Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bode C et al. | Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. | 2010 | J. Cell. Biochem. | pmid:20186882 |
Ikeda H et al. | Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. | 2010 | Clin. Chim. Acta | pmid:20188085 |
Pereira JP et al. | A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. | 2010 | PLoS ONE | pmid:20174580 |
Yu XQ et al. | Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate. | 2010 | Xenobiotica | pmid:20175664 |
Aydin M et al. | The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. | 2010 | BJU Int. | pmid:20128782 |
Hannoun A et al. | Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation. | 2010 | Reprod. Biomed. Online | pmid:20093086 |
Murakami A et al. | Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. | 2010 | Mol. Pharmacol. | pmid:20097776 |
Bektas M et al. | Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. | 2010 | J. Biol. Chem. | pmid:20097939 |
Riccio A | New endogenous regulators of class I histone deacetylases. | 2010 | Sci Signal | pmid:20051592 |
Brown M et al. | Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. | 2010 | Microvasc. Res. | pmid:20053363 |
Claas RF et al. | Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2010 | Cell. Signal. | pmid:19913094 |
Su SC et al. | Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. | 2010 | J. Biol. Chem. | pmid:20947498 |
Chi XX and Nicol GD | The sphingosine 1-phosphate receptor, S1PRâ‚, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. | 2010 | J. Neurophysiol. | pmid:20844107 |
Józefowski S et al. | Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide. | 2010 | J. Immunol. | pmid:21041721 |
Wuertz CM et al. | p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. | 2010 | FASEB J. | pmid:20739613 |
Park SW et al. | Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. | 2010 | Shock | pmid:19752779 |
Brakch N et al. | Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease. | 2010 | Eur. Heart J. | pmid:19773225 |
Chumanevich AA et al. | Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. | 2010 | Carcinogenesis | pmid:20688834 |
Bourquin F et al. | Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. | 2010 | Structure | pmid:20696404 |
Hoefer J et al. | Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. | 2010 | Circ. Res. | pmid:20671234 |
Tengood JE et al. | Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. | 2010 | Biomaterials | pmid:20674008 |
Jee BC et al. | Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts. | 2010 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:20674140 |
Zhang G et al. | Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20729401 |
Medlin MD et al. | Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20702813 |
Nishimura B et al. | The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. | 2010 | Neurosci. Lett. | pmid:20709153 |
Swan DJ et al. | Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. | 2010 | J. Cell. Mol. Med. | pmid:20716131 |
Morishige J et al. | A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20213695 |
Ponnusamy S et al. | Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. | 2010 | Future Oncol | pmid:21062159 |
Howard C et al. | Dental pulp stem cell migration. | 2010 | J Endod | pmid:21092813 |
Rhee S et al. | Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. | 2010 | Exp. Cell Res. | pmid:19796636 |
Chao HH et al. | L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation. | 2010 | J. Nutr. Biochem. | pmid:19447019 |
Roviezzo F et al. | Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19556602 |
Chen JH et al. | Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival. | 2010 | J. Lipid Res. | pmid:19965613 |
Gorbunova E et al. | Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. | 2010 | J. Virol. | pmid:20463083 |
Shea BS et al. | Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20081052 |
He X et al. | Deregulation of sphingolipid metabolism in Alzheimer's disease. | 2010 | Neurobiol. Aging | pmid:18547682 |
Scott EA et al. | Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. | 2010 | Acta Biomater | pmid:19607945 |
Okae H and Iwakura Y | Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. | 2010 | Dev. Dyn. | pmid:20186915 |
Long JS et al. | Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. | 2010 | J. Biol. Chem. | pmid:20837468 |
Nam JH et al. | Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells. | 2010 | Mol. Cells | pmid:20069383 |
Deshpande GP et al. | Effects of sphingosine-1-phosphate on acute contractile heart failure (ACHF). | 2010 | Cardiovasc Drugs Ther | pmid:20838867 |
Gil PR et al. | Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₠and S1P₃ and Smad-signalling. | 2010 | Cytoskeleton (Hoboken) | pmid:20857421 |
Dudek SM et al. | Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. | 2010 | Mol. Biol. Cell | pmid:20861316 |
Lan T et al. | Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. | 2010 | Biomed. Chromatogr. | pmid:20352614 |
Förster A et al. | Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. | 2010 | Kidney Int. | pmid:20375982 |
Vessey DA et al. | Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning. | 2010 | J. Cardiovasc. Pharmacol. Ther. | pmid:20200324 |
Strub GM et al. | Extracellular and intracellular actions of sphingosine-1-phosphate. | 2010 | Adv. Exp. Med. Biol. | pmid:20919652 |
Lee H et al. | Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate. | 2010 | Stem Cells | pmid:20201063 |
Oskouian B and Saba JD | Cancer treatment strategies targeting sphingolipid metabolism. | 2010 | Adv. Exp. Med. Biol. | pmid:20919655 |
Qi X et al. | Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. | 2010 | Eur. J. Pharmacol. | pmid:20206620 |
