Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bode C et al. | Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. | 2010 | J. Cell. Biochem. | pmid:20186882 |
Ikeda H et al. | Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. | 2010 | Clin. Chim. Acta | pmid:20188085 |
Pereira JP et al. | A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. | 2010 | PLoS ONE | pmid:20174580 |
Yu XQ et al. | Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate. | 2010 | Xenobiotica | pmid:20175664 |
Aydin M et al. | The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. | 2010 | BJU Int. | pmid:20128782 |
Wuertz CM et al. | p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. | 2010 | FASEB J. | pmid:20739613 |
Hoefer J et al. | Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. | 2010 | Circ. Res. | pmid:20671234 |
Tengood JE et al. | Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. | 2010 | Biomaterials | pmid:20674008 |
Jee BC et al. | Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts. | 2010 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:20674140 |
Zhang G et al. | Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20729401 |
Rhee S et al. | Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. | 2010 | Exp. Cell Res. | pmid:19796636 |
Roviezzo F et al. | Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19556602 |
Lan T et al. | Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. | 2010 | Biomed. Chromatogr. | pmid:20352614 |
Förster A et al. | Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. | 2010 | Kidney Int. | pmid:20375982 |
Coelho RP et al. | Sphingosine-1-phosphate and oligodendrocytes: from cell development to the treatment of multiple sclerosis. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:19808013 |
Meacci E et al. | Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. | 2010 | Cell. Mol. Life Sci. | pmid:20614160 |
Sumida GM and Stamer WD | Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592229 |
Cusack KP and Stoffel RH | S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. | 2010 | Curr Opin Drug Discov Devel | pmid:20597031 |
Weis T et al. | Sphingosine 1-phosphate (S1P) induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells. | 2010 | Eur. J. Cell Biol. | pmid:20656374 |
Serebrov VIu et al. | [Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis]. | 2010 Mar-Apr | Biomed Khim | pmid:21341516 |
Knapp M | Cardioprotective role of sphingosine-1-phosphate. | 2011 | J. Physiol. Pharmacol. | pmid:22314562 |
Berdyshev EV et al. | Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. | 2011 | Anal. Biochem. | pmid:20804717 |
Berdyshev EV et al. | Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. | 2011 | PLoS ONE | pmid:21304987 |
Schuchardt M et al. | Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. | 2011 | Br. J. Pharmacol. | pmid:21309759 |
Kikuta J et al. | [Encounter of cancer cells with bone. In vivo imaging of osteoclasts and their precursors in intact bone tissues]. | 2011 | Clin Calcium | pmid:21358058 |
Mair N et al. | Genetic evidence for involvement of neuronally expressed S1Pâ‚ receptor in nociceptor sensitization and inflammatory pain. | 2011 | PLoS ONE | pmid:21359147 |
Ishii T et al. | The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy. | 2011 | Mol. Cells | pmid:21360199 |
Antel J and Hohlfeld R | Modulation of sphingosine 1-phosphate signaling in neurologic disease. | 2011 | Neurology | pmid:21360856 |
Hagen N et al. | Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. | 2011 | Cell Death Differ. | pmid:21331079 |
Meng H et al. | Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia. | 2011 | PLoS ONE | pmid:22096531 |
Yuan L et al. | [The study on protective effect of sphingosine-1-phosphate in cardiomyocytes]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22097726 |
Ling B et al. | Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer. | 2011 | Invest New Drugs | pmid:20041340 |
Kim MG et al. | CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. | 2011 | Nephrol. Dial. Transplant. | pmid:20702533 |
Jiang Z et al. | Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence. | 2011 | Biomed. Chromatogr. | pmid:20812204 |
Durafourt BA et al. | Differential responses of human microglia and blood-derived myeloid cells to FTY720. | 2011 | J. Neuroimmunol. | pmid:20826007 |
Fox TE et al. | Circulating sphingolipid biomarkers in models of type 1 diabetes. | 2011 | J. Lipid Res. | pmid:21068007 |
Wang L et al. | FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. | 2011 | Eur. Respir. J. | pmid:21071472 |
Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
Murakami M et al. | Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. | 2011 | J. Cell. Biochem. | pmid:21769916 |
Yu Y and Qin SC | [An active lipid signaling molecule: sphingosine-1-phosphate and its biological characteristics]. | 2011 | Sheng Li Ke Xue Jin Zhan | pmid:21770269 |
Tanfin Z et al. | ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium. | 2011 | Cell. Signal. | pmid:21803151 |
Gault CR and Obeid LM | Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21787121 |
Qadri SM et al. | Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death. | 2011 | Cell. Physiol. Biochem. | pmid:21865742 |
Kharel Y et al. | Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. | 2011 | Biochem. J. | pmid:21848514 |
GarcÃa-Sáinz JA et al. | Mechanisms involved in α1B-adrenoceptor desensitization. | 2011 | IUBMB Life | pmid:21815242 |
Yang Y and Uhlig S | The role of sphingolipids in respiratory disease. | 2011 | Ther Adv Respir Dis | pmid:21900155 |
Edmonds Y et al. | Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. | 2011 | Pharmacol. Ther. | pmid:21906625 |
Baranowski M and Górski J | Heart sphingolipids in health and disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21910081 |
