| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Fabry Disease | D000795 | 4 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hojjati MR et al. | Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. | 2005 | J. Biol. Chem. | pmid:15590644 |
| Davis MD et al. | Sphingosine 1-phosphate analogs as receptor antagonists. | 2005 | J. Biol. Chem. | pmid:15590668 |
| Lee MS et al. | Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590895 |
| Watterson KR et al. | The role of sphingosine-1-phosphate in smooth muscle contraction. | 2005 | Cell. Signal. | pmid:15567060 |
| Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
| Schwab SR et al. | Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | 2005 | Science | pmid:16151014 |
| Donati C et al. | Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. | 2005 | FASEB J. | pmid:15625079 |
| Urata Y et al. | Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. | 2005 | Kobe J Med Sci | pmid:16199931 |
| Hughes SK et al. | Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. | 2005 | Ann Biomed Eng | pmid:16133909 |
| Foss FW et al. | Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16125386 |
| Tani M et al. | Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. | 2005 | J. Biol. Chem. | pmid:16126722 |
| Katkade V et al. | Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt. | 2005 | Thromb. Haemost. | pmid:16268479 |
| Wei SH et al. | Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. | 2005 | Nat. Immunol. | pmid:16273098 |
| Lee HS et al. | Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. | 2005 | Cell Calcium | pmid:16219349 |
| Chalfant CE and Spiegel S | Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. | 2005 | J. Cell. Sci. | pmid:16219683 |
| Bandhuvula P et al. | The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | 2005 | J. Biol. Chem. | pmid:16118221 |
| Kharel Y et al. | Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | 2005 | J. Biol. Chem. | pmid:16093248 |
| Maceyka M et al. | Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099387 |
| Danieli-Betto D et al. | Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15659717 |
| Roth Z and Hansen PJ | Disruption of nuclear maturation and rearrangement of cytoskeletal elements in bovine oocytes exposed to heat shock during maturation. | 2005 | Reproduction | pmid:15695618 |
| Tanski WJ et al. | Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. | 2005 | J. Vasc. Surg. | pmid:15696050 |
| Björklund S et al. | Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. | 2005 | Mol. Cell. Endocrinol. | pmid:15713536 |
| Anelli V et al. | Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. | 2005 | J. Neurochem. | pmid:15715670 |
| Johnstone ED et al. | Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. | 2005 | J. Lipid Res. | pmid:15995175 |
| Rosen H and Goetzl EJ | Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. | 2005 | Nat. Rev. Immunol. | pmid:15999095 |
| Karliner JS | Off the shelf but not mass produced. | 2005 | Chem. Biol. | pmid:15975506 |
| Jo E et al. | S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. | 2005 | Chem. Biol. | pmid:15975516 |
| Li Z et al. | Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967165 |
| Ledent C et al. | Premature ovarian aging in mice deficient for Gpr3. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15956199 |
| Kariya Y et al. | Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | 2005 | Genes Cells | pmid:15938718 |
| Abbey-Hosch SE et al. | Differential regulation of NPR-B/GC-B by protein kinase c and calcium. | 2005 | Biochem. Pharmacol. | pmid:16005434 |
| Pébay A et al. | Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. | 2005 Nov-Dec | Stem Cells | pmid:16081668 |
| Seol GH et al. | Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells. | 2005 Sep-Dec | Endothelium | pmid:16410226 |
| Pan S et al. | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. | 2006 | Chem. Biol. | pmid:17114004 |
| Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
| Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
| Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| Park KS et al. | Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. | 2006 | Mol. Pharmacol. | pmid:16368894 |
| Gardell SE et al. | Emerging medicinal roles for lysophospholipid signaling. | 2006 | Trends Mol Med | pmid:16406843 |
| di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
| Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
| Kang JS et al. | Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. | 2006 | Mol. Pharmacol. | pmid:16354764 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
| Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
| Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
| Yatomi Y | Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | 2006 | Curr. Pharm. Des. | pmid:16472149 |
| Kurobe H et al. | CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | 2006 | Immunity | pmid:16473829 |
| Kitano M et al. | Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. | 2006 | Arthritis Rheum. | pmid:16508938 |