Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Berdyshev EV et al. | Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. | 2011 | Anal. Biochem. | pmid:20804717 |
Hagen N et al. | Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. | 2011 | Cell Death Differ. | pmid:21331079 |
Meng H et al. | Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia. | 2011 | PLoS ONE | pmid:22096531 |
Yuan L et al. | [The study on protective effect of sphingosine-1-phosphate in cardiomyocytes]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22097726 |
Ling B et al. | Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer. | 2011 | Invest New Drugs | pmid:20041340 |
Lépine S et al. | Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. | 2011 | J. Biol. Chem. | pmid:22052905 |
Kotani M et al. | [Bone and calcium update; bone research update. Trafficking of osteoclast precursors visualized by intravital imaging technology]. | 2011 | Clin Calcium | pmid:22133828 |
Eichner A and Sixt M | Setting the clock for recirculating lymphocytes. | 2011 | Sci Signal | pmid:22067458 |
Durafourt BA et al. | Differential responses of human microglia and blood-derived myeloid cells to FTY720. | 2011 | J. Neuroimmunol. | pmid:20826007 |
Fox TE et al. | Circulating sphingolipid biomarkers in models of type 1 diabetes. | 2011 | J. Lipid Res. | pmid:21068007 |
Wang L et al. | FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. | 2011 | Eur. Respir. J. | pmid:21071472 |
Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
Bieberich E | There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells. | 2011 | Neurochem. Res. | pmid:21136155 |
Kikuta J et al. | S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. | 2011 | Rheumatol. Int. | pmid:21113810 |
Hu PF et al. | Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis. | 2011 | Mol. Biol. Rep. | pmid:21116853 |
Xia P and Wadham C | Sphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling. | 2011 | Cytokine Growth Factor Rev. | pmid:21051273 |
Cho MC et al. | Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. | 2011 | J Sex Med | pmid:21143420 |
Li C et al. | Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. | 2011 | J. Hepatol. | pmid:21145832 |
Zhao Y et al. | Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21148740 |
Qadri SM et al. | Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death. | 2011 | Cell. Physiol. Biochem. | pmid:21865742 |
Kharel Y et al. | Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. | 2011 | Biochem. J. | pmid:21848514 |
GarcÃa-Sáinz JA et al. | Mechanisms involved in α1B-adrenoceptor desensitization. | 2011 | IUBMB Life | pmid:21815242 |
Yang Y and Uhlig S | The role of sphingolipids in respiratory disease. | 2011 | Ther Adv Respir Dis | pmid:21900155 |
Edmonds Y et al. | Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. | 2011 | Pharmacol. Ther. | pmid:21906625 |
Baranowski M and Górski J | Heart sphingolipids in health and disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21910081 |
Hammad SM | Blood sphingolipids in homeostasis and pathobiology. | 2011 | Adv. Exp. Med. Biol. | pmid:21910082 |
Serafimidis I et al. | G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. | 2011 | Mol. Cell. Biol. | pmid:21911471 |
Kim BS et al. | The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21888894 |
Watters RJ et al. | Targeting sphingosine-1-phosphate receptors in cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707490 |
Blaho VA and Hla T | Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. | 2011 | Chem. Rev. | pmid:21939239 |
Stevenson CE et al. | Targeting sphingosine-1-phosphate in hematologic malignancies. | 2011 | Anticancer Agents Med Chem | pmid:21707492 |
Schulze T et al. | Sphingosine-1-phospate receptor 4 (S1Pâ‚„) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. | 2011 | FASEB J. | pmid:21825036 |
Bourquin F et al. | PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. | 2011 | Protein Sci. | pmid:21710479 |
Huwiler A et al. | A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. | 2011 | PLoS ONE | pmid:21829623 |
Mathew B et al. | Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. | 2011 | FASEB J. | pmid:21712494 |
Olivera A and Rivera J | An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21713655 |
Vessey DA et al. | P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21685263 |
Varo-Sánchez GM et al. | [Pharmacological targets in multiple sclerosis]. | 2011 | Rev Neurol | pmid:21678322 |
Alden KP et al. | Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683064 |
Walzer T and Vivier E | G-protein-coupled receptors in control of natural killer cell migration. | 2011 | Trends Immunol. | pmid:21664184 |
Poulsen RR et al. | The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. | 2011 | BMC Dev. Biol. | pmid:21668976 |
Goetzl EJ et al. | Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. | 2011 | J. Clin. Immunol. | pmid:21671128 |
Donati C et al. | Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. | 2011 | PLoS ONE | pmid:21629665 |
Liu X et al. | Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. | 2011 | J. Cell. Physiol. | pmid:21660960 |
Li MH et al. | Sphingolipid modulation of angiogenic factor expression in neuroblastoma. | 2011 | Cancer Prev Res (Phila) | pmid:21576349 |
Bréart B et al. | Lipid phosphate phosphatase 3 enables efficient thymic egress. | 2011 | J. Exp. Med. | pmid:21576386 |
Gu Y et al. | Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. | 2011 | J. Cell Biol. | pmid:21555463 |
Oo ML et al. | Engagement of S1Pâ‚-degradative mechanisms leads to vascular leak in mice. | 2011 | J. Clin. Invest. | pmid:21555855 |
Samadi N et al. | Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. | 2011 | Biochimie | pmid:20709140 |
