Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rivera R and Chun J | Biological effects of lysophospholipids. | 2008 | Rev. Physiol. Biochem. Pharmacol. | pmid:18481029 |
Kikuta J et al. | S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. | 2011 | Rheumatol. Int. | pmid:21113810 |
Chapurlat RD and Confavreux CB | Novel biological markers of bone: from bone metabolism to bone physiology. | 2016 | Rheumatology (Oxford) | pmid:26790456 |
Yatomi Y | [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. | 2006 | Rinsho Byori | pmid:16913663 |
Ohkawa R et al. | [Sphingolipids, possible biomarkers for atherosclerotic disorders]. | 2013 | Rinsho Byori | pmid:24369591 |
Kimura T et al. | [Measurement of sphingosine 1-phosphate as a biomarker of atherosclerosis]. | 2007 | Rinsho Byori | pmid:17511266 |
Fujii S | [Atherosclerosis, Chronic Inflammation, and Thrombosis: In Search of the Missing Link in Laboratory Medicine]. | 2015 | Rinsho Byori | pmid:26524900 |
Martino A et al. | Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells. | 2007 | Scand. J. Immunol. | pmid:17212771 |
Xie Z et al. | Targeting sphingosine-1-phosphate signaling for cancer therapy. | 2017 | Sci China Life Sci | pmid:28623546 |
Ma Y et al. | Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (Hâ‚‚Oâ‚‚) levels in guard cells in Vicia faba. | 2012 | Sci China Life Sci | pmid:23090064 |
Trinh HK et al. | Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. | 2016 | Sci Rep | pmid:27830727 |
Zhang H et al. | Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. | 2016 | Sci Rep | pmid:27476912 |
Jin J et al. | Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. | 2016 | Sci Rep | pmid:26948042 |
Ko P et al. | Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. | 2016 | Sci Rep | pmid:26877098 |
Wiltshire R et al. | Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. | 2016 | Sci Rep | pmid:26813587 |
Sheridan GK and Dev KK | Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. | 2014 | Sci Rep | pmid:24851861 |
Moruno Manchon JF et al. | Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy. | 2015 | Sci Rep | pmid:26477494 |
Patmanathan SN et al. | Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. | 2016 | Sci Rep | pmid:27160553 |
Yang L et al. | Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice. | 2015 | Sci Rep | pmid:26324256 |
Checa A et al. | Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment. | 2015 | Sci Rep | pmid:26174087 |
Riccio A | New endogenous regulators of class I histone deacetylases. | 2010 | Sci Signal | pmid:20051592 |
Eichner A and Sixt M | Setting the clock for recirculating lymphocytes. | 2011 | Sci Signal | pmid:22067458 |
Jung M et al. | Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. | 2016 | Sci Signal | pmid:27353364 |
Rodvold JJ and Zanetti M | Tumor microenvironment on the move and the Aselli connection. | 2016 | Sci Signal | pmid:27353363 |
Swendeman SL et al. | An engineered S1P chaperone attenuates hypertension and ischemic injury. | 2017 | Sci Signal | pmid:28811382 |
Cai Y et al. | FOXF1 maintains endothelial barrier function and prevents edema after lung injury. | 2016 | Sci Signal | pmid:27095594 |
Xiang SY et al. | PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. | 2013 | Sci Signal | pmid:24345679 |
Parrill AL et al. | Structure of the first sphingosine 1-phosphate receptor. | 2012 | Sci Signal | pmid:22623751 |
Galvani S et al. | HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. | 2015 | Sci Signal | pmid:26268607 |
Andrieu G et al. | Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. | 2017 | Sci Signal | pmid:28351953 |
Panneer Selvam S et al. | Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. | 2015 | Sci Signal | pmid:26082434 |
Sullards MC and Merrill AH | Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. | 2001 | Sci. STKE | pmid:11752637 |
Chun J | Immunology. The sources of a lipid conundrum. | 2007 | Science | pmid:17431159 |
Hait NC et al. | Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. | 2009 | Science | pmid:19729656 |
Kawahara A et al. | The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. | 2009 | Science | pmid:19074308 |
Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
Schwab SR et al. | Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | 2005 | Science | pmid:16151014 |
Hla T et al. | Lysophospholipids--receptor revelations. | 2001 | Science | pmid:11729304 |
Huang Y et al. | S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. | 2018 | Science | pmid:29302015 |
Mandala S et al. | Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. | 2002 | Science | pmid:11923495 |
Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
Pappu R et al. | Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. | 2007 | Science | pmid:17363629 |
Lee MJ et al. | Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. | 1998 | Science | pmid:9488656 |
Hla T and Im DS | Cell biology. The ABCs of lipophile transport. | 2009 | Science | pmid:19213902 |
Thathiah A et al. | The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. | 2009 | Science | pmid:19213921 |
Arnon TI et al. | GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. | 2011 | Science | pmid:21960637 |
Young N and Van Brocklyn JR | Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. | 2006 | ScientificWorldJournal | pmid:16906327 |
Tilly JL | Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. | 2001 | ScientificWorldJournal | pmid:12805661 |
Kihara A | [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics]. | 2006 | Seikagaku | pmid:16986722 |
Fukushima N | [A family of lysophospholipid receptors]. | 2000 | Seikagaku | pmid:11076202 |