Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Japtok L et al. | Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. | 2015 | FASEB J. | pmid:25911610 |
Stone ML et al. | Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25910934 |
Urtz N et al. | Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. | 2015 | Circ. Res. | pmid:26129975 |
Desai P et al. | Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis. | 2015 | Mol. Cell. Biochem. | pmid:26350564 |
Molinari G | Is hydrogen ion (H(+)) the real second messenger in calcium signalling? | 2015 | Cell. Signal. | pmid:25843778 |
Nussbaum C et al. | Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. | 2015 | Nat Commun | pmid:25832730 |
Riley RT et al. | A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. | 2015 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:25833119 |
Proia RL and Hla T | Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. | 2015 | J. Clin. Invest. | pmid:25831442 |
Lee SY et al. | Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. | 2015 | Hepatology | pmid:25808625 |
Salama MF et al. | A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. | 2015 | FASEB J. | pmid:25805832 |
Potì F et al. | SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. | 2015 | Atherosclerosis | pmid:25801013 |
Castillo-Badillo JA et al. | α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization. | 2015 | PLoS ONE | pmid:25799564 |
Brulhart-Meynet MC et al. | Improving reconstituted HDL composition for efficient post-ischemic reduction of ischemia reperfusion injury. | 2015 | PLoS ONE | pmid:25781943 |
Nojima H et al. | Sphingolipids in liver injury, repair and regeneration. | 2015 | Biol. Chem. | pmid:25781682 |
Newton J et al. | Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. | 2015 | Exp. Cell Res. | pmid:25770011 |
Muñoz-Sáez E et al. | Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). | 2015 | Neurosci. Lett. | pmid:25769802 |
Kang H et al. | The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension. | 2015 | Stem Cells Dev. | pmid:25761906 |
Carrera I et al. | A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease. | 2015 | Biomed Res Int | pmid:25759822 |
Ueda N | Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. | 2015 | Int J Mol Sci | pmid:25751724 |
Mikłosz A et al. | Hyperthyroidism evokes myocardial ceramide accumulation. | 2015 | Cell. Physiol. Biochem. | pmid:25613909 |
Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |
Chen LY et al. | The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells. | 2015 | Nat Commun | pmid:25591940 |
Zhang L et al. | Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. | 2015 | Clin. Cancer Res. | pmid:25589614 |
Chavez A et al. | S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. | 2015 | J. Cell. Sci. | pmid:25588843 |
O'Sullivan C and Dev KK | Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling. | 2015 | J. Cell. Sci. | pmid:26359302 |
Woszczek G and Fuerst E | Ca2+ mobilization assays in GPCR drug discovery. | 2015 | Methods Mol. Biol. | pmid:25563178 |
Li Q et al. | Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells. | 2015 | Exp. Physiol. | pmid:25557733 |
Borup A et al. | Apolipoprotein M in lipid metabolism and cardiometabolic diseases. | 2015 | Curr. Opin. Lipidol. | pmid:25551802 |
Montecucco F et al. | Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions. | 2015 | Handb Exp Pharmacol | pmid:25522998 |
Nofer JR | Signal transduction by HDL: agonists, receptors, and signaling cascades. | 2015 | Handb Exp Pharmacol | pmid:25522990 |
Baranowski M et al. | Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner. | 2015 | Eur. J. Appl. Physiol. | pmid:25519954 |
Oskeritzian CA et al. | The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. | 2015 | J. Allergy Clin. Immunol. | pmid:25512083 |
Kurano M et al. | LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate. | 2015 | J. Biol. Chem. | pmid:25505264 |
Santos WL and Lynch KR | Drugging sphingosine kinases. | 2015 | ACS Chem. Biol. | pmid:25384187 |
Prüfer N et al. | The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality. | 2015 | Biol. Chem. | pmid:25252751 |
Sorrentino R et al. | B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25250941 |
Klocke S et al. | Slow-freezing versus vitrification for human ovarian tissue cryopreservation. | 2015 | Arch. Gynecol. Obstet. | pmid:25115279 |
Wysoczynski M et al. | Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells. | 2015 | Stem Cell Rev | pmid:25086571 |
Czubowicz K et al. | Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival. | 2015 | Mol. Neurobiol. | pmid:25056275 |
Zhang T et al. | Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. | 2015 | Chem. Biol. Interact. | pmid:25557508 |
Burow P et al. | Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages. | 2015 | Pflugers Arch. | pmid:24965069 |
Pan HY et al. | Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis. | 2015 | Int Endod J | pmid:24931601 |
Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
Oskeritzian CA | Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. | 2015 | Mol. Immunol. | pmid:24766823 |
Kurek K et al. | Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. | 2015 | J Diabetes Res | pmid:26380311 |
Moon E et al. | Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. | 2015 | Mediators Inflamm. | pmid:26576074 |
Tang H et al. | Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits. | 2015 | Acta Cir Bras | pmid:26560422 |
Zhao C et al. | Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts. | 2015 | Mediators Inflamm. | pmid:26556954 |
Liu R et al. | Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line. | 2015 | J. Biol. Chem. | pmid:26518876 |
Wang Z et al. | Decreased Splenic CD4(+) T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. | 2015 | Biomed Res Int | pmid:26543853 |
Yu H et al. | Effect of sphingosine-1-phosphate and myoblast transplantation on rat acute myocardial infarction. | 2015 | Genet. Mol. Res. | pmid:26535699 |