Hammad SM | Blood sphingolipids in homeostasis and pathobiology. | 2011 | Adv. Exp. Med. Biol. | pmid:21910082 |
Kawahara A | [Genetic dissection of cardiac morphogenesis in zebrafish]. | 2011 | Seikagaku | pmid:21706872 |
Burns TA and Luberto C | Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches. | 2011 | Anticancer Agents Med Chem | pmid:21707485 |
Cuvillier O and Ader I | Hypoxia-inducible factors and sphingosine 1-phosphate signaling. | 2011 | Anticancer Agents Med Chem | pmid:21707486 |
Bedia C et al. | Regulation of autophagy by sphingolipids. | 2011 | Anticancer Agents Med Chem | pmid:21707487 |
Weigert A et al. | S1P regulation of macrophage functions in the context of cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707489 |
Watters RJ et al. | Targeting sphingosine-1-phosphate receptors in cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707490 |
Stevenson CE et al. | Targeting sphingosine-1-phosphate in hematologic malignancies. | 2011 | Anticancer Agents Med Chem | pmid:21707492 |
Bourquin F et al. | PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. | 2011 | Protein Sci. | pmid:21710479 |
Mathew B et al. | Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. | 2011 | FASEB J. | pmid:21712494 |
Olivera A and Rivera J | An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21713655 |
Vessey DA et al. | P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21685263 |
Varo-Sánchez GM et al. | [Pharmacological targets in multiple sclerosis]. | 2011 | Rev Neurol | pmid:21678322 |
Alden KP et al. | Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683064 |
Kennedy AJ et al. | Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. | 2011 | J. Med. Chem. | pmid:21495716 |
Samadi N et al. | Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. | 2011 | Biochimie | pmid:20709140 |
Hla T and Brinkmann V | Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. | 2011 | Neurology | pmid:21339489 |
Soliven B et al. | The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. | 2011 | Neurology | pmid:21339490 |
Brecht K et al. | Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. | 2011 | FASEB J. | pmid:21450910 |
Benamer N et al. | Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21420933 |
Ocaña-Morgner C et al. | Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA. | 2011 | J. Immunol. | pmid:21421853 |
Kato K et al. | Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts. | 2011 | Endocrinology | pmid:21427224 |
López-Juárez A et al. | Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. | 2011 | Glia | pmid:21319224 |
Yonamine I et al. | Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. | 2011 | J. Cell Biol. | pmid:21321100 |
Lamana A et al. | CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells. | 2011 | J. Invest. Dermatol. | pmid:21412255 |
Yogi A et al. | Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension. | 2011 | Hypertension | pmid:21383307 |
Zhu Q et al. | A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21478479 |
Takasugi N et al. | BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. | 2011 | J. Neurosci. | pmid:21543615 |
Barra V et al. | Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB. | 2011 | Cell. Mol. Life Sci. | pmid:20949368 |
Greenspon J et al. | Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. | 2011 | Dig. Dis. Sci. | pmid:20936358 |
Lan T et al. | Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21292568 |
McQuiston T et al. | Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages. | 2011 | Microbiology (Reading, Engl.) | pmid:21292747 |
Highkin MK et al. | High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry. | 2011 | J Biomol Screen | pmid:21297110 |
Bolli MH et al. | Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls. | 2011 | Curr Top Med Chem | pmid:21261590 |
Hopson KP et al. | S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21270296 |
Cahalan SM et al. | Actions of a picomolar short-acting S1Pâ‚ agonist in S1Pâ‚-eGFP knock-in mice. | 2011 | Nat. Chem. Biol. | pmid:21445057 |
Ter Braak M et al. | Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. | 2011 | Biochem. Pharmacol. | pmid:21163254 |
Markiewicz M et al. | Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. | 2011 | Microcirculation | pmid:21166920 |
Sassoli C et al. | Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction. | 2011 | J. Cell. Mol. Med. | pmid:21199328 |
Jang S et al. | Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. | 2011 | Neurochem. Res. | pmid:21076868 |
Hisano Y et al. | The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. | 2011 | J. Biol. Chem. | pmid:21084291 |
Bäumer W et al. | Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. | 2011 | J. Invest. Dermatol. | pmid:20811395 |
Majeed Y et al. | Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. | 2011 | Br. J. Pharmacol. | pmid:21108630 |
Bradley ME et al. | The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications. | 2011 | Eur. J. Pharmacol. | pmid:21970805 |
Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
Kang H et al. | Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. | 2011 | J. Biol. Chem. | pmid:22002053 |
Gomez L et al. | A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection. | 2011 | Basic Res. Cardiol. | pmid:22002221 |
Yester JW et al. | Extracellular and intracellular sphingosine-1-phosphate in cancer. | 2011 | Cancer Metastasis Rev. | pmid:22002715 |
Pyne S et al. | Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. | 2011 | Cancer Res. | pmid:21940750 |
McGuire PG et al. | Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21940944 |
Karuna R et al. | Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism. | 2011 | Atherosclerosis | pmid:21944699 |
Arnon TI et al. | GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. | 2011 | Science | pmid:21960637 |