Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Price MM et al. | A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:22939756 |
Garris CS et al. | Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. | 2013 | Nat. Immunol. | pmid:24076635 |
Koch A et al. | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. | 2013 | Biochim. Biophys. Acta | pmid:23906789 |
Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
Donati C et al. | New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology. | 2013 | Biochim. Biophys. Acta | pmid:22877992 |
Kotani T et al. | Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. | 2013 | Biol. Reprod. | pmid:23863409 |
Zhao CG et al. | Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. | 2013 | Physiol Res | pmid:23869887 |
Knapp M et al. | Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:24120760 |
Yuan S et al. | Lipid receptor S1Pâ‚ activation scheme concluded from microsecond all-atom molecular dynamics simulations. | 2013 | PLoS Comput. Biol. | pmid:24098103 |
Bot M et al. | Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. | 2013 | PLoS ONE | pmid:23700419 |
Arce FT et al. | Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. | 2013 | Nanomedicine | pmid:23523769 |
Herr DR et al. | Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. | 2013 | J. Biol. Chem. | pmid:24003216 |
Dave JM et al. | Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). | 2013 | J. Biol. Chem. | pmid:24005669 |
Deng H et al. | Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. | 2013 | ACS Med Chem Lett | pmid:24900589 |
Zhang W et al. | Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23770055 |
Southern C et al. | Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. | 2013 | J Biomol Screen | pmid:23396314 |
Brewer JW | Phospholipids: "greasing the wheels" of humoral immunity. | 2013 | Biochim. Biophys. Acta | pmid:23051607 |
Ishii M and Kikuta J | Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. | 2013 | Biochim. Biophys. Acta | pmid:22691949 |
Mierzejewska K et al. | Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow. | 2013 | Biomed Res Int | pmid:24490172 |
Ley S et al. | The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. | 2013 | Oncogene | pmid:22410777 |
Beckham TH et al. | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. | 2013 | PLoS ONE | pmid:24098536 |
Xiong Y et al. | Sphingosine kinases are not required for inflammatory responses in macrophages. | 2013 | J. Biol. Chem. | pmid:24081141 |
Zhang W et al. | ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. | 2013 | J. Biol. Chem. | pmid:24064218 |
Babahosseini H et al. | Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. | 2013 | Integr Biol (Camb) | pmid:24056950 |
Zhang O et al. | Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. | 2013 | Mol. Microbiol. | pmid:23980754 |
Olivera A et al. | Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. | 2013 | J. Leukoc. Biol. | pmid:23904439 |
Sun X et al. | Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23911438 |
Karimian G et al. | Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis. | 2013 | Biochim. Biophys. Acta | pmid:23816565 |
Liu Y et al. | Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. | 2013 | J. Pathol. | pmid:23839903 |
Riccitelli E et al. | Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. | 2013 | PLoS ONE | pmid:23826381 |
Wang Y et al. | Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. | 2013 | Endocrinology | pmid:23787120 |
Wang Z et al. | Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. | 2013 | Structure | pmid:23602659 |
Salmanzadeh A et al. | Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. | 2013 | Integr Biol (Camb) | pmid:23609351 |
Orr Gandy KA et al. | Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. | 2013 | FASEB J. | pmid:23629860 |
Schneider G et al. | Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. | 2013 | Mol. Cancer Res. | pmid:23615526 |
Cinq-Frais C et al. | A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. | 2013 | Biochim. Biophys. Acta | pmid:23651497 |
Christoffersen C and Nielsen LB | Apolipoprotein M: bridging HDL and endothelial function. | 2013 | Curr. Opin. Lipidol. | pmid:23652568 |
Egom EE et al. | HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL. | 2013 | Curr. Opin. Lipidol. | pmid:23652570 |
Lundblad C et al. | Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. | 2013 | Acta Anaesthesiol Scand | pmid:23683126 |
CamprubÃ-Robles M et al. | Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. | 2013 | J. Neurosci. | pmid:23392686 |
Yasuo M et al. | Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. | 2013 | PLoS ONE | pmid:23326540 |
Kim YD et al. | Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23307289 |
Sharma N et al. | Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. | 2013 | J. Leukoc. Biol. | pmid:23345392 |
Salvemini D et al. | Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. | 2013 | Trends Pharmacol. Sci. | pmid:23318139 |
Tibolla G et al. | Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. | 2013 | PLoS ONE | pmid:23320105 |
Lee YJ et al. | Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. | 2013 | Int. J. Mol. Med. | pmid:23381659 |
Yangyuoru PM et al. | Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. | 2013 | Methods Mol. Biol. | pmid:23386355 |
Dillahunt SE et al. | Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. | 2013 | J. Immunol. | pmid:23359503 |
Tong X et al. | High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. | 2013 | Cardiovasc Diabetol | pmid:23360427 |
Finley A et al. | Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. | 2013 | PLoS ONE | pmid:23372844 |
Véret J et al. | Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival. | 2013 | Biochim. Biophys. Acta | pmid:23085009 |
