Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pyne NJ et al. | Sphingosine 1-phosphate signalling in cancer. | 2012 | Biochem. Soc. Trans. | pmid:22260672 |
Jin YX et al. | A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | 2012 | Bioresour. Technol. | pmid:22940331 |
Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
Moon MH et al. | Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | 2012 | Int. J. Mol. Med. | pmid:22992945 |
Park TS and Goldberg IJ | Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure. | 2012 | Heart Fail Clin | pmid:22999245 |
Ihlefeld K et al. | Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2012 | Biochem. J. | pmid:22908849 |
Wang ZY et al. | [Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22931670 |
Miller E et al. | Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. | 2012 | Chem. Biol. | pmid:22884261 |
Cannon RE et al. | Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22949658 |
Richerioux N et al. | Rho-ROCK and Rac-PAK signaling pathways have opposing effects on the cell-to-cell spread of Marek's Disease Virus. | 2012 | PLoS ONE | pmid:22952878 |
He S et al. | Self-amplification mechanisms of mast cell activation: a new look in allergy. | 2012 | Curr. Mol. Med. | pmid:22920722 |
Hisano Y et al. | The functional roles of S1P in immunity. | 2012 | J. Biochem. | pmid:22923732 |
Calise S et al. | Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. | 2012 | Biochim. Biophys. Acta | pmid:22178384 |
Balczerski B et al. | Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. | 2012 | Dev. Biol. | pmid:22185793 |
Witt W et al. | Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves. | 2012 | Cardiovasc. Res. | pmid:22232739 |
Madhunapantula SV et al. | Targeting sphingosine kinase-1 to inhibit melanoma. | 2012 | Pigment Cell Melanoma Res | pmid:22236408 |
Che W et al. | Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. | 2012 | Biochim. Biophys. Acta | pmid:22743041 |
Testai FD et al. | Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage. | 2012 | Stroke | pmid:22713492 |
GarcÃa-Merino JA and Sánchez AJ | [Basic mechanisms of action of fingolimod in relation to multiple sclerosis]. | 2012 | Rev Neurol | pmid:22718407 |
Hisano Y et al. | Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | 2012 | PLoS ONE | pmid:22723910 |
Chiba K and Yoshii N | [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. | 2012 | Nippon Yakurigaku Zasshi | pmid:22728990 |
Linke B et al. | Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22732087 |
Yokoyama K et al. | Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. | 2012 | Clin. Nephrol. | pmid:22732343 |
Czarnota GJ et al. | Tumor radiation response enhancement by acoustical stimulation of the vasculature. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22778441 |
Boussommier-Calleja A et al. | Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22807298 |
Kharel Y et al. | Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. | 2012 | Biochem. J. | pmid:22747486 |
Park SW et al. | Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. | 2012 | J. Am. Soc. Nephrol. | pmid:22095950 |
Liu X et al. | Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. | 2012 | Mol. Cell. Biochem. | pmid:22113622 |
Liu X et al. | ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate. | 2012 | Clin. Chim. Acta | pmid:22115863 |
Juarez JG et al. | Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. | 2012 | Blood | pmid:22049516 |
Pennington LD et al. | Quinolinone-based agonists of S1Pâ‚: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22104144 |
Milara J et al. | Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. | 2012 | Thorax | pmid:22106015 |
Raje MR et al. | Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. | 2012 | Bioorg. Med. Chem. | pmid:22137932 |
Peng P et al. | [Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor]. | 2012 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22445989 |
Podbielska M et al. | Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. | 2012 | Neurochem. Res. | pmid:22451227 |
Altay O et al. | Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. | 2012 | Crit. Care Med. | pmid:22488000 |
Tian YL et al. | [Research progress of the selective sphingosine-1-phosphate receptor 1 agonists]. | 2012 | Yao Xue Xue Bao | pmid:22493799 |
Makino Y et al. | Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle. | 2012 | Allergol Int | pmid:22441633 |
Spiegel S et al. | Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. | 2012 | Oncogene | pmid:21725353 |
Krishna SM et al. | Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | 2012 | Am. J. Pathol. | pmid:22698985 |
Lee SH et al. | Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22679064 |
Kim CH et al. | Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. | 2012 | Leukemia | pmid:21769103 |
Ponnusamy S et al. | Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. | 2012 | EMBO Mol Med | pmid:22707406 |
Kunisawa J and Kiyono H | Immunological function of sphingosine 1-phosphate in the intestine. | 2012 | Nutrients | pmid:22666543 |
Yang J et al. | Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling. | 2012 | Circulation | pmid:22668972 |
Li C et al. | Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. | 2012 | J. Neurophysiol. | pmid:22673325 |
Obinata H and Hla T | Sphingosine 1-phosphate in coagulation and inflammation. | 2012 | Semin Immunopathol | pmid:21805322 |
Watson L et al. | Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus. | 2012 | J. Clin. Immunol. | pmid:22648459 |
Sato C et al. | Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22659743 |
