Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Che W et al. Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24032470
Chang N et al. Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. 2014 J. Cell. Biochem. pmid:24038457
Völzke A et al. Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. 2014 Biochim. Biophys. Acta pmid:24064301
Pyne NJ et al. The role of sphingosine 1-phosphate in inflammation and cancer. 2014 Adv Biol Regul pmid:24070975
Nguyen-Tran DH et al. Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. 2014 Dis Model Mech pmid:24077965
Tanaka K et al. Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. 2014 Clin. Exp. Immunol. pmid:24028747
Kihara A Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. 2014 Biochim. Biophys. Acta pmid:23994042
Moxon JV et al. Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. 2014 Circ Cardiovasc Genet pmid:24448739
Gorlino CV et al. Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes. 2014 J. Immunol. pmid:25015824
Anderson G and Maes M Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. 2014 CNS Neurol Disord Drug Targets pmid:24040808
Waeber C and Walther T Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction. 2014 Circ. J. pmid:24632793
Brünnert D et al. Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. 2014 Mol. Hum. Reprod. pmid:24994816
Willinger T et al. Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. 2014 J. Exp. Med. pmid:24638168
Purschke WG et al. Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. 2014 Biochem. J. pmid:24832383
Karaca I et al. Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. 2014 J. Biol. Chem. pmid:24808180
Fayyaz S et al. Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. 2014 Diabetologia pmid:24292566
Nagamatsu T et al. Emerging roles for lysophospholipid mediators in pregnancy. 2014 Am. J. Reprod. Immunol. pmid:24689547
Shimizu Y et al. Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. 2014 Am. J. Pathol. pmid:24641902
Langeslag M et al. Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. 2014 Mol Pain pmid:25431213
Callihan P et al. Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. 2014 ASN Neuro pmid:25424429
Kułakowska A et al. Increased levels of sphingosine-1-phosphate in cerebrospinal fluid of patients diagnosed with tick-borne encephalitis. 2014 J Neuroinflammation pmid:25421616
Gomes L et al. Sphingosine 1-phosphate in acute dengue infection. 2014 PLoS ONE pmid:25409037
Miller DS Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. 2014 J. Pharmacol. Exp. Ther. pmid:24385389
Xu M et al. FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. 2014 Acta Pharmacol. Sin. pmid:25399649
Watanabe C et al. Antagonism and synergy of single chain sphingolipids sphingosine and sphingosine-1-phosphate toward lipid bilayer properties. Consequences for their role as cell fate regulators. 2014 Langmuir pmid:25386673
Dai L et al. Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy? 2014 Cancer Invest. pmid:24499107
Ito K et al. Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24516133
Nakajima C et al. The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. 2014 Development pmid:25377550
Takeshita E et al. Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. 2014 Biochem. Biophys. Res. Commun. pmid:24486543
Barnes J and Dweik RA Is pulmonary hypertension a metabolic disease? 2014 Am. J. Respir. Crit. Care Med. pmid:25360726
Kamiya T et al. Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro. 2014 Exp. Eye Res. pmid:24486793
Chen J et al. Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. 2014 PLoS Genet. pmid:25356849
Plano D et al. Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. 2014 J. Med. Chem. pmid:24471412
Nakamura H and Murayama T Role of sphingolipids in arachidonic acid metabolism. 2014 J. Pharmacol. Sci. pmid:24599139
Guo S et al. Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. 2014 Biochim. Biophys. Acta pmid:24603322
Kempf A et al. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 PLoS Biol. pmid:24453941
Tao C et al. Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes. 2014 Best Pract. Res. Clin. Endocrinol. Metab. pmid:24417945
Hamidi S et al. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. 2014 Biochim. Biophys. Acta pmid:24440818
Park K et al. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. 2014 J. Nutr. Biochem. pmid:24768661
Schaper K et al. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. 2014 Mol. Immunol. pmid:24434636
Kono M et al. Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. 2014 J. Clin. Invest. pmid:24667638
Sasaki H et al. Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. 2014 Arch. Biochem. Biophys. pmid:24708996
Sutter I et al. Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. 2014 J. Lipid Res. pmid:24950692
Xiong Y et al. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. 2014 J. Clin. Invest. pmid:25250575
Tan SJ et al. Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. 2014 Reprod. Biomed. Online pmid:25246113
Goñi FM et al. Biophysical properties of sphingosine, ceramides and other simple sphingolipids. 2014 Biochem. Soc. Trans. pmid:25233422
Yagoub D et al. Sphingosine kinase 1 isoform-specific interactions in breast cancer. 2014 Mol. Endocrinol. pmid:25216046
Yang W et al. Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. 2014 PLoS ONE pmid:25188412
Chen J et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. 2014 Am. J. Respir. Crit. Care Med. pmid:25180446
Kong Y et al. Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. 2014 Mediators Inflamm. pmid:25147438
