sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.
To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Niemann-Pick Disease, Type A | D052536 | 1 associated lipids |
| Niemann-Pick Disease, Type B | D052537 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Spangelo BL and Jarvis WD | Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. | 1996 | Endocrinology | pmid:8828503 |
| Urs AN et al. | Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. | 2006 | Endocrinology | pmid:16887917 |
| Rozengurt E and RodrÃguez-Fernández JL | Tyrosine phosphorylation in the action of neuropeptides and growth factors. | 1997 | Essays Biochem. | pmid:9493012 |
| Teisseyre A and Michalak K | The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. | 2004 | Eur. Biophys. J. | pmid:15014908 |
| Törnquist K et al. | Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells. | 1997 | Eur. J. Biochem. | pmid:9346294 |
| Jin Y et al. | Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. | 2005 | Eur. J. Immunol. | pmid:16078278 |
| Chiulli N et al. | Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease. | 2007 | Eur. J. Neurosci. | pmid:17666077 |
| Meyer zu Heringdorf D et al. | Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. | 2001 | Eur. J. Pharmacol. | pmid:11239914 |
| Park MK et al. | Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12. | 2016 | Eur. J. Pharmacol. | pmid:26872988 |
| Meyer zu Heringdorf D et al. | Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine. | 1998 | Eur. J. Pharmacol. | pmid:9726638 |