sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Nofer JR et al. Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. 2000 Biochemistry pmid:11106499
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Orlati S et al. Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. 1997 Biochim. Biophys. Acta pmid:9296526
Park MK et al. Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. 2011 Biochim. Biophys. Acta pmid:21840417
Jeon ES et al. Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells. 2005 Biochim. Biophys. Acta pmid:15866480
Yue HW et al. Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy. 2015 Biochim. Biophys. Acta pmid:25871970
Meyer zu Heringdorf D et al. Sphingosylphosphorylcholine-biological functions and mechanisms of action. 2002 Biochim. Biophys. Acta pmid:12069827
Sakamoto S et al. Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study. 2013 Biochim. Biophys. Acta pmid:23333324
Li W et al. Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways. 2016 Biochim. Biophys. Acta pmid:27066979
Lee EJ et al. Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells. 2016 Biochim. Biophys. Acta pmid:26876307
Berger A et al. The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein. 1998 Biochim. Biophys. Acta pmid:9507145
Pushkareva MYu YA and Hannun Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. 1994 Biochim. Biophys. Acta pmid:8130276
Hitomi K et al. Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells. 2000 Biosci. Biotechnol. Biochem. pmid:11129585
Van Brocklyn JR et al. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. 2000 Blood pmid:10753843
Altmann C et al. Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. 2003 Br. J. Pharmacol. pmid:12569068
Altmann C et al. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. 2003 Br. J. Pharmacol. pmid:12522098
Alewijnse AE and Michel MC Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? 2006 Br. J. Pharmacol. pmid:16402045
Mathieson FA and Nixon GF Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. 2006 Br. J. Pharmacol. pmid:16402047
Michel AD and Fonfria E Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. 2007 Br. J. Pharmacol. pmid:17700717
Bischoff A et al. Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. 2000 Br. J. Pharmacol. pmid:10952677
Bischoff A et al. Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. 2000 Br. J. Pharmacol. pmid:10952678
Chin TY and Chueh SH Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells. 2000 Br. J. Pharmacol. pmid:10742292
Huang WC and Chueh SH Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum. 1996 Brain Res. pmid:8773778
Dettbarn C et al. Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes. 1995 Brain Res. pmid:7712168
Clair T et al. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. 2003 Cancer Res. pmid:14500380
Choi SK et al. Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. 2009 Cardiovasc. Res. pmid:19218288
Schubert R Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue. 2005 Cardiovasc. Res. pmid:16111665
Thomas GD et al. Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. 2005 Cardiovasc. Res. pmid:15950201
Shaifta Y et al. Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species. 2015 Cardiovasc. Res. pmid:25661082
Orlati S et al. Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells. 1998 Cell Calcium pmid:9924630
Wong K and Kwan-Yeung L Sphingosine mobilizes intracellular calcium in human neutrophils. 1993 Cell Calcium pmid:8358772
Afrasiabi E et al. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. 2006 Cell. Signal. pmid:16490345
Lee T et al. Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK. 2002 Cell. Signal. pmid:12359304
Kemppainen K et al. Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. 2016 Cell. Signal. pmid:27634386
Tobo M et al. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. 2007 Cell. Signal. pmid:17462861
Jeon ES et al. Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways. 2005 Cell. Signal. pmid:15722202
Kleger A et al. The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. 2007 Cell. Signal. pmid:16978842
Xu D et al. Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts. 2012 Cell. Signal. pmid:21951603
Shirao S et al. Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. 2008 Cerebrovasc. Dis. pmid:18511869
Yokota K and Ogino T Phase separation in lipid bilayer membranes induced by intermixing at a boundary of two phases with different components. 2015 Chem. Phys. Lipids pmid:26363303
Brahmbhatt VV et al. Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. 2007 Chem. Phys. Lipids pmid:17126823
Li Z et al. The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine. 2004 Chem. Phys. Lipids pmid:15172836
Somlyo AV New roads leading to Ca2+ sensitization. 2002 Circ. Res. pmid:12142337
Shirao S et al. Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. 2002 Circ. Res. pmid:12142343
Sekiguchi K et al. Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes. 1999 Circ. Res. pmid:10571530
Nakao F et al. Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. 2002 Circ. Res. pmid:12433841
Morikage N et al. Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. 2006 Circ. Res. pmid:16825579
Jeon ES et al. A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. 2008 Circ. Res. pmid:18688043
Murch O et al. Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. 2008 Crit. Care Med. pmid:18216604
Bünemann M et al. A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. 1996 EMBO J. pmid:8896446