Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Berdyshev EV et al. | De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | 2006 | Cell. Signal. | pmid:16529909 |
Milstien S and Spiegel S | Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. | 2006 | Cancer Cell | pmid:16530698 |
Visentin B et al. | Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. | 2006 | Cancer Cell | pmid:16530706 |
Scherer EQ et al. | Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies? | 2006 | Cardiovasc. Res. | pmid:16533504 |
Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? | 2006 | Cardiovasc. Res. | pmid:16542647 |
Ochi R et al. | Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. | 2006 | Cardiovasc. Res. | pmid:16545787 |
Rouach N et al. | S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. | 2006 | Eur. J. Neurosci. | pmid:16553609 |
Brizuela L et al. | Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. | 2006 | J. Lipid Res. | pmid:16554657 |
Chatterjee S et al. | The role of the phospholipid sphingomyelin in heart disease. | 2006 | Curr Opin Investig Drugs | pmid:16555682 |
Brinkmann V and Baumruker T | Pulmonary and vascular pharmacology of sphingosine 1-phosphate. | 2006 | Curr Opin Pharmacol | pmid:16563863 |
Hemmings DG | Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16570136 |
Hu W et al. | Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16574065 |
Zhi L et al. | Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. | 2006 | J. Cell. Physiol. | pmid:16575915 |
Taha TA et al. | Sphingosine kinase: biochemical and cellular regulation and role in disease. | 2006 | J. Biochem. Mol. Biol. | pmid:16584625 |
Wacker BK et al. | Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. | 2006 | Biomacromolecules | pmid:16602758 |
Wong RC et al. | Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16616002 |
Pan CY et al. | Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. | 2006 | Neuropharmacology | pmid:16616768 |
Yan L et al. | 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16621543 |
Venkataraman K et al. | Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. | 2006 | Biochem. J. | pmid:16623665 |
Malaplate-Armand C et al. | Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. | 2006 | Neurobiol. Dis. | pmid:16626961 |
Hiraga Y et al. | Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16631609 |
French KJ et al. | Antitumor activity of sphingosine kinase inhibitors. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16632640 |
Ahmad M et al. | The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647641 |
Kim MK et al. | Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16674917 |
Xu SZ et al. | A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. | 2006 | Circ. Res. | pmid:16675717 |
Jiang X and Han X | Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | 2006 | J. Lipid Res. | pmid:16682747 |
Weigert A et al. | Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. | 2006 | Blood | pmid:16690965 |
Eigenbrod S et al. | Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. | 2006 | Immunol. Invest. | pmid:16698674 |
Zhang YH et al. | Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons. | 2006 | J. Neurophysiol. | pmid:16723416 |
Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
Oz-Arslan D et al. | IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. | 2006 | J. Leukoc. Biol. | pmid:16769764 |
Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
Veracini L et al. | Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. | 2006 | J. Cell. Sci. | pmid:16787943 |
Laychock SG et al. | Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. | 2006 | Endocrinology | pmid:16794003 |
Lin CI et al. | Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. | 2006 | J. Cell. Biochem. | pmid:16795034 |
Zeidan YH et al. | Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. | 2006 | J. Biol. Chem. | pmid:16803890 |
Garbers DL et al. | Membrane guanylyl cyclase receptors: an update. | 2006 | Trends Endocrinol. Metab. | pmid:16815030 |
Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
von Wenckstern H et al. | The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. | 2006 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:16830220 |
Thompson B et al. | Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846783 |
Long JS et al. | The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846788 |
Nagata Y et al. | Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. | 2006 | J. Cell Biol. | pmid:16847102 |
Schultz C | Lipid-induced phenotypes. | 2006 | Nat. Chem. Biol. | pmid:16850012 |
Morales A et al. | Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo. | 2007 | Oncogene | pmid:16862171 |
De Luca T et al. | NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. | 2005 | Biofactors | pmid:16873929 |
Dragusin M et al. | Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. | 2006 | FASEB J. | pmid:16877527 |
Bjursell M et al. | G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16887097 |
Donati C and Bruni P | Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. | 2006 | Biochim. Biophys. Acta | pmid:16890187 |
Lee JF et al. | Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. | 2006 | J. Biol. Chem. | pmid:16891661 |
Natarajan J et al. | Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line. | 2006 | BMC Bioinformatics | pmid:16901352 |
