sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.
To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulinoma | D007340 | 28 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Niemann-Pick Disease, Type A | D052536 | 1 associated lipids |
| Niemann-Pick Disease, Type B | D052537 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liliom K et al. | Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. | 2001 | Biochem. J. | pmid:11256963 |
| Schnurbus R et al. | Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine. | 2002 | Biochem. J. | pmid:11829755 |
| Kovacs E and Liliom K | Sphingosylphosphorylcholine as a novel calmodulin inhibitor. | 2008 | Biochem. J. | pmid:17979830 |
| Mallampalli RK et al. | Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. | 1996 | Biochem. J. | pmid:8761490 |
| Brailoiu E et al. | Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | 2003 | Biochem. J. | pmid:12749764 |
| Callahan JW et al. | Studies on the hydrophobic properties of sphingomyelinase. | 1981 | Biochem. J. | pmid:6272705 |
| DAWSON RM | The reported occurrence of sphingosylphosphorylcholine in animal tissues. | 1958 | Biochem. J. | pmid:13522629 |
| Choi H et al. | Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. | 2010 | Biochem. Pharmacol. | pmid:20230798 |
| Wirrig C et al. | Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. | 2016 | Biochem. Pharmacol. | pmid:27402344 |
| Nofer JR et al. | Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. | 2000 | Biochemistry | pmid:11106499 |