Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kawamori T et al. | Role for sphingosine kinase 1 in colon carcinogenesis. | 2009 | FASEB J. | pmid:18824518 |
Peyruchaud O | Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer. | 2009 | Anticancer Agents Med Chem | pmid:19442039 |
Kenagy RD et al. | Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis. | 2009 | J. Vasc. Surg. | pmid:19307078 |
Salinas NR et al. | Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. | 2009 | Pathol. Oncol. Res. | pmid:19214784 |
Choi SK et al. | Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. | 2009 | Cardiovasc. Res. | pmid:19218288 |
Tokumura A et al. | Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | 2009 | Int J Med Sci | pmid:19521548 |
Huang YL et al. | Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells. | 2009 | J. Biochem. | pmid:19692429 |
Antoon JW et al. | Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. | 2009 | J. Med. Chem. | pmid:19694470 |
Hashimoto T et al. | Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis. | 2009 | J. Lipid Res. | pmid:19020339 |
Maeurer C et al. | Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. | 2009 | Cell. Signal. | pmid:19000755 |
Ikeda H et al. | Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. | 2009 | J. Lipid Res. | pmid:18955732 |
Ranty ML et al. | Ceramide production associated with retinal apoptosis after retinal detachment. | 2009 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:18958490 |
Young N et al. | Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. | 2009 | Mol. Cancer Res. | pmid:19147534 |
Weis N et al. | Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. | 2009 | Mol. Biol. Cell | pmid:19129475 |
Chang CL et al. | S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19474291 |
Schulz C et al. | Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease. | 2009 | Microcirculation | pmid:19479622 |
Kimber I et al. | Langerhans cell migration: not necessarily always at the center of the skin sensitization universe. | 2009 | J. Invest. Dermatol. | pmid:19603050 |
Pyne NJ et al. | New aspects of sphingosine 1-phosphate signaling in mammalian cells. | 2009 | Adv. Enzyme Regul. | pmid:19534035 |
Price MM et al. | Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. | 2009 | FASEB J. | pmid:19535686 |
Hu W et al. | Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. | 2009 | J. Lipid Res. | pmid:19369694 |
Miranda GE et al. | Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19357361 |
Tao R et al. | Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19433984 |
Yang G et al. | Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19435851 |
Yin H et al. | Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. | 2009 | J. Biol. Chem. | pmid:19286662 |
Hofmann U et al. | Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. | 2009 | Cardiovasc. Res. | pmid:19416991 |
Ader I et al. | When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. | 2009 | Cancer Res. | pmid:19383898 |
Okajima F et al. | Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I. | 2009 | Endocr. J. | pmid:18753704 |
Brinkmann V | FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system. | 2009 | Br. J. Pharmacol. | pmid:19814729 |
Wojciak JM et al. | The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19815502 |
Jacobson JR | Pharmacologic therapies on the horizon for acute lung injury/acute respiratory distress syndrome. | 2009 | J. Investig. Med. | pmid:19820408 |
Jenne CN et al. | T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. | 2009 | J. Exp. Med. | pmid:19808259 |
Long DA and Price KL | Sphingosine kinase-1: a potential mediator of renal fibrosis. | 2009 | Kidney Int. | pmid:19789541 |
Heo K et al. | Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells. | 2009 | BMB Rep | pmid:19874715 |
Jongsma M et al. | Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). | 2009 | Br. J. Pharmacol. | pmid:19309361 |
Bedia C et al. | Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. | 2009 | Chembiochem | pmid:19226506 |
Rodgers A et al. | Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. | 2009 | Stem Cells Dev. | pmid:19228106 |
Gellings Lowe N et al. | Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. | 2009 | Cardiovasc. Res. | pmid:19228708 |
Garcia JG | Concepts in microvascular endothelial barrier regulation in health and disease. | 2009 | Microvasc. Res. | pmid:19232241 |
Igarashi J and Michel T | Sphingosine-1-phosphate and modulation of vascular tone. | 2009 | Cardiovasc. Res. | pmid:19233865 |
Sattler K and Levkau B | Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. | 2009 | Cardiovasc. Res. | pmid:19233866 |
Scherer M et al. | High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. | 2009 | Clin. Chem. | pmid:19325012 |
Maceyka M et al. | Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. | 2009 | J. Lipid Res. | pmid:18987387 |
Sali M et al. | Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection. | 2009 Jan-Mar | Int J Immunopathol Pharmacol | pmid:19309565 |
Syuto T et al. | Mammalian Diaphanous (mDia) may be involved in the signal transduction of sphingosine-1-phosphate on developing actin stress fiber of human fibroblasts. | 2009 Jul-Aug | Wound Repair Regen | pmid:19614924 |
Maiese K | Choices and outcomes: Extending basic biology to clinical care. | 2009 Jul-Aug | Oxid Med Cell Longev | pmid:20592765 |
Vessey DA et al. | Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning. | 2009 Jul-Aug | Oxid Med Cell Longev | pmid:20592769 |
Voelkel NF and Spiegel S | Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma. | 2009 Nov-Dec | Immunol. Cell Biol. | pmid:19546879 |
Hannoun A et al. | Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation. | 2010 | Reprod. Biomed. Online | pmid:20093086 |
