Lipid Res. |
pmid:16554657
|
Chatterjee S et al. |
The role of the phospholipid sphingomyelin in heart disease. |
2006 |
Curr Opin Investig Drugs |
pmid:16555682
|
Yamashita H et al. |
Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. |
2006 |
J. Surg. Res. |
pmid:16183075
|
Sparkman L et al. |
Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. |
2006 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:16183668
|
Kim MY et al. |
Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells. |
2006 |
Am. J. Physiol., Cell Physiol. |
pmid:16267108
|
Nagata Y et al. |
Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. |
2006 |
J. Cell Biol. |
pmid:16847102
|
Xu R et al. |
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. |
2006 |
FASEB J. |
pmid:16940153
|
Schultz C |
Lipid-induced phenotypes. |
2006 |
Nat. Chem. Biol. |
pmid:16850012
|
Brinkmann V and Baumruker T |
Pulmonary and vascular pharmacology of sphingosine 1-phosphate. |
2006 |
Curr Opin Pharmacol |
pmid:16563863
|
Hemmings DG |
Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. |
2006 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:16570136
|