Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Gueguen G et al. | Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. | 1999 | Biochemistry | pmid:10387090 |
Tolan D et al. | Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. | 1999 | Cell. Signal. | pmid:10376808 |
Okamoto H et al. | EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10381367 |
Edsall LC and Spiegel S | Enzymatic measurement of sphingosine 1-phosphate. | 1999 | Anal. Biochem. | pmid:10405296 |
Rakhit S et al. | Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase. | 1999 | Biochem. J. | pmid:10051434 |
Spiegel S | Sphingosine 1-phosphate: a prototype of a new class of second messengers. | 1999 | J. Leukoc. Biol. | pmid:10080537 |
Liu CH et al. | Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. | 1999 | Mol. Biol. Cell | pmid:10198065 |
Watanabe Y and Akaike T | Possible involvement of caspase-like family in maintenance of cytoskeleton integrity. | 1999 | J. Cell. Physiol. | pmid:10082131 |
Shinpo K et al. | Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. | 1999 | Brain Res. | pmid:10082875 |
Wang F et al. | Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate. | 1999 | Exp. Cell Res. | pmid:10047444 |
Goetzl EJ et al. | Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. | 1999 | Cancer Res. | pmid:10493533 |
Goetzl EJ et al. | Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. | 1999 | Cancer Res. | pmid:10537322 |
Hla T et al. | Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? | 1999 | Biochem. Pharmacol. | pmid:10423159 |
Prieschl EE et al. | The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. | 1999 | J. Exp. Med. | pmid:10429665 |
Sato K et al. | Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor. | 1999 | FEBS Lett. | pmid:9928946 |
Hung WC et al. | Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells. | 1999 | Biochem. J. | pmid:9931312 |
Zhang G et al. | Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. | 1999 | Gene | pmid:9931453 |
Moolenaar WH | Bioactive lysophospholipids and their G protein-coupled receptors. | 1999 | Exp. Cell Res. | pmid:10579925 |
Yang L et al. | Metabolism and functional effects of sphingolipids in blood cells. | 1999 | Br. J. Haematol. | pmid:10583213 |
Sato K et al. | Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. | 1999 | Mol. Pharmacol. | pmid:9882706 |
Lynch KR and Im DS | Life on the edg. | 1999 | Trends Pharmacol. Sci. | pmid:10603487 |
Sato K et al. | Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. | 1999 | Brain Res. Mol. Brain Res. | pmid:10640689 |
Goetzl EJ et al. | Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. | 1999 | J. Immunol. | pmid:9973477 |
English D et al. | Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis. | 1999 | J. Hematother. Stem Cell Res. | pmid:10645770 |
Lee MJ et al. | Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. | 1999 | Cell | pmid:10555146 |
Guo J et al. | Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells. | 1999 | Pflugers Arch. | pmid:10555561 |
Hong G et al. | Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells. | 1999 | FEBS Lett. | pmid:10556527 |
De Jonghe S et al. | Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560747 |
Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
Stewart CE et al. | Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis. | 1999 | Exp. Cell Res. | pmid:10413587 |
Gottlieb D et al. | The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. | 1999 | Mol. Cell Biol. Res. Commun. | pmid:10329480 |
Denisova NA et al. | The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. | 1999 | Free Radic. Biol. Med. | pmid:10641723 |
Van Brocklyn JR et al. | Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. | 1999 | J. Biol. Chem. | pmid:9988698 |
Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
Alemany R et al. | Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:9933590 |
Zhang Q et al. | Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. | 1999 | Blood | pmid:10216094 |
Goetzl EJ et al. | Lysophospholipid enhancement of human T cell sensitivity to diphtheria toxin by increased expression of heparin-binding epidermal growth factor. | 1999 May-Jun | Proc. Assoc. Am. Physicians | pmid:10354366 |
Sato K et al. | Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. | 2000 | Brain Res. Mol. Brain Res. | pmid:11146117 |
Hla T et al. | Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818438 |
Spiegel S | Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818441 |
Ancellin N and Hla T | Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818459 |
Yamamura S et al. | Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818470 |
Shimizu H et al. | Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets. | 2000 | Endocr. J. | pmid:11036869 |
MacLennan AJ et al. | Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. | 2000 | Dev. Neurosci. | pmid:10965150 |
Nakajima N et al. | Expression and characterization of Edg-1 receptors in rat cardiomyocytes: calcium deregulation in response to sphingosine 1-phosphate. | 2000 | Eur. J. Biochem. | pmid:10971577 |
Parrill AL et al. | Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. | 2000 | J. Biol. Chem. | pmid:10982820 |
Davaille J et al. | Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. | 2000 | J. Biol. Chem. | pmid:10942778 |
Ikeda H et al. | Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10915638 |
Yamazaki Y et al. | Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679247 |
Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |