| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Radi ZA and Vogel MW | Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. | 2014 | Toxicol Pathol | pmid:24178572 |
| Nagata Y et al. | Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. | 2014 | Exp. Cell Res. | pmid:24960577 |
| Ceccom J et al. | [Sphingosine 1-phosphate as a biomarker for Alzheimer's disease?]. | 2014 | Med Sci (Paris) | pmid:24939530 |
| Tibboel J et al. | Sphingolipids in lung growth and repair. | 2014 | Chest | pmid:24394822 |
| Sassoli C et al. | Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation. | 2014 | PLoS ONE | pmid:25264785 |
| Silva VR et al. | Hypothalamic S1P/S1PR1 axis controls energy homeostasis. | 2014 | Nat Commun | pmid:25255053 |
| Hirata N et al. | Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. | 2014 | Nat Commun | pmid:25254944 |
| Arnon TI and Cyster JG | Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728595 |
| Oldstone MB and Rosen H | Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728596 |
| Martin R and Sospedra M | Sphingosine-1 phosphate and central nervous system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728597 |
| Belvitch P et al. | Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. | 2014 | Microvasc. Res. | pmid:25072537 |
| Mendes-da-Cruz DA et al. | Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. | 2014 | PLoS ONE | pmid:25068647 |
| Rahman MM et al. | Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. | 2014 | PLoS ONE | pmid:24647471 |
| Park SM et al. | Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. | 2014 | Eur. J. Immunol. | pmid:24825162 |
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| Vanoli E et al. | Vagomimetic effects of fingolimod: physiology and clinical implications. | 2014 | CNS Neurosci Ther | pmid:24836740 |
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| Koch A et al. | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. | 2013 | Biochim. Biophys. Acta | pmid:23906789 |
| Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
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| Arce FT et al. | Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. | 2013 | Nanomedicine | pmid:23523769 |
| Herr DR et al. | Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. | 2013 | J. Biol. Chem. | pmid:24003216 |
| Dave JM et al. | Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). | 2013 | J. Biol. Chem. | pmid:24005669 |
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| Southern C et al. | Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. | 2013 | J Biomol Screen | pmid:23396314 |
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| Ley S et al. | The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. | 2013 | Oncogene | pmid:22410777 |
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