Di Menna L et al. | Fingolimod protects cultured cortical neurons against excitotoxic death. | 2013 | Pharmacol. Res. | pmid:23073075 |
Zu Heringdorf DM et al. | Pharmacology of the sphingosine-1-phosphate signalling system. | 2013 | Handb Exp Pharmacol | pmid:23579459 |
Matheu MP et al. | Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. | 2013 | PLoS ONE | pmid:23533579 |
Sobel K et al. | Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. | 2013 | J. Biol. Chem. | pmid:23589284 |
Barth BM et al. | Gaucher's disease and cancer: a sphingolipid perspective. | 2013 | Crit Rev Oncog | pmid:23510065 |
Bernhart E et al. | Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. | 2013 | Exp. Cell Res. | pmid:23562655 |
Pyne NJ et al. | Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. | 2013 | Biochim. Biophys. Acta | pmid:22801038 |
Koch A et al. | Sphingosine 1-phosphate in renal diseases. | 2013 | Cell. Physiol. Biochem. | pmid:23736205 |
Huang LS et al. | Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. | 2013 | FASEB J. | pmid:23315259 |
Fukuhara S and Mochizuki N | [Lymphocytes mobilization into blood regulated by Spns2, a sphingosine 1-phosphate transporter, expressed on endothelial cells]. | 2013 | Seikagaku | pmid:23717873 |
O'Sullivan C and Dev KK | The structure and function of the S1P1 receptor. | 2013 | Trends Pharmacol. Sci. | pmid:23763867 |
Chang CH et al. | Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. | 2013 | Acta Pharmacol. Sin. | pmid:23377549 |
Cuvillier O et al. | Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. | 2013 | Adv. Cancer Res. | pmid:23290779 |
Alshaker H et al. | Therapeutic potential of targeting SK1 in human cancers. | 2013 | Adv. Cancer Res. | pmid:23290780 |
Heffernan-Stroud LA and Obeid LM | Sphingosine kinase 1 in cancer. | 2013 | Adv. Cancer Res. | pmid:23290781 |
Zhang J et al. | Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. | 2013 | Hum. Reprod. | pmid:24001716 |
Kihara A | [Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. | 2013 | Seikagaku | pmid:23980469 |
Weichand B et al. | Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. | 2013 | Eur. J. Immunol. | pmid:23934754 |
Morad SA et al. | Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. | 2013 | Biochim. Biophys. Acta | pmid:23939396 |
Morozov VI et al. | Sphingosine-1-phosphate: distribution, metabolism and role in the regulation of cellular functions. | 2013 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:23534286 |
Ratajczak MZ et al. | An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22981511 |
Lee H et al. | 4-Deoxypyridoxine improves the viability of isolated pancreatic islets ex vivo. | 2013 May-Jun | Islets | pmid:23756681 |
Egom EE et al. | Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy. | 2013 May-Jun | Crit Rev Clin Lab Sci | pmid:23885725 |
Yu Y et al. | Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. | 2014 | Lipids | pmid:24158769 |
Giannouli CC et al. | Visualizing S1P-directed cellular egress by intravital imaging. | 2014 | Biochim. Biophys. Acta | pmid:24090699 |
Brünnert D et al. | Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. | 2014 | Mol. Hum. Reprod. | pmid:24994816 |
Ohotski J et al. | Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. | 2014 | Cell. Signal. | pmid:24486401 |
Gomes L et al. | Sphingosine 1-phosphate in acute dengue infection. | 2014 | PLoS ONE | pmid:25409037 |
Xu M et al. | FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. | 2014 | Acta Pharmacol. Sin. | pmid:25399649 |
Bigaud M et al. | Second generation S1P pathway modulators: research strategies and clinical developments. | 2014 | Biochim. Biophys. Acta | pmid:24239768 |
Huang YL et al. | Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. | 2014 | Cell. Signal. | pmid:24333325 |
Emery SM et al. | Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24259678 |
Adamson RH et al. | Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24531813 |
Rosen H et al. | The organization of the sphingosine 1-phosphate signaling system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728591 |
Goñi FM et al. | Biophysical properties of sphingosine, ceramides and other simple sphingolipids. | 2014 | Biochem. Soc. Trans. | pmid:25233422 |
Yagoub D et al. | Sphingosine kinase 1 isoform-specific interactions in breast cancer. | 2014 | Mol. Endocrinol. | pmid:25216046 |
Yang W et al. | Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. | 2014 | PLoS ONE | pmid:25188412 |
Chen J et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25180446 |
Kim EY et al. | Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. | 2014 | FASEB J. | pmid:25002116 |
Hao J et al. | The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. | 2014 | Arthritis Res. Ther. | pmid:25000985 |
Xiong Y and Hla T | S1P control of endothelial integrity. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728594 |
Jesko H et al. | Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. | 2014 | Folia Neuropathol | pmid:24729344 |
Zhu Y et al. | Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. | 2014 | Mol. Neurobiol. | pmid:24722820 |
Kondo S et al. | Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. | 2014 | PLoS ONE | pmid:24714781 |
Korbelik M et al. | Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. | 2014 | Int. Immunopharmacol. | pmid:24713544 |
Whisler JA et al. | Control of perfusable microvascular network morphology using a multiculture microfluidic system. | 2014 | Tissue Eng Part C Methods | pmid:24151838 |
Mendes-Braz M et al. | The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. | 2014 | Liver Int. | pmid:24107124 |
Zeng Y et al. | Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24285115 |
Speak AO et al. | Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. | 2014 | Blood | pmid:24235134 |