sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.
To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Niemann-Pick Disease, Type A | D052536 | 1 associated lipids |
| Niemann-Pick Disease, Type B | D052537 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huwiler A and Pfeilschifter J | Lipids as targets for novel anti-inflammatory therapies. | 2009 | Pharmacol. Ther. | pmid:19576246 |
| Davenport AP et al. | International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. | 2013 | Pharmacol. Rev. | pmid:23686350 |
| Yasukochi M et al. | Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine. | 2003 | Pflugers Arch. | pmid:12632186 |
| Yagmurlu A et al. | A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling. | 2004 | Pediatr. Surg. Int. | pmid:15185106 |
| Brandts B et al. | Inhibition of muscarinic potassium current by the class III antiarrhythmic drug RP58866 in guinea-pig atrial myocytes. | 2000 | Pacing Clin Electrophysiol | pmid:11139931 |
| Kim HJ et al. | Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1. | 2017 | Oncotarget | pmid:28209923 |
| Kishi H et al. | [Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction]. | 2007 | Nippon Yakurigaku Zasshi | pmid:17435334 |
| Ohno K | [Niemann-Pick disease types A and B]. | 1995 | Nippon Rinsho | pmid:8577051 |
| Kudo R and Hatake K | [Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery]. | 2010 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:20681251 |
| Calcerrada MC et al. | Sphingosylphosphorylcholine increases calcium concentration in isolated brain nuclei. | 1999 | Neurosci. Res. | pmid:10211767 |