sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.
To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Niemann-Pick Disease, Type A | D052536 | 1 associated lipids |
| Niemann-Pick Disease, Type B | D052537 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Russell JL et al. | Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease. | 2012 | ACS Chem. Biol. | pmid:22462679 |
| Dygas A et al. | Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. | 1999 | Acta Biochim. Pol. | pmid:10453985 |
| Wójcik M and Barańska J | Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. | 1999 | Acta Biochim. Pol. | pmid:10453988 |
| Suresh S et al. | Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. | 2005 | Acta Biomater | pmid:16701777 |
| Miguel BG et al. | Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes. | 2001 | Acta Neurobiol Exp (Wars) | pmid:11512408 |
| Miguel BG et al. | Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C. | 2008 | Acta Neurobiol Exp (Wars) | pmid:19112467 |
| Michel MC et al. | Vascular effects of sphingolipids. | 2007 | Acta Paediatr Suppl | pmid:17391441 |
| Im DS | Two ligands for a GPCR, proton vs lysolipid. | 2005 | Acta Pharmacol. Sin. | pmid:16297340 |
| Lee HY et al. | Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. | 2006 | Acta Pharmacol. Sin. | pmid:17007744 |