Shayegi N et al. CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. 2014 Br. J. Haematol. pmid:24180707
Nagahashi M et al. Sphingosine-1-phosphate transporters as targets for cancer therapy. 2014 Biomed Res Int pmid:25133174
Nguyen AV et al. STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. 2014 World J. Gastroenterol. pmid:25132744
Kim ES et al. Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. 2014 Oncogene pmid:23955082
St John AL et al. S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. 2014 Immunity pmid:25238098
Davis KM and Isberg RR Plague's partners in crime. 2014 Immunity pmid:25238090
Wakashima T et al. Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. 2014 J. Biol. Chem. pmid:25049234
Marfia G et al. Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. 2014 Glia pmid:25042636
Fuerst E et al. Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. 2014 Allergy pmid:25041788
Murakami M et al. Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. 2014 Acta Biomater pmid:25038462
Park SJ et al. Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. 2014 Cell. Signal. pmid:25035231
Kim EY et al. Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. 2014 FASEB J. pmid:25002116
Schwalm S et al. Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. 2014 Basic Clin. Pharmacol. Toxicol. pmid:23789924
Hao J et al. The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. 2014 Arthritis Res. Ther. pmid:25000985
Tsai YC et al. Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. 2014 Reprod Sci pmid:23793475
Rauch BH Sphingosine 1-phosphate as a link between blood coagulation and inflammation. 2014 Cell. Physiol. Biochem. pmid:24977491
Sattler K et al. HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. 2014 Cell. Physiol. Biochem. pmid:24977490
Thuy AV et al. Sphingosine 1-phosphate in blood: function, metabolism, and fate. 2014 Cell. Physiol. Biochem. pmid:24977489
van Echten-Deckert G et al. Sphingosine-1-phosphate: boon and bane for the brain. 2014 Cell. Physiol. Biochem. pmid:24977488
Fayyaz S et al. Divergent role of sphingosine 1-phosphate on insulin resistance. 2014 Cell. Physiol. Biochem. pmid:24977487
Halmer R et al. Sphingolipids: important players in multiple sclerosis. 2014 Cell. Physiol. Biochem. pmid:24977485
BÅ‚ogowski W et al. Perioperative release of pro-regenerative biochemical signals from human renal allografts subjected to ischemia-reperfusion injury. 2014 Innate Immun pmid:23608824
Brizuela L et al. Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. 2014 Mol Oncol pmid:24768038
Poitevin S et al. Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. 2014 Cardiovasc. Res. pmid:24743591
Mahajan-Thakur S et al. Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. 2014 J. Leukoc. Biol. pmid:24990321
O'Sullivan MJ et al. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. 2014 PLoS ONE pmid:24743449
Jesko H et al. Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. 2014 Folia Neuropathol pmid:24729344
Zhu Y et al. Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. 2014 Mol. Neurobiol. pmid:24722820
Kondo S et al. Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. 2014 PLoS ONE pmid:24714781
Korbelik M et al. Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. 2014 Int. Immunopharmacol. pmid:24713544
Gatfield J et al. Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. 2014 Cell. Signal. pmid:24704119
Shin KO et al. Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. 2014 Arch. Pharm. Res. pmid:24687256
Yu H et al. Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. 2014 Injury pmid:24685054
Sykes DA et al. Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization. 2014 Br. J. Pharmacol. pmid:24641481
Zhang J and Song J Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. 2014 Acta Biomater pmid:24631657
Blaho VA and Hla T An update on the biology of sphingosine 1-phosphate receptors. 2014 J. Lipid Res. pmid:24459205
Maeda Y et al. S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. 2014 Int. Immunol. pmid:24343820
Guo L et al. Roles of sphingosine-1-phosphate in reproduction. 2014 Reprod Sci pmid:24336672
Shen Z et al. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). 2014 Cell Stress Chaperones pmid:24293320
Chen JJ et al. Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. 2014 Steroids pmid:24269742
Whisler JA et al. Control of perfusable microvascular network morphology using a multiculture microfluidic system. 2014 Tissue Eng Part C Methods pmid:24151838
Mendes-Braz M et al. The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. 2014 Liver Int. pmid:24107124
Baranowski M et al. Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. 2014 Int J Sport Nutr Exerc Metab pmid:24092763
Jensen T et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. 2014 Bioorg. Med. Chem. Lett. pmid:25442311
Ye C et al. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. 2014 J. Pharmacol. Exp. Ther. pmid:24633425
Pyszko J and Strosznajder JB Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. 2014 Mol. Neurobiol. pmid:24399507
Fincher J et al. G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. 2014 Dev. Neurosci. pmid:25138637
Neuber C et al. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. 2014 Anal. Chem. pmid:25137547
Nishi T et al. Molecular and physiological functions of sphingosine 1-phosphate transporters. 2014 Biochim. Biophys. Acta pmid:23921254
Xia JY et al. The adipokine/ceramide axis: key aspects of insulin sensitization. 2014 Biochimie pmid:23969158