Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Buehrer BM and Bell RM | Sphingosine kinase: properties and cellular functions. | 1993 | Adv. Lipid Res. | pmid:8397478 |
Olivera A and Spiegel S | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. | 1993 | Nature | pmid:8413613 |
Fatatis A and Miller RJ | Sphingosine and sphingosine 1-phosphate differentially modulate platelet-derived growth factor-BB-induced Ca2+ signaling in transformed oligodendrocytes. | 1996 | J. Biol. Chem. | pmid:8550576 |
Yatomi Y et al. | N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. | 1996 | Biochemistry | pmid:8555236 |
van Koppen C et al. | Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. | 1996 | J. Biol. Chem. | pmid:8567663 |
Spiegel S and Milstien S | Sphingolipid metabolites: members of a new class of lipid second messengers. | 1995 | J. Membr. Biol. | pmid:8568838 |
Choi OH et al. | Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. | 1996 | Nature | pmid:8602265 |
Okajima F et al. | Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells. | 1996 | FEBS Lett. | pmid:8603702 |
Yamamura S et al. | Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. | 1996 | FEBS Lett. | pmid:8612751 |
Pyne S et al. | Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. | 1996 | Eur. J. Biochem. | pmid:8647130 |
Van Koppen CJ et al. | A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. | 1996 | Mol. Pharmacol. | pmid:8649355 |
Cuvillier O et al. | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. | 1996 | Nature | pmid:8657285 |
Waggoner DW et al. | Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. | 1996 | J. Biol. Chem. | pmid:8663293 |
Postma FR et al. | Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. | 1996 | EMBO J. | pmid:8665846 |
Bünemann M et al. | Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate. | 1995 | J. Physiol. (Lond.) | pmid:8788935 |
Berger A et al. | Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. | 1996 | Mol. Pharmacol. | pmid:8794881 |
Hashizume T et al. | Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets. | 1996 | J. Biochem. | pmid:8864845 |
Bünemann M et al. | A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. | 1996 | EMBO J. | pmid:8896446 |
Meyer zu Heringdrof D et al. | Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8897440 |
Spiegel S and Merrill AH | Sphingolipid metabolism and cell growth regulation. | 1996 | FASEB J. | pmid:8903509 |
Hung WC and Chuang LY | Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954076 |
Yang L et al. | Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954916 |
Okajima F et al. | Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. | 1997 | Endocrinology | pmid:8977407 |
Chung T et al. | ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. | 1997 | J. Biol. Chem. | pmid:9006957 |
Mano N et al. | Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. | 1997 | Anal. Biochem. | pmid:9025946 |
Yatomi Y et al. | Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. | 1997 | J. Biol. Chem. | pmid:9030602 |
Rani CS et al. | Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. | 1997 | J. Biol. Chem. | pmid:9099730 |
Yatomi Y et al. | Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues. | 1997 | FEBS Lett. | pmid:9119058 |
Törnquist K | Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. | 1997 | Am. J. Physiol. | pmid:9124507 |
Shirahama T et al. | Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. | 1997 | FEBS Lett. | pmid:9141489 |
Shatrov VA et al. | Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9168973 |
Im DS et al. | Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes. | 1997 | Am. J. Physiol. | pmid:9176218 |
Yamada T et al. | Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions. | 1997 | Cell. Mol. Life Sci. | pmid:9176562 |
Wang F et al. | Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. | 1997 | Biochem. J. | pmid:9182707 |
Yatomi Y et al. | Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. | 1997 | J. Biochem. | pmid:9192741 |
Blakesley VA et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. | 1997 | J. Biol. Chem. | pmid:9195921 |
Kiss Z and Mukherjee JJ | Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism. | 1997 | FEBS Lett. | pmid:9257719 |
Yamamura S et al. | Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. | 1997 | Biochemistry | pmid:9271506 |
Edsall LC et al. | Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. | 1997 | J. Neurosci. | pmid:9278531 |
Orlati S et al. | Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. | 1997 | Biochim. Biophys. Acta | pmid:9296526 |
Kozawa O et al. | Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. | 1997 | J. Biol. Chem. | pmid:9312119 |
Törnquist K et al. | Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells. | 1997 | Endocrinology | pmid:9322911 |
Saba JD et al. | The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. | 1997 | J. Biol. Chem. | pmid:9334171 |
Kiss Z et al. | Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine. | 1997 | Biochem. J. | pmid:9371692 |
Sato K et al. | Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9388477 |
Kozawa O et al. | Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts. | 1997 | FEBS Lett. | pmid:9414115 |
Mandala SM et al. | Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9419344 |
Cuvillier O et al. | Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. | 1998 | J. Biol. Chem. | pmid:9446602 |
Conway AM et al. | Sphingosine 1-phosphate activation of MAP kinase--involvement of PI 3-kinase and protein kinase C. | 1997 | Biochem. Soc. Trans. | pmid:9450013 |
