sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Insulinoma D007340 28 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Murakami N et al. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. 2004 J. Biol. Chem. pmid:15280385
Kostenis E Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands. 2004 J. Cell. Biochem. pmid:15258916
Yagmurlu A et al. A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling. 2004 Pediatr. Surg. Int. pmid:15185106
Kye KC et al. Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. 2004 J. Invest. Dermatol. pmid:15175025
Li Z et al. The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine. 2004 Chem. Phys. Lipids pmid:15172836
Teisseyre A and Michalak K The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. 2004 Eur. Biophys. J. pmid:15014908
Miura Y et al. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. 2004 FEBS Lett. pmid:14741383
Deguchi H et al. Sphingolipids as bioactive regulators of thrombin generation. 2004 J. Biol. Chem. pmid:14722105
Higuchi K et al. Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes. 2003 Pigment Cell Res. pmid:14629725
Clair T et al. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. 2003 Cancer Res. pmid:14500380
DAWSON RM The reported occurrence of sphingosylphosphorylcholine in animal tissues. 1958 Biochem. J. pmid:13522629
Beil M et al. Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. 2003 Nat. Cell Biol. pmid:12942086
Arikawa K et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. 2003 J. Biol. Chem. pmid:12810709
Brailoiu E and Dun NJ Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings. 2003 Mol. Pharmacol. pmid:12761354
Brailoiu E et al. Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). 2003 Biochem. J. pmid:12749764
Yasukochi M et al. Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine. 2003 Pflugers Arch. pmid:12632186
Ignatov A et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. 2003 J. Neurosci. pmid:12574419
Altmann C et al. Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. 2003 Br. J. Pharmacol. pmid:12569068
Suhr KB et al. Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. 2003 Arch. Dermatol. Res. pmid:12563540
Altmann C et al. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. 2003 Br. J. Pharmacol. pmid:12522098