Murakami A et al. | Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. | 2010 | Mol. Pharmacol. | pmid:20097776 |
Bektas M et al. | Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. | 2010 | J. Biol. Chem. | pmid:20097939 |
Riccio A | New endogenous regulators of class I histone deacetylases. | 2010 | Sci Signal | pmid:20051592 |
Brown M et al. | Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. | 2010 | Microvasc. Res. | pmid:20053363 |
Fletcher JI et al. | ABC transporters in cancer: more than just drug efflux pumps. | 2010 | Nat. Rev. Cancer | pmid:20075923 |
Egom EE et al. | Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling. | 2010 | Prog. Biophys. Mol. Biol. | pmid:20080123 |
Claas RF et al. | Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2010 | Cell. Signal. | pmid:19913094 |
Park SW et al. | Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. | 2010 | Shock | pmid:19752779 |
Brakch N et al. | Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease. | 2010 | Eur. Heart J. | pmid:19773225 |
Medlin MD et al. | Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20702813 |
Nishimura B et al. | The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. | 2010 | Neurosci. Lett. | pmid:20709153 |
Swan DJ et al. | Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. | 2010 | J. Cell. Mol. Med. | pmid:20716131 |
Nelson CJ et al. | Global analysis of circulating metabolites in hibernating ground squirrels. | 2010 | Comp. Biochem. Physiol. Part D Genomics Proteomics | pmid:20728417 |
Yonesu K et al. | A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate. | 2010 | Biol. Pharm. Bull. | pmid:20823564 |
Morishige J et al. | A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20213695 |
Chen JH et al. | Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival. | 2010 | J. Lipid Res. | pmid:19965613 |
Gorbunova E et al. | Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. | 2010 | J. Virol. | pmid:20463083 |
Shea BS et al. | Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20081052 |
Okae H and Iwakura Y | Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. | 2010 | Dev. Dyn. | pmid:20186915 |
Nam JH et al. | Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells. | 2010 | Mol. Cells | pmid:20069383 |
Vessey DA et al. | Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning. | 2010 | J. Cardiovasc. Pharmacol. Ther. | pmid:20200324 |
Lee H et al. | Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate. | 2010 | Stem Cells | pmid:20201063 |
Qi X et al. | Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. | 2010 | Eur. J. Pharmacol. | pmid:20206620 |
Xu R et al. | Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. | 2010 | FASEB J. | pmid:20207939 |
Hu WM et al. | Effect of S1P5 on proliferation and migration of human esophageal cancer cells. | 2010 | World J. Gastroenterol. | pmid:20397263 |
Ratajczak MZ et al. | Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. | 2010 | Leukemia | pmid:20357827 |
Chiba Y et al. | SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. | 2010 | J. Pharmacol. Sci. | pmid:20948165 |
Alford SK et al. | Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. | 2010 | Ann Biomed Eng | pmid:20358290 |
Kanno T et al. | Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. | 2010 | Neuroscience | pmid:20950672 |
Browne CD et al. | SHEP1 partners with CasL to promote marginal zone B-cell maturation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20956287 |
Zhang N et al. | FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. | 2010 | Autophagy | pmid:20935520 |
Liu G et al. | The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. | 2010 | Nat. Immunol. | pmid:20852647 |
Scherer EQ et al. | Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling. | 2010 | Stroke | pmid:20930159 |
Greco E et al. | Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells. | 2010 | Immunology | pmid:19878354 |
Norman E et al. | Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. | 2010 | J. Neurochem. | pmid:20456020 |
Cao C et al. | The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. | 2010 | J. Clin. Invest. | pmid:20458145 |
Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
Itoh R et al. | Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. | 2010 | J. Bone Miner. Metab. | pmid:20458606 |
Yoshida T et al. | Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20431071 |
Shayman JA | The riddle of the sphinx redux. | 2010 | Kidney Int. | pmid:20431574 |
Hirahara K et al. | Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. | 2010 | Cytokine Growth Factor Rev. | pmid:21084214 |
Kułakowska A et al. | Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis. | 2010 | Neurosci. Lett. | pmid:20434523 |
Szczepaniak WS et al. | S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20435688 |
Rosa JM et al. | Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells. | 2010 | Pflugers Arch. | pmid:20640579 |
Cuvillier O et al. | Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting. | 2010 | Curr Mol Pharmacol | pmid:20302564 |
Long JS et al. | Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. | 2010 | Mol. Cell. Biol. | pmid:20516217 |
Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
Seo YJ et al. | Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. | 2010 | J. Virol. | pmid:20519401 |
Lee MH et al. | HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate. | 2010 | J. Lipid Res. | pmid:20522601 |
Blom T et al. | An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival. | 2010 | BMC Cell Biol. | pmid:20573281 |
Alvarez SE et al. | Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. | 2010 | Nature | pmid:20577214 |
Kamradt T and Frey O | Arthritis: where are the T cells? | 2010 | Arthritis Res. Ther. | pmid:20537200 |