| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Wang F et al. | Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate. | 1999 | Exp. Cell Res. | pmid:10047444 |
| Rakhit S et al. | Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase. | 1999 | Biochem. J. | pmid:10051434 |
| Spiegel S | Sphingosine 1-phosphate: a prototype of a new class of second messengers. | 1999 | J. Leukoc. Biol. | pmid:10080537 |
| Watanabe Y and Akaike T | Possible involvement of caspase-like family in maintenance of cytoskeleton integrity. | 1999 | J. Cell. Physiol. | pmid:10082131 |
| Shinpo K et al. | Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. | 1999 | Brain Res. | pmid:10082875 |
| Liu CH et al. | Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. | 1999 | Mol. Biol. Cell | pmid:10198065 |
| Zhang Q et al. | Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. | 1999 | Blood | pmid:10216094 |
| Gottlieb D et al. | The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. | 1999 | Mol. Cell Biol. Res. Commun. | pmid:10329480 |
| Huang JS et al. | Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10334873 |
| Goetzl EJ et al. | Lysophospholipid enhancement of human T cell sensitivity to diphtheria toxin by increased expression of heparin-binding epidermal growth factor. | 1999 May-Jun | Proc. Assoc. Am. Physicians | pmid:10354366 |
| Hisano N et al. | Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. | 1999 | Blood | pmid:10361127 |
| Meacci E et al. | Effect of Rho and ADP-ribosylation factor GTPases on phospholipase D activity in intact human adenocarcinoma A549 cells. | 1999 | J. Biol. Chem. | pmid:10373471 |
| Tolan D et al. | Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. | 1999 | Cell. Signal. | pmid:10376808 |
| Okamoto H et al. | EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10381367 |
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| Gueguen G et al. | Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. | 1999 | Biochemistry | pmid:10387090 |
| Dallalio G et al. | Inhibition of human erythroid colony formation by ceramide. | 1999 | Exp. Hematol. | pmid:10390188 |
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| Stewart CE et al. | Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis. | 1999 | Exp. Cell Res. | pmid:10413587 |
| Kozawa O et al. | Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells. | 1999 | Exp. Cell Res. | pmid:10413591 |
| Augé N et al. | Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:10419457 |
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| Prieschl EE et al. | The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. | 1999 | J. Exp. Med. | pmid:10429665 |
| Hotchin NA et al. | Differential activation of focal adhesion kinase, Rho and Rac by the ninth and tenth FIII domains of fibronectin. | 1999 | J. Cell. Sci. | pmid:10444388 |
| Kon J et al. | Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. | 1999 | J. Biol. Chem. | pmid:10446161 |
| Dygas A et al. | Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. | 1999 | Acta Biochim. Pol. | pmid:10453985 |
| Wójcik M and Barańska J | Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. | 1999 | Acta Biochim. Pol. | pmid:10453988 |
| Waeber C and Chiu ML | In vitro autoradiographic visualization of guanosine-5'-O-(3-[35S]thio)triphosphate binding stimulated by sphingosine 1-phosphate and lysophosphatidic acid. | 1999 | J. Neurochem. | pmid:10461914 |
| Meacci E et al. | Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C. | 1999 | FEBS Lett. | pmid:10471775 |
| Windh RT et al. | Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. | 1999 | J. Biol. Chem. | pmid:10488065 |
| Banno Y et al. | Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin. | 1999 | J. Biol. Chem. | pmid:10488069 |
| Kozawa O et al. | Sphingosine 1-phosphate induces heat shock protein 27 via p38 mitogen-activated protein kinase activation in osteoblasts. | 1999 | J. Bone Miner. Res. | pmid:10491224 |
| Goetzl EJ et al. | Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. | 1999 | Cancer Res. | pmid:10493533 |
| Cavallini L et al. | Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10510273 |
| Goetzl EJ et al. | Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. | 1999 | Cancer Res. | pmid:10537322 |
| Lee OH et al. | Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10544002 |
| Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
| Xia P et al. | High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL. | 1999 | J. Biol. Chem. | pmid:10551885 |
| Lee MJ et al. | Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. | 1999 | Cell | pmid:10555146 |
| Guo J et al. | Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells. | 1999 | Pflugers Arch. | pmid:10555561 |
| Hong G et al. | Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells. | 1999 | FEBS Lett. | pmid:10556527 |
