Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Miura Y et al. | Independence of tumor necrosis factor-alpha-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells. | 2004 | J. Thromb. Haemost. | pmid:15140149 |
Panetti TS et al. | Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid. | 2004 | J. Thromb. Haemost. | pmid:15333043 |
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Ren S et al. | Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. | 2009 | Kidney Int. | pmid:19657322 |
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Ratajczak MZ et al. | Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. | 2010 | Leukemia | pmid:20357827 |
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Nodai A et al. | Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. | 2007 | Life Sci. | pmid:17382352 |
Yu Y et al. | Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. | 2014 | Lipids | pmid:24158769 |
Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |
Chawla S and Saxena S | Differential modulation of S1PR(1-5) and specific activities of SphK and nSMase in pulmonary and cerebral tissues of rats exposed to hypobaric hypoxia. | 2015 | Lipids | pmid:25398597 |
Knapp M et al. | Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | 2012 | Lipids | pmid:22833182 |
Gao X et al. | Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. | 2013 | Lipids | pmid:23881382 |
Chawla S et al. | Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. | 2014 | Lipids | pmid:24190514 |
Ono Y et al. | Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. | 2013 | Lipids Health Dis | pmid:23418753 |
Wang F and Ye P | Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. | 2014 | Lipids Health Dis | pmid:25339382 |
Iino J et al. | Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. | 2014 | Lipids Health Dis | pmid:25253303 |
Abu El-Asrar AM et al. | Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. | 2014 | Lipids Health Dis | pmid:25496321 |
Argraves KM et al. | S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | 2011 | Lipids Health Dis | pmid:21554699 |
Ruiz M et al. | HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. | 2017 | Lipids Health Dis | pmid:28179022 |
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Aoyagi T et al. | The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. | 2012 | Lymphat Res Biol | pmid:22984905 |
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Syed SN et al. | S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. | 2017 | Mediators Inflamm. | pmid:28804221 |
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Obinata H and Hla T | Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. | 2012 | Methods Mol. Biol. | pmid:22528440 |
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