| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kozawa O et al. | Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts. | 1997 | FEBS Lett. | pmid:9414115 |
| Sato K et al. | Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9388477 |
| Kiss Z et al. | Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine. | 1997 | Biochem. J. | pmid:9371692 |
| Saba JD et al. | The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. | 1997 | J. Biol. Chem. | pmid:9334171 |
| Törnquist K et al. | Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells. | 1997 | Endocrinology | pmid:9322911 |
| Kozawa O et al. | Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. | 1997 | J. Biol. Chem. | pmid:9312119 |
| Orlati S et al. | Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. | 1997 | Biochim. Biophys. Acta | pmid:9296526 |
| Edsall LC et al. | Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. | 1997 | J. Neurosci. | pmid:9278531 |
| Yamamura S et al. | Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. | 1997 | Biochemistry | pmid:9271506 |
| Kiss Z and Mukherjee JJ | Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism. | 1997 | FEBS Lett. | pmid:9257719 |
| Blakesley VA et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. | 1997 | J. Biol. Chem. | pmid:9195921 |
| Yatomi Y et al. | Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. | 1997 | J. Biochem. | pmid:9192741 |
| Wang F et al. | Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. | 1997 | Biochem. J. | pmid:9182707 |
| Yamada T et al. | Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions. | 1997 | Cell. Mol. Life Sci. | pmid:9176562 |
| Im DS et al. | Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes. | 1997 | Am. J. Physiol. | pmid:9176218 |
| Shatrov VA et al. | Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9168973 |
| Shirahama T et al. | Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. | 1997 | FEBS Lett. | pmid:9141489 |
| Törnquist K | Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. | 1997 | Am. J. Physiol. | pmid:9124507 |
| Yatomi Y et al. | Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues. | 1997 | FEBS Lett. | pmid:9119058 |
| Rani CS et al. | Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. | 1997 | J. Biol. Chem. | pmid:9099730 |
| Yatomi Y et al. | Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. | 1997 | J. Biol. Chem. | pmid:9030602 |
| Mano N et al. | Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. | 1997 | Anal. Biochem. | pmid:9025946 |
| Chung T et al. | ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. | 1997 | J. Biol. Chem. | pmid:9006957 |
| Okajima F et al. | Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. | 1997 | Endocrinology | pmid:8977407 |
| Yang L et al. | Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954916 |
| Hung WC and Chuang LY | Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954076 |
| Spiegel S and Merrill AH | Sphingolipid metabolism and cell growth regulation. | 1996 | FASEB J. | pmid:8903509 |
| Meyer zu Heringdrof D et al. | Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8897440 |
| Bünemann M et al. | A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. | 1996 | EMBO J. | pmid:8896446 |
| Hashizume T et al. | Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets. | 1996 | J. Biochem. | pmid:8864845 |
| Berger A et al. | Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. | 1996 | Mol. Pharmacol. | pmid:8794881 |
| Bünemann M et al. | Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate. | 1995 | J. Physiol. (Lond.) | pmid:8788935 |
| Postma FR et al. | Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. | 1996 | EMBO J. | pmid:8665846 |
| Waggoner DW et al. | Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. | 1996 | J. Biol. Chem. | pmid:8663293 |
| Cuvillier O et al. | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. | 1996 | Nature | pmid:8657285 |
| Van Koppen CJ et al. | A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. | 1996 | Mol. Pharmacol. | pmid:8649355 |
| Pyne S et al. | Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. | 1996 | Eur. J. Biochem. | pmid:8647130 |
| Yamamura S et al. | Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. | 1996 | FEBS Lett. | pmid:8612751 |
| Okajima F et al. | Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells. | 1996 | FEBS Lett. | pmid:8603702 |
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| Yatomi Y et al. | N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. | 1996 | Biochemistry | pmid:8555236 |
| Fatatis A and Miller RJ | Sphingosine and sphingosine 1-phosphate differentially modulate platelet-derived growth factor-BB-induced Ca2+ signaling in transformed oligodendrocytes. | 1996 | J. Biol. Chem. | pmid:8550576 |
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| Su Y et al. | Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts. | 1994 | J. Biol. Chem. | pmid:8206962 |