sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?


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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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NCBI Entrez Crosslinks

All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
pmid:
Barth BM et al. PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. 2013 ACS Nano pmid:23373542
Baranowski M et al. Exercise increases plasma levels of sphingoid base-1 phosphates in humans. 2011 Acta Physiol (Oxf) pmid:21535416
Shimizu Y et al. Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. 2014 Am. J. Pathol. pmid:24641902
Sánchez BA et al. Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. 2011 Anal Bioanal Chem pmid:21394454
Berdyshev EV et al. Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. 2005 Anal. Biochem. pmid:15766719
Crowther GJ and Lynch DV Characterization of sphinganine kinase activity in corn shoot microsomes. 1997 Arch. Biochem. Biophys. pmid:9016824
Kim DH et al. Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. 2007 Arch. Pharm. Res. pmid:17879749
Bu S et al. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. 2010 Arthritis Rheum. pmid:20309867
Knapp M et al. Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. 2012 Basic Res. Cardiol. pmid:22961594