Wang R et al. | Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration. | 2015 | J. Biol. Chem. | pmid:26534962 |
Fujii S | [Atherosclerosis, Chronic Inflammation, and Thrombosis: In Search of the Missing Link in Laboratory Medicine]. | 2015 | Rinsho Byori | pmid:26524900 |
Jones EE et al. | Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. | 2015 | Bioanalysis | pmid:26505686 |
Ramos-Perez WD et al. | A map of the distribution of sphingosine 1-phosphate in the spleen. | 2015 | Nat. Immunol. | pmid:26502404 |
Winkler MS et al. | Decreased serum concentrations of sphingosine-1-phosphate in sepsis. | 2015 | Crit Care | pmid:26498205 |
Matula K et al. | Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. | 2015 | BMC Cancer | pmid:26493335 |
Barnawi J et al. | Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). | 2015 | PLoS ONE | pmid:26485657 |
Deng Z et al. | Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. | 2015 | Nat Commun | pmid:25907800 |
Scanlon KM et al. | Novel therapies for the treatment of pertussis disease. | 2015 | Pathog Dis | pmid:26394802 |
Kihara Y et al. | Lysophospholipid receptors in drug discovery. | 2015 | Exp. Cell Res. | pmid:25499971 |
Kim ES et al. | A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. | 2015 | Chem. Biol. Interact. | pmid:25980589 |
Frej C et al. | Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation. | 2015 | Anal Bioanal Chem | pmid:26377937 |
Cheng Y et al. | Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. | 2015 | FASEB J. | pmid:25690654 |
Klyachkin YM et al. | Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction. | 2015 | Stem Cells Transl Med | pmid:26371341 |
Zeng Y et al. | Sphingosine 1-phosphate induced synthesis of glycocalyx on endothelial cells. | 2015 | Exp. Cell Res. | pmid:26364737 |
Choi S et al. | A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26361873 |
Flávia Nardy A et al. | Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease. | 2015 | Biomed Res Int | pmid:26347020 |
Dai L et al. | Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression. | 2015 | Oncotarget | pmid:26327294 |
Simón MV et al. | Sphingosine-1-Phosphate Is a Crucial Signal for Migration of Retina Müller Glial Cells. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26325420 |
Yang L et al. | Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice. | 2015 | Sci Rep | pmid:26324256 |
Hsu CK et al. | Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation. | 2015 | Br. J. Pharmacol. | pmid:26359950 |
Kharel Y et al. | Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26243740 |
Gao XY et al. | Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications. | 2015 | Oncol. Rep. | pmid:26239167 |
Adada MM et al. | Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. | 2015 | FASEB J. | pmid:26209696 |
Wang H et al. | Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate Receptor 3/Platelet-Derived Growth Factor Receptor-β. | 2015 | Cell. Mol. Biol. Lett. | pmid:26208383 |
Manes NP et al. | Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. | 2015 | Mol. Cell Proteomics | pmid:26199343 |
Spampinato SF et al. | Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? | 2015 | PLoS ONE | pmid:26197437 |
Airola MV et al. | Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. | 2015 | Structure | pmid:26190575 |
Vettorazzi S et al. | Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. | 2015 | Nat Commun | pmid:26183376 |
Michels M et al. | Decreased plasma levels of the endothelial protective sphingosine-1-phosphate are associated with dengue-induced plasma leakage. | 2015 | J. Infect. | pmid:26183296 |
Checa A et al. | Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment. | 2015 | Sci Rep | pmid:26174087 |
Schaffert SA et al. | mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. | 2015 | J. Immunol. | pmid:26163591 |
Gao Y et al. | Sphingosine kinase 1 as an anticancer therapeutic target. | 2015 | Drug Des Devel Ther | pmid:26150697 |
Denimal D et al. | Significant abnormalities of the HDL phosphosphingolipidome in type 1 diabetes despite normal HDL cholesterol concentration. | 2015 | Atherosclerosis | pmid:26142685 |
Yagi K et al. | Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. | 2015 | Stroke | pmid:26138121 |
Nakagawa Y and Chiba K | Diversity and plasticity of microglial cells in psychiatric and neurological disorders. | 2015 | Pharmacol. Ther. | pmid:26129625 |
Hyder CL et al. | Sphingolipids inhibit vimentin-dependent cell migration. | 2015 | J. Cell. Sci. | pmid:25908861 |
Schweitzer KS et al. | Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25979079 |
Lee KP et al. | DJ-1-mediated upregulation of serine palmitoyltransferase 2 controls vascular neointima via S1P autocrine. | 2015 | Int. J. Cardiol. | pmid:25978603 |
Morad SA and Cabot MC | Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications. | 2015 | Biochim. Biophys. Acta | pmid:25964209 |
Jing XD et al. | The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis. | 2015 | Clin. Chim. Acta | pmid:25958848 |
Laurenzana A et al. | Endothelial sphingosine kinase/SPNS2 axis is critical for vessel-like formation by human mesoangioblasts. | 2015 | J. Mol. Med. | pmid:25952146 |
Tian H and Yu Z | Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway. | 2015 | Int J Clin Exp Pathol | pmid:26045781 |
Rahman MM et al. | Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25951977 |
Prager B et al. | Sphingosine 1-phosphate signaling at the blood-brain barrier. | 2015 | Trends Mol Med | pmid:25939882 |
Rosenberg AJ et al. | A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands. | 2015 | Appl Radiat Isot | pmid:25931137 |
Trayssac M et al. | Role of Sphingosine-1-Phosphate in Transplant Vasculopathy Evoked by Anti-HLA Antibody. | 2015 | Am. J. Transplant. | pmid:25930666 |
Pulkoski-Gross MJ et al. | Sphingosine-1-phosphate metabolism: A structural perspective. | 2015 | Crit. Rev. Biochem. Mol. Biol. | pmid:25923252 |
Ader I et al. | Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer. | 2015 | Oncotarget | pmid:25915662 |