| De Jonghe S et al. | Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560747 |
| Olivera A et al. | Assaying sphingosine kinase activity. | 2000 | Meth. Enzymol. | pmid:10563328 |
| Brindley DN et al. | Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. | 2000 | Meth. Enzymol. | pmid:10563330 |
| Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
| Meyer zu Heringdorf D et al. | Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor. | 1999 | FEBS Lett. | pmid:10567700 |
| Moore AN et al. | Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. | 1999 | Neuroscience | pmid:10579204 |
| Moolenaar WH | Bioactive lysophospholipids and their G protein-coupled receptors. | 1999 | Exp. Cell Res. | pmid:10579925 |
| Yang L et al. | Metabolism and functional effects of sphingolipids in blood cells. | 1999 | Br. J. Haematol. | pmid:10583213 |
| Wang F et al. | Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. | 1999 | J. Biol. Chem. | pmid:10585401 |
| Vasta V et al. | Sphingosine 1-phosphate induces arachidonic acid mobilization in A549 human lung adenocarcinoma cells. | 2000 | Biochim. Biophys. Acta | pmid:10601704 |
| Lynch KR and Im DS | Life on the edg. | 1999 | Trends Pharmacol. Sci. | pmid:10603487 |
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| Wang F et al. | Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. | 1999 | Cancer Res. | pmid:10626811 |
| Sato K et al. | Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. | 1999 | Brain Res. Mol. Brain Res. | pmid:10640689 |
| Denisova NA et al. | The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. | 1999 | Free Radic. Biol. Med. | pmid:10641723 |
| English D et al. | Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis. | 1999 | J. Hematother. Stem Cell Res. | pmid:10645770 |
| Rümenapp U et al. | Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10651140 |
| Lee OH et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652210 |
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| Carpio LC et al. | Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670688 |
| Yamazaki Y et al. | Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679247 |
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| Motohashi K et al. | Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. | 2000 | FEBS Lett. | pmid:10692584 |
| Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
| Sugiyama A et al. | Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. | 2000 | Cardiovasc. Res. | pmid:10727660 |
| Van Brocklyn JR et al. | Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. | 2000 | Blood | pmid:10753843 |
| Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
| Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
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| Goetzl EJ et al. | Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes. | 2000 | J. Immunol. | pmid:10799850 |
| Meacci E et al. | Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. | 2000 | FEBS Lett. | pmid:10802049 |
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| Spiegel S | Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818441 |
| Ancellin N and Hla T | Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818459 |
| Yamamura S et al. | Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818470 |
| Gallois C et al. | Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818472 |
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| Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
| Caligan TB et al. | A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. | 2000 | Anal. Biochem. | pmid:10847608 |
| Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
| Mandala SM et al. | Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10859351 |
| Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
| Murata N et al. | Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. | 2000 | Anal. Biochem. | pmid:10860507 |
| Siess W et al. | Lysophosphatidic acid and sphingosine 1-phosphate: two lipid villains provoking cardiovascular diseases? | 2000 | IUBMB Life | pmid:10868905 |
| Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
| Sugiyama A et al. | Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | 2000 | Jpn. J. Pharmacol. | pmid:10875754 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: signaling inside and out. | 2000 | FEBS Lett. | pmid:10878250 |
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling in mammalian cells. | 2000 | Biochem. J. | pmid:10880336 |
| Yanai N et al. | Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers. | 2000 | Blood | pmid:10891442 |
| Himmel HM et al. | Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. | 2000 | Mol. Pharmacol. | pmid:10908314 |
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