Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Radi ZA and Vogel MW | Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. | 2014 | Toxicol Pathol | pmid:24178572 |
Che W et al. | Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24032470 |
Chang N et al. | Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. | 2014 | J. Cell. Biochem. | pmid:24038457 |
Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
Giannouli CC et al. | Visualizing S1P-directed cellular egress by intravital imaging. | 2014 | Biochim. Biophys. Acta | pmid:24090699 |
Zhang Y et al. | Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. | 2014 | J. Clin. Invest. | pmid:24837436 |
Kurano M et al. | Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. | 2014 | Biochim. Biophys. Acta | pmid:24814049 |
Arya D et al. | Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. | 2014 | J. Biomed. Sci. | pmid:24898615 |
Maceyka M and Spiegel S | Sphingolipid metabolites in inflammatory disease. | 2014 | Nature | pmid:24899305 |
Nagata Y et al. | Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. | 2014 | Exp. Cell Res. | pmid:24960577 |
Ceccom J et al. | [Sphingosine 1-phosphate as a biomarker for Alzheimer's disease?]. | 2014 | Med Sci (Paris) | pmid:24939530 |
Moxon JV et al. | Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. | 2014 | Circ Cardiovasc Genet | pmid:24448739 |
Gorlino CV et al. | Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes. | 2014 | J. Immunol. | pmid:25015824 |
Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
Brünnert D et al. | Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. | 2014 | Mol. Hum. Reprod. | pmid:24994816 |
Nagamatsu T et al. | Emerging roles for lysophospholipid mediators in pregnancy. | 2014 | Am. J. Reprod. Immunol. | pmid:24689547 |
Shimizu Y et al. | Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. | 2014 | Am. J. Pathol. | pmid:24641902 |
Ohotski J et al. | Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. | 2014 | Cell. Signal. | pmid:24486401 |
Takeo T et al. | Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. | 2014 | Cryobiology | pmid:24201107 |
de Assuncao TM et al. | New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. | 2014 | J. Biol. Chem. | pmid:24759103 |
Tibboel J et al. | Sphingolipids in lung growth and repair. | 2014 | Chest | pmid:24394822 |
Huang K et al. | AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. | 2014 | Cell. Signal. | pmid:24342046 |
Slattum G et al. | Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. | 2014 | Curr. Biol. | pmid:24361067 |
Miller DS | Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24385389 |
Xu M et al. | FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. | 2014 | Acta Pharmacol. Sin. | pmid:25399649 |
Watanabe C et al. | Antagonism and synergy of single chain sphingolipids sphingosine and sphingosine-1-phosphate toward lipid bilayer properties. Consequences for their role as cell fate regulators. | 2014 | Langmuir | pmid:25386673 |
Dai L et al. | Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy? | 2014 | Cancer Invest. | pmid:24499107 |
Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
Nakajima C et al. | The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. | 2014 | Development | pmid:25377550 |
Barnes J and Dweik RA | Is pulmonary hypertension a metabolic disease? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25360726 |
Chen J et al. | Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. | 2014 | PLoS Genet. | pmid:25356849 |
Degagné E et al. | Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. | 2014 | J. Clin. Invest. | pmid:25347472 |
Wang F and Ye P | Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. | 2014 | Lipids Health Dis | pmid:25339382 |
Keller J et al. | Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. | 2014 | Nat Commun | pmid:25333900 |
Lepletier A et al. | Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease. | 2014 | PLoS Negl Trop Dis | pmid:25330249 |
Bradley E et al. | Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. | 2014 | PLoS ONE | pmid:25330231 |
Emery SM et al. | Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24259678 |
Sutter I et al. | Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. | 2014 | J. Lipid Res. | pmid:24950692 |
Adamson RH et al. | Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24531813 |
Rosen H et al. | The organization of the sphingosine 1-phosphate signaling system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728591 |
Hanson MA and Peach R | Structural biology of the S1P1 receptor. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728592 |
Cahalan SM | Chemical and genetic tools to explore S1P biology. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728593 |
Arnon TI and Cyster JG | Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728595 |
Oldstone MB and Rosen H | Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728596 |
Yang W et al. | Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. | 2014 | PLoS ONE | pmid:25188412 |
Martin R and Sospedra M | Sphingosine-1 phosphate and central nervous system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728597 |
Chen J et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25180446 |
Kong Y et al. | Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. | 2014 | Mediators Inflamm. | pmid:25147438 |
Shayegi N et al. | CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. | 2014 | Br. J. Haematol. | pmid:24180707 |
Nagahashi M et al. | Sphingosine-1-phosphate transporters as targets for cancer therapy. | 2014 | Biomed Res Int | pmid:25133174 |
