Kulinski JM et al. |
Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. |
2016 |
Eur. J. Pharmacol. |
pmid:25941085
|
Kasbi-Chadli F et al. |
Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. |
2016 |
Eur J Nutr |
pmid:25787885
|
Terashita T et al. |
Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. |
2016 |
Respir. Res. |
pmid:27829417
|
Brait VH et al. |
Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. |
2016 |
Stroke |
pmid:27827329
|
Zamora-Pineda J et al. |
Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. |
2016 |
J. Exp. Med. |
pmid:27810923
|
Kobayashi N et al. |
Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. |
2016 |
J. Lipid Res. |
pmid:27655910
|
Evangelisti C et al. |
Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. |
2016 |
Leukemia |
pmid:27461062
|
Tsuchida J et al. |
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. |
2016 |
J. Surg. Res. |
pmid:27621003
|
Chen W et al. |
Sphingosine 1-phosphate in metabolic syndrome (Review). |
2016 |
Int. J. Mol. Med. |
pmid:27600830
|
Hamidi Shishavan M et al. |
Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. |
2016 |
PLoS ONE |
pmid:27583547
|
Gazit SL et al. |
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. |
2016 |
Circ. Res. |
pmid:27582371
|
Machida T et al. |
Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. |
2016 |
J. Pharmacol. Sci. |
pmid:27581589
|
Nagahashi M et al. |
High levels of sphingolipids in human breast cancer. |
2016 |
J. Surg. Res. |
pmid:27565080
|
Chen C et al. |
Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. |
2016 |
Mol. Cell. Endocrinol. |
pmid:26948947
|
Chakrabarti SS et al. |
Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. |
2016 |
Curr Alzheimer Res |
pmid:27335046
|
Tsai HC and Han MH |
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. |
2016 |
Drugs |
pmid:27318702
|
Yang Z et al. |
TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. |
2016 |
Pharmacol. Res. |
pmid:27317945
|
Cantalupo A and Di Lorenzo A |
S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. |
2016 |
J. Pharmacol. Exp. Ther. |
pmid:27317800
|
Juif PE et al. |
Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. |
2016 |
Expert Opin Drug Metab Toxicol |
pmid:27249325
|
Hollands A et al. |
Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. |
2016 |
J. Biol. Chem. |
pmid:27226531
|
Mirzaian M et al. |
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
2016 |
Clin. Chim. Acta |
pmid:27221202
|
Aoki M et al. |
Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. |
2016 |
Mediators Inflamm. |
pmid:26966342
|
Brinck JW et al. |
Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. |
2016 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:26966278
|
Chawla S et al. |
S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. |
2016 |
IUBMB Life |
pmid:26959531
|
Vito CD et al. |
Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. |
2016 |
Platelets |
pmid:26950429
|
Jin J et al. |
Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. |
2016 |
Sci Rep |
pmid:26948042
|
Guerrero M et al. |
Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). |
2016 |
Expert Opin Ther Pat |
pmid:26947494
|
Watterson SH et al. |
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. |
2016 |
J. Med. Chem. |
pmid:26924461
|
Puli MR et al. |
Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. |
2016 |
Planta |
pmid:27233507
|
Dillmann C et al. |
S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. |
2016 |
J. Immunol. |
pmid:26783340
|
Ghasemi R et al. |
Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage. |
2016 |
Pharmacol. Res. |
pmid:26772814
|
Morel S et al. |
Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. |
2016 |
Cardiovasc. Res. |
pmid:26762268
|
Sundaram K et al. |
Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. |
2016 |
Biochem. J. |
pmid:26747710
|
Abu Khweek A et al. |
The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. |
2016 |
PLoS ONE |
pmid:26741365
|
Deniz U et al. |
A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. |
2016 |
J. Mol. Graph. Model. |
pmid:26724452
|
Beach JA et al. |
Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. |
2016 |
Oncotarget |
pmid:26716409
|
Deutsch G et al. |
Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. |
2016 |
Gene |
pmid:26707209
|
Kim YH and Tabata Y |
Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. |
2016 |
J Biomed Mater Res A |
pmid:26704185
|
Nagahashi M et al. |
DNA damage response and sphingolipid signaling in liver diseases. |
2016 |
Surg. Today |
pmid:26514817
|
Grammatikos G et al. |
Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. |
2016 |
Oncotarget |
pmid:26933996
|
Filipenko I et al. |
Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
2016 |
Biochim. Biophys. Acta |
pmid:27616330
|
Ogle ME et al. |
Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. |
2017 |
Stem Cells |
pmid:28026131
|
Yung BS et al. |
Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. |
2017 |
J. Mol. Cell. Cardiol. |
pmid:28017639
|
Contaifer D et al. |
Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients. |
2017 |
J. Lipid Res. |
pmid:27993949
|
Myśliwiec H et al. |
Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. |
2017 |
Arch. Dermatol. Res. |
pmid:27988894
|
McLean CJ et al. |
Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
2017 |
J. Lipid Res. |
pmid:27784725
|
Abraham C et al. |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
2017 |
Gastroenterology |
pmid:27780712
|
Pal SK et al. |
A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
pmid:27727447
|
Vogt D and Stark H |
Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