Wang F et al. | Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. | 2010 | J. Clin. Invest. | pmid:20978351 |
Xu R et al. | Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. | 2010 | FASEB J. | pmid:20207939 |
Chiba Y et al. | SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. | 2010 | J. Pharmacol. Sci. | pmid:20948165 |
Kanno T et al. | Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. | 2010 | Neuroscience | pmid:20950672 |
Browne CD et al. | SHEP1 partners with CasL to promote marginal zone B-cell maturation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20956287 |
Zhang N et al. | FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. | 2010 | Autophagy | pmid:20935520 |
Greco E et al. | Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells. | 2010 | Immunology | pmid:19878354 |
Serra M and Saba JD | Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. | 2010 | Adv. Enzyme Regul. | pmid:19914275 |
Yamamoto Y et al. | Increased expression of enzymes for sphingosine 1-phosphate turnover and signaling in human decidua during late pregnancy. | 2010 | Biol. Reprod. | pmid:20007411 |
Wang S et al. | A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. | 2010 | Glycobiology | pmid:20008963 |
McDonald RA et al. | The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | 2010 | Br. J. Pharmacol. | pmid:20015089 |
Herzog C et al. | Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. | 2010 | Mediators Inflamm. | pmid:21274265 |
Bonnaud S et al. | Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. | 2010 | Cancer Res. | pmid:21118968 |
Coelho RP et al. | Sphingosine-1-phosphate and oligodendrocytes: from cell development to the treatment of multiple sclerosis. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:19808013 |
Norman E et al. | Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. | 2010 | J. Neurochem. | pmid:20456020 |
Cao C et al. | The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. | 2010 | J. Clin. Invest. | pmid:20458145 |
Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
Itoh R et al. | Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. | 2010 | J. Bone Miner. Metab. | pmid:20458606 |
Yoshida T et al. | Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20431071 |
Ohno T et al. | The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling. | 2010 | Biopharm Drug Dispos | pmid:20623701 |
Gurgui M et al. | Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells. | 2010 | Cell. Signal. | pmid:20624458 |
He X et al. | Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue-derived stem cells. | 2010 | J Mol Cell Biol | pmid:20584786 |
Thangada S et al. | Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. | 2010 | J. Exp. Med. | pmid:20584883 |
Baker DA et al. | Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. | 2010 | J. Immunol. | pmid:20644167 |
Lan T et al. | Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. | 2010 | Arch. Biochem. Biophys. | pmid:20646989 |
Abrahan CE et al. | Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19797232 |
Seo J et al. | Sphingosine-1-phosphate signaling in human submandibular cells. | 2010 | J. Dent. Res. | pmid:20651091 |
Sattler KJ et al. | Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. | 2010 | Basic Res. Cardiol. | pmid:20652276 |
Kelly RF et al. | Ethanolamine is a novel STAT-3 dependent cardioprotective agent. | 2010 | Basic Res. Cardiol. | pmid:20938668 |
Meacci E et al. | Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. | 2010 | Cell. Mol. Life Sci. | pmid:20614160 |
Sumida GM and Stamer WD | Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592229 |
Cusack KP and Stoffel RH | S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. | 2010 | Curr Opin Drug Discov Devel | pmid:20597031 |
Weis T et al. | Sphingosine 1-phosphate (S1P) induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells. | 2010 | Eur. J. Cell Biol. | pmid:20656374 |
Rosa JM et al. | Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells. | 2010 | Pflugers Arch. | pmid:20640579 |
Cuvillier O et al. | Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting. | 2010 | Curr Mol Pharmacol | pmid:20302564 |
Long JS et al. | Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. | 2010 | Mol. Cell. Biol. | pmid:20516217 |
Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
Seo YJ et al. | Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. | 2010 | J. Virol. | pmid:20519401 |
Lee MH et al. | HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate. | 2010 | J. Lipid Res. | pmid:20522601 |
Ito S et al. | Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19648475 |
Pyne NJ and Pyne S | Sphingosine 1-phosphate and cancer. | 2010 | Nat. Rev. Cancer | pmid:20555359 |
Fyrst H and Saba JD | An update on sphingosine-1-phosphate and other sphingolipid mediators. | 2010 | Nat. Chem. Biol. | pmid:20559316 |
Valentine WJ et al. | (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. | 2010 | Cell. Signal. | pmid:20566326 |
Zhou Y et al. | Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. | 2010 | Stroke | pmid:20508187 |
Pchejetski D et al. | Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer. | 2010 | Breast Cancer Res. Treat. | pmid:20535545 |
Leong WI and Saba JD | S1P metabolism in cancer and other pathological conditions. | 2010 | Biochimie | pmid:20167244 |
Ma B et al. | Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20188554 |
Gangoiti P et al. | Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. | 2010 | Prog. Lipid Res. | pmid:20193711 |
Tölle M et al. | Relevance of sphingolipids in the pleiotropic protective effects of high-density lipoproteins. | 2010 | Curr. Pharm. Des. | pmid:20196741 |
Weigert A et al. | Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. | 2010 | Blood | pmid:20197547 |