sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
pmid:
Russell JL et al. Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease. 2012 ACS Chem. Biol. pmid:22462679
Dygas A et al. Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. 1999 Acta Biochim. Pol. pmid:10453985
Wójcik M and Barańska J Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. 1999 Acta Biochim. Pol. pmid:10453988
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Miguel BG et al. Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C. 2008 Acta Neurobiol Exp (Wars) pmid:19112467
Michel MC et al. Vascular effects of sphingolipids. 2007 Acta Paediatr Suppl pmid:17391441
Im DS Two ligands for a GPCR, proton vs lysolipid. 2005 Acta Pharmacol. Sin. pmid:16297340
Lee HY et al. Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. 2006 Acta Pharmacol. Sin. pmid:17007744
Ge D et al. Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn. 2012 Acta Pharmacol. Sin. pmid:22139003
Chin TY and Chueh SH Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway. 1998 Am. J. Physiol. pmid:9814974
Yasui K and Palade P Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes. 1996 Am. J. Physiol. pmid:8779930
Bitar KN and Yamada H Modulation of smooth muscle contraction by sphingosylphosphorylcholine. 1995 Am. J. Physiol. pmid:7573447
Wang HH et al. Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19234090
Wang HH et al. Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18296570
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Kinoshita H et al. Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery. 2007 Anesth. Analg. pmid:17646484
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Suhr KB et al. Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. 2003 Arch. Dermatol. Res. pmid:12563540
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Mulders AC et al. Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. 2007 Auton Autacoid Pharmacol pmid:18076478
Okamoto H et al. EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. 1999 Biochem. Biophys. Res. Commun. pmid:10381367
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Kovacs E et al. Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms. 2010 Biochem. Biophys. Res. Commun. pmid:20851108
Boguslawski G et al. Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. 2000 Biochem. Biophys. Res. Commun. pmid:10833459
Konno N et al. Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells. 2007 Biochem. Biophys. Res. Commun. pmid:17935698
Desai NN and Spiegel S Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines. 1991 Biochem. Biophys. Res. Commun. pmid:1958205
Liu R et al. Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. 1995 Biochem. Biophys. Res. Commun. pmid:7677781
Yue H et al. Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells. 2014 Biochem. Biophys. Res. Commun. pmid:25285628
Sugiyama E et al. Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. 1990 Biochem. Biophys. Res. Commun. pmid:2357225
Strasberg PM and Callahan JW Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine. 1988 Biochem. Cell Biol. pmid:2977568
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Mallampalli RK et al. Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. 1996 Biochem. J. pmid:8761490
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Betto R et al. Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. 1997 Biochem. J. pmid:9078280
DAWSON RM The reported occurrence of sphingosylphosphorylcholine in animal tissues. 1958 Biochem. J. pmid:13522629
Törnquist K and Ekokoski E Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells. 1994 Biochem. J. pmid:8166643
Choi H et al. Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:20230798
Wirrig C et al. Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. 2016 Biochem. Pharmacol. pmid:27402344
Nofer JR et al. Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. 2000 Biochemistry pmid:11106499