Kawa S et al. | Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate. | 1997 | FEBS Lett. | pmid:9459309 |
Zondag GC et al. | Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. | 1998 | Biochem. J. | pmid:9480864 |
Lee MJ et al. | Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. | 1998 | Science | pmid:9488656 |
Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
Igarashi Y | Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways. | 1997 | J. Biochem. | pmid:9498549 |
Crilly KS et al. | The choline kinase inhibitor hemicholinium-3 can inhibit mitogen-induced DNA synthesis independent of its effect on phosphocholine formation. | 1998 | Arch. Biochem. Biophys. | pmid:9521826 |
Spiegel S et al. | Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. | 1998 | Biochemistry Mosc. | pmid:9526097 |
Hamada K et al. | Involvement of Mac-1-mediated adherence and sphingosine 1-phosphate in survival of phorbol ester-treated U937 cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9535736 |
Hisano N et al. | Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine. | 1998 | J. Biochem. | pmid:9538201 |
Melendez A et al. | FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. | 1998 | J. Biol. Chem. | pmid:9545263 |
Igarashi Y et al. | Inhibition of mouse B16 melanoma cell motility by sphingosine-1-phosphate. | 1997 | Adv. Exp. Med. Biol. | pmid:9547620 |
Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
Himmel HM et al. | Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells. | 1998 | Mol. Pharmacol. | pmid:9584212 |
Tas PW and Koschel K | Sphingosine-1-phosphate induces a Ca2+ signal in primary rat astrocytes and a Ca2+ signal and shape changes in C6 rat glioma cells. | 1998 | J. Neurosci. Res. | pmid:9589387 |
Lanterman MM and Saba JD | Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. | 1998 | Biochem. J. | pmid:9601083 |
Nakamura H et al. | Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. | 1998 | J. Biol. Chem. | pmid:9624115 |
Noh SJ et al. | Different signaling pathway between sphingosine-1-phosphate and lysophosphatidic acid in Xenopus oocytes: functional coupling of the sphingosine-1-phosphate receptor to PLC-xbeta in Xenopus oocytes. | 1998 | J. Cell. Physiol. | pmid:9648929 |
Van Brocklyn JR et al. | Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. | 1998 | J. Cell Biol. | pmid:9660876 |
Spiegel S et al. | Sphingosine-1-phosphate in cell growth and cell death. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668339 |
Igarashi Y | Sphingosine-1-phosphate as an intercellular signaling molecule. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668340 |
Stam JC et al. | Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. | 1998 | EMBO J. | pmid:9670021 |
Nagiec MM et al. | The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. | 1998 | J. Biol. Chem. | pmid:9677363 |
van Echten-Deckert G et al. | Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. | 1998 | J. Biol. Chem. | pmid:9722598 |
Edsall LC et al. | N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. | 1998 | Biochemistry | pmid:9737868 |
Kovács P et al. | The effects of ceramide and its analogues on the secretion of the mucocyst content of Tetrahymena. | 1998 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:9763202 |
Okamoto H et al. | EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. | 1998 | J. Biol. Chem. | pmid:9765227 |
Vasta V et al. | Effects of sphingosine 1-phosphate and bradykinin on phospholipid signalling in human epithelial A549 cells. | 1998 | Biochem. Soc. Trans. | pmid:9765948 |
Hida H et al. | Ceramide inhibits inwardly rectifying K+ currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes. | 1998 | J. Neurosci. | pmid:9786978 |
Igarashi Y and Yatomi Y | Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles. | 1998 | Acta Biochim. Pol. | pmid:9821862 |
Guo C et al. | Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate. | 1998 | Eur. J. Biochem. | pmid:9826186 |
Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
Goetzl EJ and An S | Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. | 1998 | FASEB J. | pmid:9837849 |
MacDonell KL et al. | Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes. | 1998 | Am. J. Physiol. | pmid:9843831 |
Chen PF et al. | Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells. | 1998 | Kidney Int. | pmid:9844123 |
Li S et al. | Chemical synthesis of D-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes. | 1999 | J. Lipid Res. | pmid:9869657 |
Qiao L et al. | Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871527 |
Sato K et al. | Downregulation of mRNA expression of Edg-3, a putative sphingosine 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9878524 |
Sato K et al. | Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. | 1999 | Mol. Pharmacol. | pmid:9882706 |
Yatomi Y et al. | [Signal transduction related to sphingosine 1-phosphate]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9883680 |
Orlati S et al. | Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells. | 1998 | Cell Calcium | pmid:9924630 |
Sato K et al. | Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor. | 1999 | FEBS Lett. | pmid:9928946 |
Hung WC et al. | Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells. | 1999 | Biochem. J. | pmid:9931312 |
Zhang G et al. | Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. | 1999 | Gene | pmid:9931453 |
Alemany R et al. | Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:9933590 |
Goetzl EJ et al. | Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. | 1999 | J. Immunol. | pmid:9973477 |
Van Brocklyn JR et al. | Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. | 1999 | J. Biol. Chem. | pmid:9988698 |