2017 |
Med Res Rev |
pmid:27480072
|
Doan NB et al. |
Acid ceramidase confers radioresistance to glioblastoma cells. |
2017 |
Oncol. Rep. |
pmid:28765947
|
Arish M et al. |
Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. |
2017 |
J. Recept. Signal Transduct. Res. |
pmid:28758826
|
Polzin A et al. |
Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
2017 |
J. Mol. Cell. Cardiol. |
pmid:28709768
|
Innamorati G et al. |
Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. |
2017 |
Cell Death Dis |
pmid:28703804
|
Bougault C et al. |
Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
2017 |
Bone |
pmid:28684192
|
Tsai CH et al. |
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
pmid:28672103
|
Schmidt KG et al. |
Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
2017 |
Front Immunol |
pmid:29033951
|
Xie Z et al. |
Targeting sphingosine-1-phosphate signaling for cancer therapy. |
2017 |
Sci China Life Sci |
pmid:28623546
|
Yanagida K et al. |
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. |
2017 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:28396408
|
Takahashi C et al. |
Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. |
2017 |
J. Atheroscler. Thromb. |
pmid:28321011
|
Pierucci F et al. |
Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
2017 |
Neuropharmacology |
pmid:28077289
|
Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
pmid:27823573
|
Roch L et al. |
High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
2017 |
Mol. Neurobiol. |
pmid:27631876
|
Vu TM et al. |
Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
2017 |
Nature |
pmid:29045386
|
Reinhard NR et al. |
The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
2017 |
Mol. Biol. Cell |
pmid:28954861
|
Natarajan V et al. |
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
2017 |
BMC Genomics |
pmid:28851267
|
Hajny S and Christoffersen C |
A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
2017 |
Int J Mol Sci |
pmid:28749426
|
Alqinyah M et al. |
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
2017 |
Mol. Pharmacol. |
pmid:28031332
|
Winkler MS et al. |
Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
2017 |
Shock |
pmid:27922551
|
Chen T et al. |
Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
pmid:27814635
|
Beider K et al. |
The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
2017 |
Clin. Cancer Res. |
pmid:27697999
|
Feuerborn R et al. |
High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
2017 |
Atherosclerosis |
pmid:28038379
|
Thieme M et al. |
Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. |
2017 |
Exp. Dermatol. |
pmid:27574180
|
Chang N et al. |
HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
2017 |
J. Mol. Med. |
pmid:27543493
|
Gudipaty SA and Rosenblatt J |
Epithelial cell extrusion: Pathways and pathologies. |
2017 |
Semin. Cell Dev. Biol. |
pmid:27212253
|
Wang X et al. |
Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
2017 |
Exp. Mol. Pathol. |
pmid:28986246
|
Werth S et al. |
Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
2017 |
J. Endocrinol. |
pmid:28970286
|
Du Y et al. |
Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
2017 |
Cell. Physiol. Biochem. |
pmid:28934733
|
Kuchler L et al. |
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
2017 |
Mol. Immunol. |
pmid:28846923
|
Nicholas SE et al. |
Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
pmid:28806736
|
Lee SY et al. |
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
2017 |
Diabetes |
pmid:28698261
|
Hutami IR et al. |
Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28687489
|
Cannavo A et al. |
β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. |
2017 |
J. Am. Coll. Cardiol. |
pmid:28683966
|
Punsawad C and Viriyavejakul P |
Reduction in serum sphingosine 1-phosphate concentration in malaria. |
2017 |
PLoS ONE |
pmid:28666023
|
Luo J et al. |
The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28655617
|
Chang CH and Randolph GJ |
Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. |
2017 |
Dev. Cell |
pmid:28633013
|
Fang R et al. |
Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. |
2017 |
Arch. Med. Res. |
pmid:28625317
|
Andrieu G et al. |
Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
pmid:28351953
|
Becker S et al. |
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
pmid:28334008
|
Karunakaran I and van Echten-Deckert G |
Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
pmid:28315304
|
Navarrete A et al. |
A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
2017 |
J Pharm Biomed Anal |
pmid:28314215
|
Shirakawa H et al. |
Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
|
Dyckman AJ |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
2017 |
J. Med. Chem. |
pmid:28291340
|
Nielsen OH et al. |
Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. |
2017 |
Trends Mol Med |
pmid:28283249
|
Peyrin-Biroulet L et al. |
Modulation of sphingosine-1-phosphate in inflammatory bowel disease. |
2017 |
Autoimmun Rev |
pmid:28279838
|
Miller M et al. |
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. |
2017 |
J. Immunol. |
pmid:28275141
|
Tafelmeier M et al. |
Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27163393
|
Su K et al. |
FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. |
2017 |
Mediators Inflamm. |
pmid:28270699
|
Serafimidis I et al. |
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. |
2017 |
PLoS Biol. |
pmid:28248965
|
Lee HM et al. |
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. |
2017 |
J. Pathol. |
pmid:28240350
|
Rieck M et al. |
Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. |
2017 |
Eur. J. Immunol. |
pmid:28198542
|