Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Niemann-Pick Disease, Type C D052556 1 associated lipids
Farber Lipogranulomatosis D055577 1 associated lipids
Tachycardia, Sinus D013616 2 associated lipids
Sensation Disorders D012678 2 associated lipids
Ileus D045823 3 associated lipids
Fabry Disease D000795 4 associated lipids
Hematologic Neoplasms D019337 4 associated lipids
Shock, Hemorrhagic D012771 4 associated lipids
Adenomatous Polyps D018256 4 associated lipids
Pregnancy, Ectopic D011271 5 associated lipids
Ovarian Diseases D010049 5 associated lipids
Dilatation, Pathologic D004108 5 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Teratocarcinoma D018243 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Eye Abnormalities D005124 7 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Thrombocythemia, Essential D013920 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Japtok L et al. Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. 2015 FASEB J. pmid:25911610
Stone ML et al. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25910934
Farnoud AM et al. The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. 2015 Infect. Immun. pmid:25895971
Chimen M et al. Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. 2015 Nat. Med. pmid:25894827
Pulli I et al. A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⁺ microdomain in the caveolar compartment. 2015 Biochim. Biophys. Acta pmid:25892494
Urtz N et al. Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. 2015 Circ. Res. pmid:26129975
Zankov DP and Ogita H Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. 2015 Biomed Res Int pmid:25883953
Williams PA et al. Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). 2015 PLoS ONE pmid:25875493
Moolenaar WH Introduction to the ECR special issue on lysophospholipids in biology. 2015 Exp. Cell Res. pmid:25746723
Muñoz-Sáez E et al. Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). 2015 Neurosci. Lett. pmid:25769802
Kang H et al. The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension. 2015 Stem Cells Dev. pmid:25761906
Carrera I et al. A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease. 2015 Biomed Res Int pmid:25759822
Ueda N Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. 2015 Int J Mol Sci pmid:25751724
Hsu CK et al. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. 2015 J. Cell. Physiol. pmid:25201048
Zhao S and Li J Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway. 2015 PLoS ONE pmid:25748447
Lin CC et al. Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. 2015 PLoS ONE pmid:25734900
Zhang DD et al. Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. 2015 Biol. Chem. pmid:25720064
Schröder M et al. Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. 2015 Biol. Chem. pmid:25720062
Koch A et al. Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. 2015 Biol. Chem. pmid:25719311
Park ES et al. Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. 2015 J. Biol. Chem. pmid:25716317
Rhee SH et al. Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. 2015 J Obstet Gynaecol pmid:25692679
Oskeritzian CA et al. The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. 2015 J. Allergy Clin. Immunol. pmid:25512083
Kurano M et al. LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate. 2015 J. Biol. Chem. pmid:25505264
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Konstantinou D et al. Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor. 2015 Cell Biol. Int. pmid:25492631
Pyne NJ and Kolesnick RN The life and work of Dr. Robert Bittman (1942-2014). 2015 Biol. Chem. pmid:25473803
Hashimoto Y et al. Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. 2015 Mol. Cell. Biochem. pmid:25445169
Carroll B et al. Sphingolipids in the DNA damage response. 2015 Adv Biol Regul pmid:25434743
Xiu L et al. Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors. 2015 Am. J. Pathol. pmid:25432063
Benesch MG et al. Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. 2015 J. Lipid Res. pmid:25896349
Hernández-Coronado CG et al. Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. 2015 Animal pmid:25245232
Sar JI et al. Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. 2015 J. Formos. Med. Assoc. pmid:24035571
Sano N et al. New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. 2015 World J. Gastroenterol. pmid:26668502
Iwabuchi K et al. Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. 2015 Mediators Inflamm. pmid:26609196
Ramos-Perez WD et al. A map of the distribution of sphingosine 1-phosphate in the spleen. 2015 Nat. Immunol. pmid:26502404
Winkler MS et al. Decreased serum concentrations of sphingosine-1-phosphate in sepsis. 2015 Crit Care pmid:26498205
Matula K et al. Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. 2015 BMC Cancer pmid:26493335
Barnawi J et al. Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). 2015 PLoS ONE pmid:26485657
Moruno Manchon JF et al. Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy. 2015 Sci Rep pmid:26477494
Deng Z et al. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. 2015 Nat Commun pmid:25907800
Wang K et al. Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. 2015 PLoS Genet. pmid:26474409
Jeong JK et al. Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes. 2015 Mol Med Rep pmid:26459774
Sutter I et al. Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. 2015 Atherosclerosis pmid:26093887
Kihara Y et al. Lysophospholipid receptors in drug discovery. 2015 Exp. Cell Res. pmid:25499971
Boczkowska-Radziwon B et al. Ozonation of human blood increases sphingosine-1-phosphate in plasma. 2015 J. Physiol. Pharmacol. pmid:25903957
Le Bihan O et al. Visualization of adherent cell monolayers by cryo-electron microscopy: A snapshot of endothelial adherens junctions. 2015 J. Struct. Biol. pmid:26470813
Li C et al. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. 2015 J Neuroinflammation pmid:25880547