Young N and Van Brocklyn JR | Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. | 2006 | ScientificWorldJournal | pmid:16906327 |
Yatomi Y | [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. | 2006 | Rinsho Byori | pmid:16913663 |
Leclercq TM and Pitson SM | Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. | 2006 | IUBMB Life | pmid:16916784 |
El-Shewy HM et al. | Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. | 2006 | J. Biol. Chem. | pmid:16926156 |
Huang WR et al. | [Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors]. | 2006 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16928321 |
Meriane M et al. | Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. | 2006 | Stem Cells | pmid:16931773 |
Xu R et al. | Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. | 2006 | FASEB J. | pmid:16940153 |
Igarashi J et al. | Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16943246 |
Smicun Y et al. | S1P regulation of ovarian carcinoma invasiveness. | 2006 | Gynecol. Oncol. | pmid:16956652 |
Leiber D et al. | Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16956968 |
Squecco R et al. | Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. | 2006 | Mol. Biol. Cell | pmid:16957055 |
Whetzel AM et al. | Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | 2006 | Circ. Res. | pmid:16960101 |
Tani M et al. | Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. | 2007 | Cell. Signal. | pmid:16963225 |
Massberg S and von Andrian UH | Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. | 2006 | N. Engl. J. Med. | pmid:16971715 |
Jun DJ et al. | Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. | 2006 | Endocrinology | pmid:16973728 |
Kohno M et al. | Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. | 2006 | Mol. Cell. Biol. | pmid:16980623 |
Theilmeier G et al. | High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. | 2006 | Circulation | pmid:16982942 |
Kihara A | [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics]. | 2006 | Seikagaku | pmid:16986722 |
Birgbauer E and Chun J | New developments in the biological functions of lysophospholipids. | 2006 | Cell. Mol. Life Sci. | pmid:16988788 |
Kimura A et al. | Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. | 2007 | Stem Cells | pmid:16990586 |
Hait NC et al. | Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. | 2006 | Biochim. Biophys. Acta | pmid:16996023 |
Hinson JS et al. | Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16997888 |
Minshall RD and Malik AB | Transport across the endothelium: regulation of endothelial permeability. | 2006 | Handb Exp Pharmacol | pmid:16999218 |
Ramasamy R et al. | Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. | 2006 | Circ. Res. | pmid:17008596 |
Dahm F et al. | Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | 2006 | J. Thromb. Haemost. | pmid:17010150 |
Rieken S et al. | Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11). | 2006 | J. Biol. Chem. | pmid:17023430 |
Sabbadini RA | Targeting sphingosine-1-phosphate for cancer therapy. | 2006 | Br. J. Cancer | pmid:17024123 |
Lavieu G et al. | Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? | 2007 Jan-Feb | Autophagy | pmid:17035732 |
Garg SK et al. | Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? | 2006 | Clin. Immunol. | pmid:17049310 |
Mitra P et al. | Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17050692 |
Zheng DM et al. | Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide. | 2006 | Hepatology | pmid:17058266 |
Hanessian S et al. | Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17070046 |
Idzko M et al. | Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. | 2006 | J. Clin. Invest. | pmid:17080194 |
Hancke K et al. | Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. | 2007 | Fertil. Steril. | pmid:17081530 |
Schmidt H et al. | LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085324 |
Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
Ki SH et al. | Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | 2007 | J. Biol. Chem. | pmid:17098744 |
Kabashima K et al. | Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. | 2006 | J. Exp. Med. | pmid:17101733 |
Kume H et al. | Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17105828 |
Mechtcheriakova D et al. | Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. | 2007 | Cell. Signal. | pmid:17113265 |
Pan S et al. | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. | 2006 | Chem. Biol. | pmid:17114004 |
Fujiwara Y et al. | Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. | 2007 | J. Biol. Chem. | pmid:17114791 |
Matsuo Y et al. | Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation. | 2007 | Atherosclerosis | pmid:17118370 |
Liao JJ et al. | Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. | 2007 | J. Biol. Chem. | pmid:17121832 |
Murph M et al. | Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. | 2006 | Clin. Cancer Res. | pmid:17121877 |
Ryu J et al. | Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. | 2006 | EMBO J. | pmid:17124500 |
Brahmbhatt VV et al. | Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. | 2007 | Chem. Phys. Lipids | pmid:17126823 |
Tan SY et al. | Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines. | 2007 | Front. Biosci. | pmid:17127411 |