Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
Yanagida K et al. | Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28396408 |
Park K et al. | ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26903652 |
Browne CD et al. | SHEP1 partners with CasL to promote marginal zone B-cell maturation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20956287 |
Mandala SM et al. | Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9419344 |
Bouma HR et al. | Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21245336 |
Sadahira Y et al. | Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1409683 |
Wojciak JM et al. | The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19815502 |
Ledent C et al. | Premature ovarian aging in mice deficient for Gpr3. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15956199 |
Christoffersen C et al. | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21606363 |
Kikuta J et al. | Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569273 |
Nguyen DH et al. | Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569284 |
Roviezzo F et al. | Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15254297 |
Matsushita K et al. | Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273282 |
Egom EE et al. | Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling. | 2010 | Prog. Biophys. Mol. Biol. | pmid:20080123 |
Nadal A et al. | Glial cell responses to lipids bound to albumin in serum and plasma. | 2001 | Prog. Brain Res. | pmid:11545003 |
Gomez-Muñoz A et al. | Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. | 2016 | Prog. Lipid Res. | pmid:26703189 |
Pyne NJ and Tigyi GJ | A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. | 2016 | Prog. Lipid Res. | pmid:26584871 |
Watterson K et al. | Pleiotropic actions of sphingosine-1-phosphate. | 2003 | Prog. Lipid Res. | pmid:12790117 |
Gangoiti P et al. | Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. | 2010 | Prog. Lipid Res. | pmid:20193711 |