Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
Boujaoude LC et al. | Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. | 2001 | J. Biol. Chem. | pmid:11443135 |
Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
Yoshida A and Ueda H | Neurobiology of the Edg2 lysophosphatidic acid receptor. | 2001 | Jpn. J. Pharmacol. | pmid:11700008 |
Im DS et al. | Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. | 2001 | Biochemistry | pmid:11705398 |
Rosenfeldt HM et al. | The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. | 2001 | Biochem. Soc. Trans. | pmid:11709084 |
Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
Rosenfeldt HM et al. | EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. | 2001 | FASEB J. | pmid:11726541 |
Lampasso JD et al. | Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728164 |
Hla T et al. | Lysophospholipids--receptor revelations. | 2001 | Science | pmid:11729304 |
Muraki K and Imaizumi Y | A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells. | 2001 | J. Physiol. (Lond.) | pmid:11731576 |
Lee MJ et al. | Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. | 2001 | Mol. Cell | pmid:11583630 |
Li G et al. | Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. | 2001 | Development | pmid:11566853 |
Bischoff A et al. | Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11534858 |
Robert P et al. | EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549339 |
Marletta MA | Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? | 2001 | Trends Biochem. Sci. | pmid:11551775 |
Ohmori T et al. | G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. | 2001 | J. Biol. Chem. | pmid:11056155 |
Erl W and Siess W | Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. | 2001 | Circ. Res. | pmid:11557732 |
Malek RL et al. | Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. | 2001 | J. Biol. Chem. | pmid:11069896 |
Kluk MJ and Hla T | Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. | 2001 | Circ. Res. | pmid:11557736 |
Meacci E et al. | Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. | 2001 | Cell. Signal. | pmid:11483412 |
Pébay A et al. | Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. | 2001 | Eur. J. Neurosci. | pmid:11467306 |
Okajima F | [Establishment of the method for the measurement of sphingosine-1-phosphate in biological samples and its application for S1P research]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11778456 |
Mandala SM | Sphingosine-1-phosphate phosphatases. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324704 |
Lynch KR and Macdonald TL | Structure activity relationships of lysophospholipid mediators. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324706 |
Panetti TS et al. | Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324710 |
Alderton F et al. | G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11278307 |
Igarashi J et al. | Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278407 |
Morales-Ruiz M et al. | Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278592 |
Birchwood CJ et al. | Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. | 2001 | J. Biol. Chem. | pmid:11278643 |
Ng CK et al. | Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | 2001 | Nature | pmid:11279499 |
Kranenburg O and Moolenaar WH | Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. | 2001 | Oncogene | pmid:11313900 |
Schwartz BM et al. | Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. | 2001 | Gynecol. Oncol. | pmid:11330965 |
Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
Alderton F et al. | Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. | 2001 | J. Biol. Chem. | pmid:11359779 |
Pébay A et al. | Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. | 2001 | Eur. J. Neurosci. | pmid:11422447 |
Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
Ishii I et al. | Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. | 2001 | J. Biol. Chem. | pmid:11443127 |
Kralik SF et al. | A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. | 2001 | Anal. Biochem. | pmid:11444818 |
Wells CD et al. | Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. | 2001 | J. Biol. Chem. | pmid:11384980 |
Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
Repp H et al. | Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284444 |
Takuwa Y et al. | Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. | 2001 | Mol. Cell. Endocrinol. | pmid:11377814 |
Banno Y et al. | Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. | 2001 | J. Biol. Chem. | pmid:11468290 |
Tilly JL | Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. | 2001 | ScientificWorldJournal | pmid:12805661 |
Blaukat A and Dikic I | Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. | 2001 | Biol. Chem. | pmid:11258664 |
Grey A et al. | The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | 2002 | Endocrinology | pmid:12446603 |
Kihara A and Igarashi Y | [Sphingosine 1-phosphate in yeast]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915338 |
Meacci E et al. | A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. | 2002 | FEBS Lett. | pmid:12067705 |
Le Stunff H et al. | Sphingosine-1-phosphate and lipid phosphohydrolases. | 2002 | Biochim. Biophys. Acta | pmid:12069805 |