Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jin YX et al. | Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. | 2006 | Arch. Pharm. Res. | pmid:17146975 |
Giussani P et al. | Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. | 2007 | Neurochem. Res. | pmid:17151916 |
Fisher KE et al. | Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. | 2006 | Mol. Cancer | pmid:17156449 |
Pchejetski D et al. | Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. | 2007 | Circ. Res. | pmid:17158340 |
Keul P et al. | The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17158351 |
Walter DH et al. | Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17158356 |
Jang S et al. | Cytochemical alterations in the rat retina by LPS administration. | 2007 | Neurochem. Res. | pmid:17160463 |
Taha TA et al. | A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. | 2006 | Biochim. Biophys. Acta | pmid:17161984 |
Jeng YJ et al. | Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17164439 |
Harvey KA et al. | Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation. | 2007 | J. Cell. Physiol. | pmid:17167780 |
Huwiler A and Pfeilschifter J | Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. | 2006 | Curr. Pharm. Des. | pmid:17168766 |
Deng Q et al. | Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies. | 2007 | Mol. Pharmacol. | pmid:17170199 |
Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
Soares R and Azevedo I | Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? | 2007 | Free Radic. Biol. Med. | pmid:17189836 |
Barthomeuf C | Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols. | 2007 | Free Radic. Biol. Med. | pmid:17189837 |
Maceyka M et al. | Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. | 2007 | Circ. Res. | pmid:17204658 |
Guo Y et al. | Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | 2007 | Mol. Cell Proteomics | pmid:17210631 |
Martino A et al. | Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells. | 2007 | Scand. J. Immunol. | pmid:17212771 |
Hänel P et al. | Erythrocytes store and release sphingosine 1-phosphate in blood. | 2007 | FASEB J. | pmid:17215483 |
Gonzalez-Cabrera PJ et al. | Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. | 2007 | J. Biol. Chem. | pmid:17218309 |
Igarashi J et al. | Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | 2007 | Br. J. Pharmacol. | pmid:17220911 |
Currie JC et al. | MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. | 2007 | J. Biol. Chem. | pmid:17229722 |
Beech DJ | Bipolar phospholipid sensing by TRPC5 calcium channel. | 2007 | Biochem. Soc. Trans. | pmid:17233612 |
Kunisawa J et al. | Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. | 2007 | Blood | pmid:17234743 |
Nofer JR et al. | FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. | 2007 | Circulation | pmid:17242282 |
Alemany R et al. | Regulation and functional roles of sphingosine kinases. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17242884 |
Inniss K and Moore H | Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate. | 2006 | Stem Cells Dev. | pmid:17253942 |
Novgorodov AS et al. | Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. | 2007 | FASEB J. | pmid:17255471 |
Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
Baranowski M et al. | Pioglitazone induces de novo ceramide synthesis in the rat heart. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259076 |
Herr DR and Chun J | Effects of LPA and S1P on the nervous system and implications for their involvement in disease. | 2007 | Curr Drug Targets | pmid:17266539 |
Rosen H et al. | Tipping the gatekeeper: S1P regulation of endothelial barrier function. | 2007 | Trends Immunol. | pmid:17276731 |
Peters SL and Alewijnse AE | Sphingosine-1-phosphate signaling in the cardiovascular system. | 2007 | Curr Opin Pharmacol | pmid:17280869 |
Tellier E et al. | Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. | 2007 | Mol. Cell. Biol. | pmid:17283058 |
Jiang LI et al. | Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. | 2007 | J. Biol. Chem. | pmid:17283075 |
Kono M et al. | Deafness and stria vascularis defects in S1P2 receptor-null mice. | 2007 | J. Biol. Chem. | pmid:17284444 |
Herr DR et al. | Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. | 2007 | J. Neurosci. | pmid:17287522 |
Means CK et al. | Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17293497 |
Formigli L et al. | Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts. | 2007 | J. Cell. Physiol. | pmid:17295211 |
Baumruker T et al. | FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. | 2007 | Expert Opin Investig Drugs | pmid:17302523 |
Baran Y et al. | Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. | 2007 | J. Biol. Chem. | pmid:17303574 |
Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
Koh E et al. | Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation. | 2007 | Cell. Signal. | pmid:17307336 |
Jung ID et al. | Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. | 2007 | Int. Immunol. | pmid:17307797 |
Bonnaud S et al. | Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. | 2007 | Cancer Res. | pmid:17308123 |
Pilorget A et al. | Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. | 2007 | J. Neurochem. | pmid:17316399 |
Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
Roviezzo F et al. | Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322125 |
Kajimoto T et al. | Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. | 2007 | Mol. Cell. Biol. | pmid:17325039 |
Nombela-Arrieta C et al. | A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. | 2007 | J. Exp. Med. | pmid:17325199 |
Lin CI et al. | Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17331465 |
Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. | 2007 | Cardiovasc. Res. | pmid:17331485 |
Landeen LK et al. | Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17337593 |
Maeda Y et al. | Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. | 2007 | J. Immunol. | pmid:17339438 |
Serriere-Lanneau V et al. | The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. | 2007 | FASEB J. | pmid:17341687 |
Olivera A et al. | The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. | 2007 | Immunity | pmid:17346996 |
Catarzi S et al. | Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase. | 2007 | Biochim. Biophys. Acta | pmid:17349748 |
Park KS et al. | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17349972 |
Xue X et al. | Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17360805 |
Oskouian B and Saba J | Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. | 2007 | Cell Cycle | pmid:17361098 |
Pappu R et al. | Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. | 2007 | Science | pmid:17363629 |
Torkhovskaya TI et al. | Lysophospholipid receptors in cell signaling. | 2007 | Biochemistry Mosc. | pmid:17367289 |
Masuko K et al. | Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes. | 2007 | BMC Musculoskelet Disord | pmid:17374154 |
Young N and Van Brocklyn JR | Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness. | 2007 | Exp. Cell Res. | pmid:17376432 |
Nakamura T et al. | Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. | 2007 | Bioorg. Med. Chem. | pmid:17379528 |
Zhao Y et al. | Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. | 2007 | J. Biol. Chem. | pmid:17379599 |
Nodai A et al. | Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. | 2007 | Life Sci. | pmid:17382352 |
Nyalendo C et al. | Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration. | 2007 | J. Biol. Chem. | pmid:17389600 |
Okazaki M et al. | Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation. | 2007 | Am. J. Transplant. | pmid:17391120 |
Milstien S et al. | Sphingosine 1-phosphate in neural signalling and function. | 2007 | Acta Paediatr Suppl | pmid:17391440 |
Michel MC et al. | Vascular effects of sphingolipids. | 2007 | Acta Paediatr Suppl | pmid:17391441 |
Goetzl EJ et al. | Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. | 2007 | Acta Paediatr Suppl | pmid:17391442 |
Aoki S et al. | The suppressive effect of sphingosine 1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins alpha(5)beta(1) and alpha(v)beta(3). | 2007 | J. Thromb. Haemost. | pmid:17403093 |
Hudson NK et al. | Modulation of human arterial tone during pregnancy: the effect of the bioactive metabolite sphingosine-1-phosphate. | 2007 | Biol. Reprod. | pmid:17409372 |
Ito K et al. | Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17418101 |
Xia P | Letter by Xia regarding article, "High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor". | 2007 | Circulation | pmid:17420358 |
Jacobson JR and Garcia JG | Novel therapies for microvascular permeability in sepsis. | 2007 | Curr Drug Targets | pmid:17430121 |
Chun J | Immunology. The sources of a lipid conundrum. | 2007 | Science | pmid:17431159 |
Sanchez T et al. | Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17431187 |
Baranowski M et al. | PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | 2007 | J. Physiol. Pharmacol. | pmid:17440226 |
Liao JJ et al. | Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17442922 |
Kihara A et al. | Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. | 2007 | Prog. Lipid Res. | pmid:17449104 |
Watterson KR et al. | Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. | 2007 | FASEB J. | pmid:17449719 |
Shin JH et al. | Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. | 2007 | J. Korean Med. Sci. | pmid:17449940 |
Donati C et al. | Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. | 2007 | Stem Cells | pmid:17464089 |
Naor MM et al. | Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences. | 2007 | J. Mol. Graph. Model. | pmid:17467317 |
Togame H et al. | Development of a simple and robust assay to screen for inhibitors of sphingosine kinases. | 2007 | Assay Drug Dev Technol | pmid:17477830 |
Choi CH et al. | Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. | 2007 | Arch. Pharm. Res. | pmid:17489368 |
Jongsma M et al. | Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17497135 |
Zabielski P et al. | Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17499747 |
Kimura T et al. | [Measurement of sphingosine 1-phosphate as a biomarker of atherosclerosis]. | 2007 | Rinsho Byori | pmid:17511266 |
Aoki S et al. | Fluid shear stress enhances the sphingosine 1-phosphate responses in cell-cell interactions between platelets and endothelial cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17512899 |
Huang MC et al. | Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. | 2007 | J. Immunol. | pmid:17513728 |
Kaya H et al. | Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? | 2008 | Fertil. Steril. | pmid:17517398 |
Levine YC et al. | Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. | 2007 | J. Biol. Chem. | pmid:17519230 |
Langlois S et al. | Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation. | 2007 | Mol. Cancer Res. | pmid:17541067 |
Sato K et al. | HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17544365 |
Anada Y et al. | The immunomodulator FTY720 is phosphorylated and released from platelets. | 2007 | Eur. J. Pharmacol. | pmid:17553484 |
Gandolfo MT and Rabb H | Very early alloantigen-independent trafficking of lymphocytes during ischemic acute kidney injury. | 2007 | Kidney Int. | pmid:17554348 |
Keul P et al. | HDL and its sphingosine-1-phosphate content in cardioprotection. | 2007 | Heart Fail Rev | pmid:17554629 |