sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Xin C et al. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. 2007 J. Lipid Res. pmid:17592175
Tobo M et al. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. 2007 Cell. Signal. pmid:17462861
Moon HJ et al. Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells. 2007 Int. J. Biochem. Cell Biol. pmid:17481939
Afrasiabi E et al. Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase. 2007 Mol. Cell. Endocrinol. pmid:17606321
Chiulli N et al. Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease. 2007 Eur. J. Neurosci. pmid:17666077
Kwon YB et al. Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. 2007 J. Dermatol. Sci. pmid:17321112
Kinoshita H et al. Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery. 2007 Anesth. Analg. pmid:17646484
Han M et al. Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. 2007 Prostaglandins Other Lipid Mediat. pmid:17991619
Kim YS et al. The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells. 2007 Arch. Pharm. Res. pmid:18254249
Michel AD and Fonfria E Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. 2007 Br. J. Pharmacol. pmid:17700717
Kishi H et al. [Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction]. 2007 Nippon Yakurigaku Zasshi pmid:17435334
Xu D et al. Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts. 2007 FEBS Lett. pmid:17950286
Oh JT et al. Quantification of the wound healing using polarization-sensitive optical coherence tomography. 2006 Jul-Aug J Biomed Opt pmid:16965152
Afrasiabi E et al. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. 2006 Cell. Signal. pmid:16490345
Czyborra C et al. Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521006
Urs AN et al. Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. 2006 Endocrinology pmid:16887917
Fujiwaki T et al. Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient with Fabry disease. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16431168
Retraction. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. 2006 Nat. Cell Biol. pmid:16508674
Katayama T et al. Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells. 2006 J. Pharmacol. Sci. pmid:17072099
Hemmings DG Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16570136