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Targeting sphingosine-1-phosphate for cancer therapy. |
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Br. J. Cancer |
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A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. |
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Chem. Biol. |
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Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. |
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J. Biol. Chem. |
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Zheng DM et al. |
Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide. |
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Hepatology |
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Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. |
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J. Exp. Med. |
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Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries. |
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FASEB J. |
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Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. |
2006 |
Dev. Biol. |
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The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. |
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J. Lipid Res. |
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Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. |
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Naunyn Schmiedebergs Arch. Pharmacol. |
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The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. |
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Eur. J. Immunol. |
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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. |
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Mol. Cell. Biol. |
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Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. |
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Nat. Chem. Biol. |
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Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. |
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J. Cell. Sci. |
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Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. |
2006 |
Endocrinology |
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IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. |
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J. Leukoc. Biol. |
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Membrane guanylyl cyclase receptors: an update. |
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Trends Endocrinol. Metab. |
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. |
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Bioorg. Med. Chem. Lett. |
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Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. |
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Biochem. J. |
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Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. |
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Blood |
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Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. |
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Biochem. Biophys. Res. Commun. |
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Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. |
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Endocrinology |
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Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. |
2006 |
J. Lipid Res. |
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Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. |
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J. Biol. Chem. |
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Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis. |
2006 |
J. Biol. Chem. |
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Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? |
2006 |
Br. J. Pharmacol. |
pmid:16402045
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Mathieson FA and Nixon GF |
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. |
2006 |
Br. J. Pharmacol. |
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Barthomeuf C et al. |
Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. |
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Free Radic. Biol. Med. |
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Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. |
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Circ. Res. |
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Park KS et al. |
Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. |
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Mol. Pharmacol. |
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Emerging medicinal roles for lysophospholipid signaling. |
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Trends Mol Med |
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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. |
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FASEB J. |
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Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. |
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Cell. Mol. Immunol. |
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Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. |
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Mol. Pharmacol. |
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Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. |
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Chem. Biol. Interact. |
pmid:16412405
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Massberg S and von Andrian UH |
Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. |
2006 |
N. Engl. J. Med. |
pmid:16971715
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Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. |
2006 |
Endocrinology |
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Natarajan J et al. |
Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line. |
2006 |
BMC Bioinformatics |
pmid:16901352
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Young N and Van Brocklyn JR |
Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. |
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ScientificWorldJournal |
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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. |
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Biochim. Biophys. Acta |
pmid:16996023
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Minshall RD and Malik AB |
Transport across the endothelium: regulation of endothelial permeability. |
2006 |
Handb Exp Pharmacol |
pmid:16999218
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S1P regulation of ovarian carcinoma invasiveness. |
2006 |
Gynecol. Oncol. |
pmid:16956652
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Bassi R et al. |
Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. |
2006 |
Glia |
pmid:16470810
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Yatomi Y |
Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. |
2006 |
Curr. Pharm. Des. |
pmid:16472149
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Kurobe H et al. |
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. |
2006 |
Immunity |
pmid:16473829
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Kitano M et al. |
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. |
2006 |
Arthritis Rheum. |
pmid:16508938
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Hsieh HL et al. |
Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. |
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J. Cell. Physiol. |
pmid:16508949
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Becciolini L et al. |
Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. |
2006 |
Biochim. Biophys. Acta |
pmid:16510307
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Song HJ et al. |
Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. |
2006 |
Mol. Cells |
pmid:16511346
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Takai S et al. |
Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. |
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J. Cell. Biochem. |
pmid:16514645
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Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. |
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J. Clin. Invest. |
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