Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oshima Y et al. | Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization. | 2004 | J. Cell. Physiol. | pmid:15095287 |
| Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
| Lim HS et al. | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109640 |
| Cui J et al. | Role of ceramide in ischemic preconditioning. | 2004 | J. Am. Coll. Surg. | pmid:15110811 |
| Jolly PS et al. | Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. | 2004 | J. Exp. Med. | pmid:15067032 |
| Kang YC et al. | Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | 2004 | Cell Death Differ. | pmid:15297884 |
| Anliker B and Chun J | Cell surface receptors in lysophospholipid signaling. | 2004 | Semin. Cell Dev. Biol. | pmid:15271291 |
| Pyne S et al. | Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. | 2004 | Semin. Cell Dev. Biol. | pmid:15271294 |
| Tokumura A | Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators. | 2004 | J. Cell. Biochem. | pmid:15258912 |
| Muehlich S et al. | Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | 2004 | Atherosclerosis | pmid:15262182 |
| Sun C and Bittman R | An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters. | 2004 | J. Org. Chem. | pmid:15497998 |
| Wang FX et al. | mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15498114 |
| Nakamura H et al. | Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death. | 2004 | Biochem. Pharmacol. | pmid:15498509 |
| Billich A and Ettmayer P | Fluorescence-based assay of sphingosine kinases. | 2004 | Anal. Biochem. | pmid:14769343 |
| Amano S et al. | Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. | 2004 | Br. J. Dermatol. | pmid:15541073 |
| Baudhuin LM et al. | S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). | 2004 | FASEB J. | pmid:14657000 |
| Otala M et al. | Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate. | 2004 | Biol. Reprod. | pmid:14613902 |
| Kelley GG et al. | Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. | 2004 | Biochem. J. | pmid:14567755 |
| Oskouian B and Saba JD | Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271298 |
| Matsushita K et al. | Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273282 |
| Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | 2004 | Circulation | pmid:15277330 |
| Chavakis T et al. | Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. | 2004 | FASEB J. | pmid:15208269 |
| Xu CB et al. | Sphingosine signaling and atherogenesis. | 2004 | Acta Pharmacol. Sin. | pmid:15210056 |
| Deretic D et al. | Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors. | 2004 | Mol. Biol. Cell | pmid:13679519 |
| Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
| Stahelin RV et al. | The mechanism of membrane targeting of human sphingosine kinase 1. | 2005 | J. Biol. Chem. | pmid:16243846 |
| Cyster JG | Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. | 2005 | Annu. Rev. Immunol. | pmid:15771568 |
| Church LD et al. | TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx. | 2005 | J. Leukoc. Biol. | pmid:15817701 |
| Tamama K et al. | High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | 2005 | Atherosclerosis | pmid:15585196 |
| Zhang B et al. | Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | 2005 | Atherosclerosis | pmid:15585219 |
| Hojjati MR et al. | Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. | 2005 | J. Biol. Chem. | pmid:15590644 |
| Davis MD et al. | Sphingosine 1-phosphate analogs as receptor antagonists. | 2005 | J. Biol. Chem. | pmid:15590668 |
| Kihara A et al. | [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16146193 |
| Fieger CB et al. | Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | 2005 | FASEB J. | pmid:16148028 |
| Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
| Schwab SR et al. | Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | 2005 | Science | pmid:16151014 |
| Butter JJ et al. | A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16023899 |
| Maguire JJ and Davenport AP | Regulation of vascular reactivity by established and emerging GPCRs. | 2005 | Trends Pharmacol. Sci. | pmid:16054240 |
| Yopp AC et al. | Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | 2005 | J. Immunol. | pmid:16116177 |
| Czeloth N et al. | Sphingosine-1-phosphate mediates migration of mature dendritic cells. | 2005 | J. Immunol. | pmid:16116182 |
| Bandhuvula P et al. | The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | 2005 | J. Biol. Chem. | pmid:16118221 |
| Kharel Y et al. | Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | 2005 | J. Biol. Chem. | pmid:16093248 |
| Maceyka M et al. | Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099387 |
| Rosen H | Chemical approaches to the lysophospholipid receptors. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099402 |
| Petrache I et al. | Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. | 2005 | Nat. Med. | pmid:15852018 |
| Mastrandrea LD et al. | Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. | 2005 | Diabetes | pmid:15855330 |
| Kim KS et al. | GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. | 2005 | FASEB J. | pmid:15857892 |
| Pettus BJ et al. | The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. | 2005 | Mol. Pharmacol. | pmid:15900018 |
| Katsuma S et al. | Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. | 2005 | FEBS Lett. | pmid:15862293 |
| Johnstone ED et al. | Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. | 2005 | J. Lipid Res. | pmid:15995175 |