Kato K et al. | Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts. | 2011 | Endocrinology | pmid:21427224 |
López-Juárez A et al. | Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. | 2011 | Glia | pmid:21319224 |
Yonamine I et al. | Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. | 2011 | J. Cell Biol. | pmid:21321100 |
Lamana A et al. | CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells. | 2011 | J. Invest. Dermatol. | pmid:21412255 |
Yogi A et al. | Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension. | 2011 | Hypertension | pmid:21383307 |
Zhu Q et al. | A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21478479 |
Takasugi N et al. | BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. | 2011 | J. Neurosci. | pmid:21543615 |
Jackson EK | Role of sphingosine-1-phosphate in the renal medulla. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21511695 |
Salas A et al. | Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. | 2011 | Blood | pmid:21527515 |
Cohen JA and Chun J | Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. | 2011 | Ann. Neurol. | pmid:21520239 |
Lim KG et al. | FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. | 2011 | J. Biol. Chem. | pmid:21464128 |
Jung M et al. | Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin. | 2011 | Exp. Dermatol. | pmid:21366697 |
Pyne S and Pyne NJ | Translational aspects of sphingosine 1-phosphate biology. | 2011 | Trends Mol Med | pmid:21514226 |
Lan T et al. | Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21292568 |
McQuiston T et al. | Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages. | 2011 | Microbiology (Reading, Engl.) | pmid:21292747 |
Highkin MK et al. | High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry. | 2011 | J Biomol Screen | pmid:21297110 |
Bolli MH et al. | Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls. | 2011 | Curr Top Med Chem | pmid:21261590 |
Hopson KP et al. | S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21270296 |
Ulrych T et al. | Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation. | 2011 | J. Thromb. Haemost. | pmid:21251196 |
Catarzi S et al. | Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor. | 2011 | Biochim. Biophys. Acta | pmid:21256191 |
Beljanski V et al. | Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. | 2011 | Cancer Biol. Ther. | pmid:21258214 |
Doyle T et al. | Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. | 2011 | Pain | pmid:21239112 |
Bouma HR et al. | Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21245336 |
Aarthi JJ et al. | Dissecting the role of the S1P/S1PR axis in health and disease. | 2011 | J. Dent. Res. | pmid:21248363 |
Sumida GM and Stamer WD | S1Pâ‚‚ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21289286 |
Sensken SC et al. | Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia. | 2011 | J. Immunol. | pmid:21289303 |
Lee SY et al. | Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. | 2011 | Nephrology (Carlton) | pmid:21272128 |
Cahalan SM et al. | Actions of a picomolar short-acting S1Pâ‚ agonist in S1Pâ‚-eGFP knock-in mice. | 2011 | Nat. Chem. Biol. | pmid:21445057 |
Jang S et al. | Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. | 2011 | Neurochem. Res. | pmid:21076868 |
Hisano Y et al. | The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. | 2011 | J. Biol. Chem. | pmid:21084291 |
Bäumer W et al. | Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. | 2011 | J. Invest. Dermatol. | pmid:20811395 |
Majeed Y et al. | Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. | 2011 | Br. J. Pharmacol. | pmid:21108630 |
Chiba Y et al. | Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice. | 2011 | Pharmacol Rep | pmid:21602610 |
Doyle T et al. | Sphingosine-1-phosphate acting via the S1Pâ‚ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. | 2011 | Neurosci. Lett. | pmid:21605625 |
Christoffersen C et al. | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21606363 |
Fenger M et al. | Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. | 2011 | BMC Genet. | pmid:21569466 |
Separovic D et al. | Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21545791 |
Spiegel S and Milstien S | The outs and the ins of sphingosine-1-phosphate in immunity. | 2011 | Nat. Rev. Immunol. | pmid:21546914 |
Argraves KM et al. | S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | 2011 | Lipids Health Dis | pmid:21554699 |
Kang H et al. | Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. | 2011 | J. Biol. Chem. | pmid:22002053 |
Gomez L et al. | A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection. | 2011 | Basic Res. Cardiol. | pmid:22002221 |
Yester JW et al. | Extracellular and intracellular sphingosine-1-phosphate in cancer. | 2011 | Cancer Metastasis Rev. | pmid:22002715 |
Pyne S et al. | Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. | 2011 | Cancer Res. | pmid:21940750 |
McGuire PG et al. | Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21940944 |
Karuna R et al. | Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism. | 2011 | Atherosclerosis | pmid:21944699 |
Arnon TI et al. | GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. | 2011 | Science | pmid:21960637 |
El-Shewy HM et al. | Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. | 2011 | Mol. Endocrinol. | pmid:22016563 |
Sola A et al. | Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration. | 2011 | J. Pathol. | pmid:22025214 |
Wirrig C et al. | Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. | 2011 | J. Cereb. Blood Flow Metab. | pmid:20551970 |
Ruiz-Medina J et al. | GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception. | 2011 Jul-Aug | Neuropharmacology | pmid:21352831 |
Golan K et al. | S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. | 2012 | Blood | pmid:22279055 |