Tencé M et al. | Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists. | 2012 | Cell. Signal. | pmid:21872657 |
Farahat WA et al. | Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. | 2012 | PLoS ONE | pmid:22662145 |
Lucki NC and Sewer MB | Nuclear sphingolipid metabolism. | 2012 | Annu. Rev. Physiol. | pmid:21888508 |
Duru EA et al. | SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration. | 2012 | J. Surg. Res. | pmid:21920544 |
Yang F et al. | Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. | 2012 | Cancer Biol. Ther. | pmid:22406995 |
Kwak HI et al. | Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. | 2012 | Angiogenesis | pmid:22407449 |
Singh AT et al. | Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization. | 2012 | Reprod. Biomed. Online | pmid:22197131 |
Pitman MR et al. | Molecular targets of FTY720 (fingolimod). | 2012 | Curr. Mol. Med. | pmid:22834825 |
Curry FE et al. | Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22865384 |
Masuko K et al. | Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis. | 2012 | Int J Rheum Dis | pmid:22898216 |
Schmitz EI et al. | Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃. | 2012 | Mol. Cell. Biochem. | pmid:22899173 |
Egom EE | A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | 2012 | Ther Adv Cardiovasc Dis | pmid:22902834 |
Liu Q et al. | Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | 2012 | PLoS ONE | pmid:22848628 |
Asghar MY et al. | Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells. | 2012 | Endocr. Relat. Cancer | pmid:22889737 |
Kim BJ et al. | Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22879631 |
Knapp M et al. | Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | 2012 | Lipids | pmid:22833182 |
Beckham TH et al. | Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. | 2012 | Int. J. Cancer | pmid:22322590 |
Brizuela L et al. | First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. | 2012 | Mol. Cancer Ther. | pmid:22784711 |
Babahosseini H et al. | Roles of bioactive sphingolipid metabolites in ovarian cancer cell biomechanics. | 2012 | Conf Proc IEEE Eng Med Biol Soc | pmid:23366417 |
Salata D et al. | [Sphingosine-1-phosphate--molecular maestro]. | 2012 | Postepy Biochem. | pmid:23373414 |
Japtok L et al. | Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. | 2012 | PLoS ONE | pmid:23145172 |
Zhang L et al. | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. | 2012 | J. Exp. Med. | pmid:23148237 |
Qiao Y et al. | Sphingosine 1-phosphate elicits proinflammatory responses in ARPE-19 cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:23150617 |
Mendoza A et al. | The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. | 2012 | Cell Rep | pmid:23103166 |
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Bhattacharya M et al. | IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22561460 |
Spohr TC et al. | Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells. | 2012 | J. Neurosci. Res. | pmid:22588662 |
Parrill AL et al. | Structure of the first sphingosine 1-phosphate receptor. | 2012 | Sci Signal | pmid:22623751 |
Trifilieff A and Fozard JR | Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22570366 |
Van Brocklyn JR and Williams JB | The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. | 2012 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:22613819 |
Loh KC et al. | Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. | 2012 | PLoS ONE | pmid:22606352 |
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Brizuela L and Cuvillier O | Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate. | 2012 | Methods Mol. Biol. | pmid:22528435 |
Kawashima T et al. | Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:23041148 |
Pitman MR et al. | Isoform-selective assays for sphingosine kinase activity. | 2012 | Methods Mol. Biol. | pmid:22528436 |
Bode C and Gräler MH | Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry. | 2012 | Methods Mol. Biol. | pmid:22528437 |
Sorci-Thomas MG and Thomas MJ | High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:23077142 |
Yonesu K and Nara F | [Anti-angiogenic effect of bioactive lipid antagonists]. | 2012 | Nippon Rinsho | pmid:23513926 |
Mann DL | Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. | 2012 | Circulation | pmid:22534620 |
Meissner A et al. | Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. | 2012 | Circulation | pmid:22534621 |
Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
Maceyka M et al. | Sphingosine-1-phosphate signaling and its role in disease. | 2012 | Trends Cell Biol. | pmid:22001186 |
Knapp M et al. | Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | 2012 | Basic Res. Cardiol. | pmid:22961594 |
Gupta VK et al. | Focus on molecules: Sphingosine 1 Phosphate (S1P). | 2012 | Exp. Eye Res. | pmid:22001715 |
Morel S et al. | The natural cardioprotective particle HDL modulates connexin43 gap junction channels. | 2012 | Cardiovasc. Res. | pmid:21960685 |
Su G et al. | Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:21980034 |
Castillo-Badillo JA et al. | Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions. | 2012 | Biochim. Biophys. Acta | pmid:22019450 |
Nagahashi M et al. | Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | 2012 | Cancer Res. | pmid:22298596 |
Ratajczak J et al. | A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. | 2012 | Leukemia | pmid:22343521 |
Mascall KS et al. | Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. | 2012 | J. Cell. Sci. | pmid:22344262 |
Hsu A et al. | Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells. | 2012 | Int. J. Oncol. | pmid:22344462 |