sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?


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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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NCBI Entrez Crosslinks

All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
Katsuma S et al. Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. 2002 Genes Cells pmid:12485162
Kihara A et al. Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. 2003 Genes Cells pmid:12786943
Riley RT et al. A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. 2015 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:25833119
Gijsbers S et al. N-acetyl-sphingenine-1-phosphate is a potent calcium mobilizing agent. 1999 FEBS Lett. pmid:10405158
Bu S et al. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. 2006 FASEB J. pmid:16278291
Ceglarek U et al. Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. 2014 Clin. Chim. Acta pmid:24768784
Scherer M et al. High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. 2009 Clin. Chem. pmid:19325012
Tardieu D et al. Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. 2006 Chem. Biol. Interact. pmid:16412405
Niedernberg A et al. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. 2003 Cell. Signal. pmid:12618218
Berdyshev EV et al. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. 2006 Cell. Signal. pmid:16529909
Uhlenbrock K et al. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. 2002 Cell. Signal. pmid:12220620
Shi L et al. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. 2007 Cell Res. pmid:18059378
Fossetta J et al. Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate. 2004 Br. J. Pharmacol. pmid:15197107
Van Brocklyn JR et al. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. 2000 Blood pmid:10753843
Gelineau-van Waes J et al. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. 2012 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:22991331
Jin YX et al. A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. 2012 Bioresour. Technol. pmid:22940331
Goldin E et al. Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver. 1992 Biochim. Biophys. Acta pmid:1324734
Dickson RC and Lester RL Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. 1999 Biochim. Biophys. Acta pmid:10366774
Mao C et al. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. 1999 Biochem. J. pmid:10477278
Inagaki Y et al. Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. 2005 Biochem. J. pmid:15733055