| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kurano M et al. | Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. | 2013 | Atherosclerosis | pmid:23664237 |
| Feuerborn R et al. | High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. | 2017 | Atherosclerosis | pmid:28038379 |
| Sutter I et al. | Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. | 2015 | Atherosclerosis | pmid:26093887 |
| Karuna R et al. | Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism. | 2011 | Atherosclerosis | pmid:21944699 |
| Thors B et al. | Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. | 2003 | Atherosclerosis | pmid:12801607 |
| Peyrin-Biroulet L et al. | Modulation of sphingosine-1-phosphate in inflammatory bowel disease. | 2017 | Autoimmun Rev | pmid:28279838 |
| Morris MA et al. | Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. | 2011 | Autoimmunity | pmid:20695767 |
| Hedemann J et al. | Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. | 2004 | Auton Autacoid Pharmacol | pmid:15541015 |
| Mulders AC et al. | Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. | 2007 | Auton Autacoid Pharmacol | pmid:18076478 |
| Lavieu G et al. | Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? | 2007 Jan-Feb | Autophagy | pmid:17035732 |
| Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
| Mitroi DN et al. | SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. | 2017 | Autophagy | pmid:28521611 |
| Zhang N et al. | FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. | 2010 | Autophagy | pmid:20935520 |
| Schwalm S et al. | Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23789924 |
| Sattler KJ et al. | Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. | 2010 | Basic Res. Cardiol. | pmid:20652276 |
| Kelly RF et al. | Ethanolamine is a novel STAT-3 dependent cardioprotective agent. | 2010 | Basic Res. Cardiol. | pmid:20938668 |
| Knapp M et al. | Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | 2012 | Basic Res. Cardiol. | pmid:22961594 |
| Gomez L et al. | A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection. | 2011 | Basic Res. Cardiol. | pmid:22002221 |
| Tao C et al. | Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes. | 2014 | Best Pract. Res. Clin. Endocrinol. Metab. | pmid:24417945 |
| Jones EE et al. | Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. | 2015 | Bioanalysis | pmid:26505686 |
| Shatrov VA et al. | Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9168973 |
| Okamoto H et al. | EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10381367 |
| Candelore MR et al. | Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12270137 |
| Moriue T et al. | Sphingosine 1-phosphate attenuates H2O2-induced apoptosis in endothelial cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18267109 |
| Malchinkhuu E et al. | S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18088600 |
| Li QF et al. | Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18423379 |
| Betito S and Cuvillier O | Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16414356 |
| Kang JW and Lee SM | Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24997335 |
| Ikeda M et al. | Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15737611 |
| Tang HB et al. | S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29534963 |
| Kim MK et al. | Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16674917 |
| Hu W et al. | Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16574065 |
| Fujii Y et al. | Blocking S1P interaction with S1Pâ‚ receptor by a novel competitive S1Pâ‚-selective antagonist inhibits angiogenesis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387544 |
| Wong RC et al. | Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16616002 |
| Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
| Shida D et al. | Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15649431 |
| Murakami M et al. | Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18466763 |
| Benamer N et al. | Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21420933 |
| Sato K et al. | Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9388477 |
| Sun HY et al. | Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20382120 |
| Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
| Ito K et al. | Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17418101 |
| Liu R et al. | Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677781 |
| Park KS et al. | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17349972 |
| Kawata T et al. | Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15850807 |
| Ignatov A et al. | Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14592418 |
| Bjursell M et al. | G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16887097 |
| Ohkuni A et al. | Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24269233 |
| Hamada K et al. | Involvement of Mac-1-mediated adherence and sphingosine 1-phosphate in survival of phorbol ester-treated U937 cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9535736 |
| Rahman MM et al. | Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25951977 |