Dai L et al. Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression. 2015 Oncotarget pmid:26327294
Simón MV et al. Sphingosine-1-Phosphate Is a Crucial Signal for Migration of Retina Müller Glial Cells. 2015 Invest. Ophthalmol. Vis. Sci. pmid:26325420
Yang L et al. Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice. 2015 Sci Rep pmid:26324256
Brünnert D et al. Sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells. 2015 Placenta pmid:26321412
Zhao YD et al. A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung. 2015 PLoS ONE pmid:26317340
Cantalupo A et al. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. 2015 Nat. Med. pmid:26301690
Adamiak M et al. Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. 2015 Oncotarget pmid:26299919
Mori H et al. Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis. 2015 Am. J. Pathol. pmid:26272361
Camp SM et al. Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. 2015 Chem. Phys. Lipids pmid:26272033
Denimal D et al. Significant abnormalities of the HDL phosphosphingolipidome in type 1 diabetes despite normal HDL cholesterol concentration. 2015 Atherosclerosis pmid:26142685
Yagi K et al. Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. 2015 Stroke pmid:26138121
Nakagawa Y and Chiba K Diversity and plasticity of microglial cells in psychiatric and neurological disorders. 2015 Pharmacol. Ther. pmid:26129625
Jeong SK et al. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. 2015 J. Dermatol. Sci. pmid:26113114
Marycz K et al. The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells--new opportunities in regenerative medicine. 2015 Cell. Mol. Biol. Lett. pmid:26110483
Chen MH et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. 2015 Oncotarget pmid:26090720
Panneer Selvam S et al. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. 2015 Sci Signal pmid:26082434
Malik FA et al. Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. 2015 PLoS ONE pmid:26079370
Mooren OL et al. Role of N-WASP in Endothelial Monolayer Formation and Integrity. 2015 J. Biol. Chem. pmid:26070569
El-Najjar N et al. Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. 2015 PLoS ONE pmid:26466367
Hyder CL et al. Sphingolipids inhibit vimentin-dependent cell migration. 2015 J. Cell. Sci. pmid:25908861
Camaré C et al. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. 2015 Br. J. Pharmacol. pmid:25176316
Brait VH et al. Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. 2016 Stroke pmid:27827329
Zamora-Pineda J et al. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. 2016 J. Exp. Med. pmid:27810923
Kobayashi N et al. Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. 2016 J. Lipid Res. pmid:27655910
Evangelisti C et al. Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. 2016 Leukemia pmid:27461062
Chew WS et al. To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. 2016 Pharmacol. Res. pmid:27663260
Wang X et al. Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. 2016 PLoS Pathog. pmid:27711202
Adamiak M et al. The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. 2016 Stem Cell Rev pmid:27704316
Poissonnier A et al. CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. 2016 Immunity pmid:27438772
Zhang Q et al. Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. 2016 Am. J. Chin. Med. pmid:27430910
Adamiak M et al. Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. 2016 Cell Transplant pmid:27412411
Liu X et al. ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. 2016 J. Physiol. Biochem. pmid:27377933
Fleming JK et al. A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. 2016 J. Lipid Res. pmid:27444045
Tong S et al. Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. 2016 J. Biol. Chem. pmid:27405756
Nagura Y et al. Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. 2016 Transfus Med pmid:27350440
Crespo I et al. Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. 2016 J. Pineal Res. pmid:27101794
Riganti L et al. Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. 2016 J. Neurosci. pmid:27098703
Cai Y et al. FOXF1 maintains endothelial barrier function and prevents edema after lung injury. 2016 Sci Signal pmid:27095594
Castaldi A et al. Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. 2016 Cell. Signal. pmid:27094722
Anbazhagan AN et al. Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. 2016 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:27079615
Koresawa R et al. Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. 2016 Br. J. Haematol. pmid:27061580
Li J et al. Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. 2016 Tumour Biol. pmid:26857281
Camaré C et al. The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. 2016 Free Radic. Biol. Med. pmid:26855418
Kim SE et al. The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. 2016 Invest. Ophthalmol. Vis. Sci. pmid:26830367
Messias CV et al. Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. 2016 PLoS ONE pmid:26824863
Pászti-Gere E et al. Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. 2016 Oxid Med Cell Longev pmid:26823955
Wiltshire R et al. Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. 2016 Sci Rep pmid:26813587
Maczis M et al. Sphingosine-1-phosphate and estrogen signaling in breast cancer. 2016 Adv Biol Regul pmid:26601898
Zhang F et al. Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:26589326
Pyne NJ and Tigyi GJ A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. 2016 Prog. Lipid Res. pmid:26584871
Rana A and Sharma S Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. 2016 Clin. Exp. Pharmacol. Physiol. pmid:26582369
Kurano M et al. Resveratrol exerts a biphasic effect on apolipoprotein M. 2016 Br. J. Pharmacol. pmid:26445217
Nojima H et al. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. 2016 J. Hepatol. pmid:26254847