Nguyen AV et al. | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. | 2014 | World J. Gastroenterol. | pmid:25132744 |
Kim ES et al. | Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. | 2014 | Oncogene | pmid:23955082 |
Deng Y et al. | Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy. | 2014 | Chin. Med. J. | pmid:25131242 |
Ogle ME et al. | Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. | 2014 | Acta Biomater | pmid:25128750 |
St John AL et al. | S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. | 2014 | Immunity | pmid:25238098 |
Bi Y et al. | Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. | 2014 | Am. J. Pathol. | pmid:25111230 |
Rolin J and Maghazachi AA | Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. | 2014 | J. Leukoc. Biol. | pmid:24493826 |
Schwalm S et al. | Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23789924 |
Tsai YC et al. | Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. | 2014 | Reprod Sci | pmid:23793475 |
Xiong Y and Hla T | S1P control of endothelial integrity. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728594 |
Mendelson K et al. | Sphingosine 1-phosphate signalling. | 2014 | Development | pmid:24346695 |
Rauch BH | Sphingosine 1-phosphate as a link between blood coagulation and inflammation. | 2014 | Cell. Physiol. Biochem. | pmid:24977491 |
Sattler K et al. | HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977490 |
Thuy AV et al. | Sphingosine 1-phosphate in blood: function, metabolism, and fate. | 2014 | Cell. Physiol. Biochem. | pmid:24977489 |
Hait NC et al. | Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. | 2014 | Nat. Neurosci. | pmid:24859201 |
van Echten-Deckert G et al. | Sphingosine-1-phosphate: boon and bane for the brain. | 2014 | Cell. Physiol. Biochem. | pmid:24977488 |
Fayyaz S et al. | Divergent role of sphingosine 1-phosphate on insulin resistance. | 2014 | Cell. Physiol. Biochem. | pmid:24977487 |
Rahman MM et al. | Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. | 2014 | PLoS ONE | pmid:24647471 |
Halmer R et al. | Sphingolipids: important players in multiple sclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977485 |
Park SM et al. | Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. | 2014 | Eur. J. Immunol. | pmid:24825162 |
Arlt O et al. | Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. | 2014 | Cell. Physiol. Biochem. | pmid:24977479 |
Simmons S and Ishii M | Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. | 2014 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:24276789 |
Don AS et al. | Re-configuration of sphingolipid metabolism by oncogenic transformation. | 2014 | Biomolecules | pmid:24970218 |
Snelder N et al. | Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. | 2014 | Drug Metab. Dispos. | pmid:24965813 |
Tarbell JM et al. | Mechanosensing at the vascular interface. | 2014 | Annu Rev Biomed Eng | pmid:24905872 |
Mahajan-Thakur S et al. | Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. | 2014 | J. Leukoc. Biol. | pmid:24990321 |
Kondo S et al. | Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. | 2014 | PLoS ONE | pmid:24714781 |
Korbelik M et al. | Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. | 2014 | Int. Immunopharmacol. | pmid:24713544 |
Gatfield J et al. | Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. | 2014 | Cell. Signal. | pmid:24704119 |
Shin KO et al. | Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. | 2014 | Arch. Pharm. Res. | pmid:24687256 |
Yu H et al. | Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. | 2014 | Injury | pmid:24685054 |
Smyth SS et al. | Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24482375 |
Sykes DA et al. | Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization. | 2014 | Br. J. Pharmacol. | pmid:24641481 |
Zhang J and Song J | Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. | 2014 | Acta Biomater | pmid:24631657 |
Priceman SJ et al. | S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. | 2014 | Cell Rep | pmid:24630990 |
Oizumi A et al. | Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. | 2014 | PLoS ONE | pmid:24586752 |
Guan Z et al. | Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature. | 2014 | J. Am. Soc. Nephrol. | pmid:24578134 |
Borge M et al. | The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. | 2014 | J. Immunol. | pmid:25127862 |
Blaho VA and Hla T | An update on the biology of sphingosine 1-phosphate receptors. | 2014 | J. Lipid Res. | pmid:24459205 |
Mendes-Braz M et al. | The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. | 2014 | Liver Int. | pmid:24107124 |
Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
Egom EE | Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. | 2014 | J Cardiovasc Med (Hagerstown) | pmid:23839592 |
Jensen T et al. | The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25442311 |
Fincher J et al. | G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. | 2014 | Dev. Neurosci. | pmid:25138637 |
Cencetti F et al. | Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis. | 2014 | FEBS J. | pmid:25131845 |
Neuber C et al. | Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. | 2014 | Anal. Chem. | pmid:25137547 |
Speak AO et al. | Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. | 2014 | Blood | pmid:24235134 |
Nagahashi M et al. | Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24210073 |
Ratajczak MZ et al. | The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. | 2014 | Expert Opin. Ther. Targets | pmid:24188167 |
Chawla S et al. | Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. | 2014 | Lipids | pmid:24190514 |