sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Lee T et al. Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK. 2002 Cell. Signal. pmid:12359304
Ignatov A et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. 2003 J. Neurosci. pmid:12574419
Yasukochi M et al. Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine. 2003 Pflugers Arch. pmid:12632186
Beil M et al. Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. 2003 Nat. Cell Biol. pmid:12942086
Suhr KB et al. Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. 2003 Arch. Dermatol. Res. pmid:12563540
Altmann C et al. Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. 2003 Br. J. Pharmacol. pmid:12569068
Okamoto R et al. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. 2003 J. Lipid Res. pmid:12518027
Altmann C et al. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. 2003 Br. J. Pharmacol. pmid:12522098
Higuchi K et al. Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes. 2003 Pigment Cell Res. pmid:14629725
Brailoiu E et al. Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). 2003 Biochem. J. pmid:12749764
Clair T et al. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. 2003 Cancer Res. pmid:14500380
Brailoiu E and Dun NJ Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings. 2003 Mol. Pharmacol. pmid:12761354
Arikawa K et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. 2003 J. Biol. Chem. pmid:12810709
Yagmurlu A et al. A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling. 2004 Pediatr. Surg. Int. pmid:15185106
Murakami N et al. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. 2004 J. Biol. Chem. pmid:15280385
Kostenis E Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands. 2004 J. Cell. Biochem. pmid:15258916
Kye KC et al. Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. 2004 J. Invest. Dermatol. pmid:15175025
Miura Y et al. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. 2004 FEBS Lett. pmid:14741383
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Deguchi H et al. Sphingolipids as bioactive regulators of thrombin generation. 2004 J. Biol. Chem. pmid:14722105
Teisseyre A and Michalak K The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. 2004 Eur. Biophys. J. pmid:15014908
Hedemann J et al. Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. 2004 Auton Autacoid Pharmacol pmid:15541015
Jin Y et al. Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. 2005 Eur. J. Immunol. pmid:16078278
Suresh S et al. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. 2005 Acta Biomater pmid:16701777
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. 2005 J. Biol. Chem. pmid:16498716
Kamanna VS et al. Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease. 2005 Histol. Histopathol. pmid:15736064
Sakagami H et al. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. 2005 J. Biol. Chem. pmid:15788404
Mogi C et al. Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. 2005 J. Pharmacol. Sci. pmid:16210776
Im DS Two ligands for a GPCR, proton vs lysolipid. 2005 Acta Pharmacol. Sin. pmid:16297340
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Jeon ES et al. Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells. 2005 Biochim. Biophys. Acta pmid:15866480
Piao YJ et al. Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. 2005 Exp. Dermatol. pmid:15854129
Lu X and Bittman R Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. 2005 J. Org. Chem. pmid:15932314
Zhu MJ et al. Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts. 2005 Exp. Dermatol. pmid:15946238
van Diggelen OP et al. A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. 2005 J. Inherit. Metab. Dis. pmid:16151905
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Kim KS et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. 2005 FASEB J. pmid:15857892
Thomas GD et al. Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. 2005 Cardiovasc. Res. pmid:15950201
Afrasiabi E et al. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. 2006 Cell. Signal. pmid:16490345
Czyborra C et al. Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521006
Seuwen K et al. Receptors for protons or lipid messengers or both? 2006 J. Recept. Signal Transduct. Res. pmid:17118800
Alewijnse AE and Michel MC Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? 2006 Br. J. Pharmacol. pmid:16402045
Mathieson FA and Nixon GF Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. 2006 Br. J. Pharmacol. pmid:16402047
Jeon ES et al. Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. 2006 J. Lipid Res. pmid:16339111
Urs AN et al. Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. 2006 Endocrinology pmid:16887917
Fujiwaki T et al. Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient with Fabry disease. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16431168
Retraction. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. 2006 Nat. Cell Biol. pmid:16508674
Katayama T et al. Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells. 2006 J. Pharmacol. Sci. pmid:17072099
Li S et al. Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16899767
Jeon ES et al. Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. 2006 J. Cell. Sci. pmid:17105765
Ryu SK et al. Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521007
Kim DS et al. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. 2006 Pigment Cell Res. pmid:16524430
Morikage N et al. Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. 2006 Circ. Res. pmid:16825579
Lee HY et al. Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. 2006 Acta Pharmacol. Sin. pmid:17007744
Hemmings DG Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16570136
Oh JT et al. Quantification of the wound healing using polarization-sensitive optical coherence tomography. 2006 Jul-Aug J Biomed Opt pmid:16965152
Brahmbhatt VV et al. Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. 2007 Chem. Phys. Lipids pmid:17126823
Yang LV et al. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. 2007 Mol. Cell. Biol. pmid:17145776
Hashiba Y et al. Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. 2007 Neurol. Res. pmid:17806208
Konno N et al. Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells. 2007 Biochem. Biophys. Res. Commun. pmid:17935698
Ceballos A et al. Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12. 2007 Immunology pmid:17371542
Xin C et al. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. 2007 J. Lipid Res. pmid:17592175
Tobo M et al. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. 2007 Cell. Signal. pmid:17462861
Moon HJ et al. Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells. 2007 Int. J. Biochem. Cell Biol. pmid:17481939
Afrasiabi E et al. Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase. 2007 Mol. Cell. Endocrinol. pmid:17606321
Chiulli N et al. Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease. 2007 Eur. J. Neurosci. pmid:17666077
Kwon YB et al. Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. 2007 J. Dermatol. Sci. pmid:17321112
Kinoshita H et al. Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery. 2007 Anesth. Analg. pmid:17646484
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Mulders AC et al. Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. 2007 Auton Autacoid Pharmacol pmid:18076478
Snetkov VA et al. Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. 2008 Hypertension pmid:18158336
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Jeon ES et al. A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. 2008 Circ. Res. pmid:18688043
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Andoh T et al. Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin. 2009 J. Invest. Dermatol. pmid:19657356
Wang HH et al. Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19234090
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Choi H et al. Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:20230798
Kovacs E et al. Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling. 2010 J. Biol. Chem. pmid:19910470
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