|
|
|
|
pmid:
|
Russell JL et al. |
Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease. |
2012 |
ACS Chem. Biol. |
pmid:22462679
|
Dygas A et al. |
Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. |
1999 |
Acta Biochim. Pol. |
pmid:10453985
|
Wójcik M and Barańska J |
Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. |
1999 |
Acta Biochim. Pol. |
pmid:10453988
|
Suresh S et al. |
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. |
2005 |
Acta Biomater |
pmid:16701777
|
Miguel BG et al. |
Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes. |
2001 |
Acta Neurobiol Exp (Wars) |
pmid:11512408
|
Miguel BG et al. |
Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C. |
2008 |
Acta Neurobiol Exp (Wars) |
pmid:19112467
|
Michel MC et al. |
Vascular effects of sphingolipids. |
2007 |
Acta Paediatr Suppl |
pmid:17391441
|
Im DS |
Two ligands for a GPCR, proton vs lysolipid. |
2005 |
Acta Pharmacol. Sin. |
pmid:16297340
|
Lee HY et al. |
Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. |
2006 |
Acta Pharmacol. Sin. |
pmid:17007744
|
Ge D et al. |
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn. |
2012 |
Acta Pharmacol. Sin. |
pmid:22139003
|
Chin TY and Chueh SH |
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway. |
1998 |
Am. J. Physiol. |
pmid:9814974
|
Yasui K and Palade P |
Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes. |
1996 |
Am. J. Physiol. |
pmid:8779930
|
Bitar KN and Yamada H |
Modulation of smooth muscle contraction by sphingosylphosphorylcholine. |
1995 |
Am. J. Physiol. |
pmid:7573447
|
Wang HH et al. |
Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. |
2009 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:19234090
|
Wang HH et al. |
Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction. |
2008 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:18296570
|
Li S et al. |
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:16899767
|
Murata N et al. |
Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. |
2000 |
Anal. Biochem. |
pmid:10860507
|
Kuchar L et al. |
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases. |
2017 |
Anal. Biochem. |
pmid:28259515
|
Kinoshita H et al. |
Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery. |
2007 |
Anesth. Analg. |
pmid:17646484
|
Liliom K et al. |
Sphingosylphosphorylcholine is a bona fide mediator regulating heart rate. |
2000 |
Ann. N. Y. Acad. Sci. |
pmid:10818471
|
Yamamoto H et al. |
Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages. |
2011 |
Arch. Biochem. Biophys. |
pmid:21081108
|
Suhr KB et al. |
Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. |
2003 |
Arch. Dermatol. Res. |
pmid:12563540
|
Kim YS et al. |
The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells. |
2007 |
Arch. Pharm. Res. |
pmid:18254249
|
Hedemann J et al. |
Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. |
2004 |
Auton Autacoid Pharmacol |
pmid:15541015
|
Mulders AC et al. |
Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. |
2007 |
Auton Autacoid Pharmacol |
pmid:18076478
|
Okamoto H et al. |
EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. |
1999 |
Biochem. Biophys. Res. Commun. |
pmid:10381367
|
Wiktorek-Wójcik M et al. |
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine. |
1997 |
Biochem. Biophys. Res. Commun. |
pmid:9405236
|
Nikmo A et al. |
Sphingosylphosphorylcholine activates Gq, Gi-2, and Gi-3 in thyroid FRTL-5 cells: implications for the activation of calcium fluxes and Na+-H+ exchange. |
1999 |
Biochem. Biophys. Res. Commun. |
pmid:10329469
|
Kovacs E et al. |
Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20851108
|
Boguslawski G et al. |
Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10833459
|
Konno N et al. |
Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells. |
2007 |
Biochem. Biophys. Res. Commun. |
pmid:17935698
|
Desai NN and Spiegel S |
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines. |
1991 |
Biochem. Biophys. Res. Commun. |
pmid:1958205
|
Liu R et al. |
Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. |
1995 |
Biochem. Biophys. Res. Commun. |
pmid:7677781
|
Yue H et al. |
Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25285628
|
Sugiyama E et al. |
Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. |
1990 |
Biochem. Biophys. Res. Commun. |
pmid:2357225
|
Strasberg PM and Callahan JW |
Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine. |
1988 |
Biochem. Cell Biol. |
pmid:2977568
|
Liliom K et al. |
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. |
2001 |
Biochem. J. |
pmid:11256963
|
Schnurbus R et al. |
Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine. |
2002 |
Biochem. J. |
pmid:11829755
|
Orlati S et al. |
Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells. |
1998 |
Biochem. J. |
pmid:9729473
|
Kovacs E and Liliom K |
Sphingosylphosphorylcholine as a novel calmodulin inhibitor. |
2008 |
Biochem. J. |
pmid:17979830
|
Mallampalli RK et al. |
Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. |
1996 |
Biochem. J. |
pmid:8761490
|
Brailoiu E et al. |
Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). |
2003 |
Biochem. J. |
pmid:12749764
|
Callahan JW et al. |
Studies on the hydrophobic properties of sphingomyelinase. |
1981 |
Biochem. J. |
pmid:6272705
|
Betto R et al. |
Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. |
1997 |
Biochem. J. |
pmid:9078280
|
DAWSON RM |
The reported occurrence of sphingosylphosphorylcholine in animal tissues. |
1958 |
Biochem. J. |
pmid:13522629
|
Törnquist K and Ekokoski E |
Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells. |
1994 |
Biochem. J. |
pmid:8166643
|
Choi H et al. |
Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. |
2010 |
Biochem. Pharmacol. |
pmid:20230798
|
Wirrig C et al. |
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. |
2016 |
Biochem. Pharmacol. |
pmid:27402344
|
Lai TS et al. |
Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. |
2001 |
Biochemistry |
pmid:11305905
|
Nofer JR et al. |
Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. |
2000 |
Biochemistry |
pmid:11106499
|
Xu Y |
Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. |
2002 |
Biochim. Biophys. Acta |
pmid:12069813
|
Orlati S et al. |
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. |
1997 |
Biochim. Biophys. Acta |
pmid:9296526
|
Park MK et al. |
Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. |
2011 |
Biochim. Biophys. Acta |
pmid:21840417
|
Jeon ES et al. |
Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells. |
2005 |
Biochim. Biophys. Acta |
pmid:15866480
|
Yue HW et al. |
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy. |
2015 |
Biochim. Biophys. Acta |
pmid:25871970
|
Meyer zu Heringdorf D et al. |
Sphingosylphosphorylcholine-biological functions and mechanisms of action. |
2002 |
Biochim. Biophys. Acta |
pmid:12069827
|
Sakamoto S et al. |
Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study. |
2013 |
Biochim. Biophys. Acta |
pmid:23333324
|
Li W et al. |
Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways. |
2016 |
Biochim. Biophys. Acta |
pmid:27066979
|
Lee EJ et al. |
Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells. |
2016 |
Biochim. Biophys. Acta |
pmid:26876307
|
Berger A et al. |
The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein. |
1998 |
Biochim. Biophys. Acta |
pmid:9507145
|
Pushkareva MYu YA and Hannun |
Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. |
1994 |
Biochim. Biophys. Acta |
pmid:8130276
|
Hitomi K et al. |
Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells. |
2000 |
Biosci. Biotechnol. Biochem. |
pmid:11129585
|
Van Brocklyn JR et al. |
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. |
2000 |
Blood |
pmid:10753843
|
Altmann C et al. |
Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. |
2003 |
Br. J. Pharmacol. |
pmid:12569068
|
Altmann C et al. |
Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. |
2003 |
Br. J. Pharmacol. |
pmid:12522098
|
Alewijnse AE and Michel MC |
Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? |
2006 |
Br. J. Pharmacol. |
pmid:16402045
|
Mathieson FA and Nixon GF |
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. |
2006 |
Br. J. Pharmacol. |
pmid:16402047
|
Michel AD and Fonfria E |
Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. |
2007 |
Br. J. Pharmacol. |
pmid:17700717
|
Bischoff A et al. |
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. |
2000 |
Br. J. Pharmacol. |
pmid:10952677
|
Bischoff A et al. |
Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. |
2000 |
Br. J. Pharmacol. |
pmid:10952678
|
Chin TY and Chueh SH |
Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells. |
2000 |
Br. J. Pharmacol. |
pmid:10742292
|
Huang WC and Chueh SH |
Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum. |
1996 |
Brain Res. |
pmid:8773778
|
Dettbarn C et al. |
Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes. |
1995 |
Brain Res. |
pmid:7712168
|
Clair T et al. |
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. |
2003 |
Cancer Res. |
pmid:14500380
|
Choi SK et al. |
Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. |
2009 |
Cardiovasc. Res. |
pmid:19218288
|
Schubert R |
Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue. |
2005 |
Cardiovasc. Res. |
pmid:16111665
|
Thomas GD et al. |
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. |
2005 |
Cardiovasc. Res. |
pmid:15950201
|
Shaifta Y et al. |
Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species. |
2015 |
Cardiovasc. Res. |
pmid:25661082
|
Orlati S et al. |
Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells. |
1998 |
Cell Calcium |
pmid:9924630
|
Wong K and Kwan-Yeung L |
Sphingosine mobilizes intracellular calcium in human neutrophils. |
1993 |
Cell Calcium |
pmid:8358772
|
Afrasiabi E et al. |
Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. |
2006 |
Cell. Signal. |
pmid:16490345
|
Lee T et al. |
Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK. |
2002 |
Cell. Signal. |
pmid:12359304
|
Kemppainen K et al. |
Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. |
2016 |
Cell. Signal. |
pmid:27634386
|
Tobo M et al. |
Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. |
2007 |
Cell. Signal. |
pmid:17462861
|
Jeon ES et al. |
Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways. |
2005 |
Cell. Signal. |
pmid:15722202
|
Kleger A et al. |
The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. |
2007 |
Cell. Signal. |
pmid:16978842
|
Xu D et al. |
Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts. |
2012 |
Cell. Signal. |
pmid:21951603
|
Shirao S et al. |
Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. |
2008 |
Cerebrovasc. Dis. |
pmid:18511869
|
Yokota K and Ogino T |
Phase separation in lipid bilayer membranes induced by intermixing at a boundary of two phases with different components. |
2015 |
Chem. Phys. Lipids |
pmid:26363303
|
Brahmbhatt VV et al. |
Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. |
2007 |
Chem. Phys. Lipids |
pmid:17126823
|
Li Z et al. |
The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine. |
2004 |
Chem. Phys. Lipids |
pmid:15172836
|
Somlyo AV |
New roads leading to Ca2+ sensitization. |
2002 |
Circ. Res. |
pmid:12142337
|
Shirao S et al. |
Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. |
2002 |
Circ. Res. |
pmid:12142343
|
Sekiguchi K et al. |
Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes. |
1999 |
Circ. Res. |
pmid:10571530
|
Nakao F et al. |
Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. |
2002 |
Circ. Res. |
pmid:12433841
|
Morikage N et al. |
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. |
2006 |
Circ. Res. |
pmid:16825579
|
Jeon ES et al. |
A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. |
2008 |
Circ. Res. |
pmid:18688043
|
Murch O et al. |
Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. |
2008 |
Crit. Care Med. |
pmid:18216604
|
Bünemann M et al. |
A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. |
1996 |
EMBO J. |
pmid:8896446
|