sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Himmel HM et al. Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells. 1998 Mol. Pharmacol. pmid:9584212
Orlati S et al. Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells. 1998 Cell Calcium pmid:9924630
Chin TY and Chueh SH Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway. 1998 Am. J. Physiol. pmid:9814974
Chen PF et al. Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells. 1998 Kidney Int. pmid:9844123
Orlati S et al. Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells. 1998 Biochem. J. pmid:9729473
Wiktorek-Wójcik M et al. Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine. 1997 Biochem. Biophys. Res. Commun. pmid:9405236
Orlati S et al. Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. 1997 Biochim. Biophys. Acta pmid:9296526
Rozengurt E and Rodríguez-Fernández JL Tyrosine phosphorylation in the action of neuropeptides and growth factors. 1997 Essays Biochem. pmid:9493012
Törnquist K et al. Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells. 1997 Eur. J. Biochem. pmid:9346294
Sueyoshi N et al. Preparation of a naturally occurring D-erythro-(2S, 3R)-sphingosylphosphocholine using Shewanella alga NS-589. 1997 J. Lipid Res. pmid:9323602
Lai TS et al. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. 1997 J. Biol. Chem. pmid:9195933
Betto R et al. Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. 1997 Biochem. J. pmid:9078280
Spangelo BL and Jarvis WD Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. 1996 Endocrinology pmid:8828503
Mallampalli RK et al. Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. 1996 Biochem. J. pmid:8761490
Van Koppen CJ et al. A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. 1996 Mol. Pharmacol. pmid:8649355
Berger A et al. Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. 1996 Mol. Pharmacol. pmid:8794881
Sun L et al. A new wound healing agent--sphingosylphosphorylcholine. 1996 J. Invest. Dermatol. pmid:8601721
Zanglis A et al. The biological activity of acetylated sphingosylphosphorylcholine derivatives. 1996 Int. J. Biochem. Cell Biol. pmid:8624845
Bünemann M et al. A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. 1996 EMBO J. pmid:8896446
Huang WC and Chueh SH Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum. 1996 Brain Res. pmid:8773778
Yasui K and Palade P Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes. 1996 Am. J. Physiol. pmid:8779930
Murata Y et al. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? 1996 J. Invest. Dermatol. pmid:8752664
Furuya S et al. Lysosphingomyelin-elicited Ca2+ mobilization from rat brain microsomes. 1996 J Lipid Mediat Cell Signal pmid:8906576
Okajima F and Kondo Y Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. 1995 J. Biol. Chem. pmid:7592844
Berger A et al. Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7597047
Liu R et al. Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. 1995 Biochem. Biophys. Res. Commun. pmid:7677781
Xu Y et al. Effect of lysophospholipids on signaling in the human Jurkat T cell line. 1995 J. Cell. Physiol. pmid:7775587
Ohno K [Niemann-Pick disease types A and B]. 1995 Nippon Rinsho pmid:8577051
Bitar KN and Yamada H Modulation of smooth muscle contraction by sphingosylphosphorylcholine. 1995 Am. J. Physiol. pmid:7573447
Seufferlein T and Rozengurt E Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein. 1995 J. Biol. Chem. pmid:7592645
Seufferlein T and Rozengurt E Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. 1995 J. Biol. Chem. pmid:7592646
Dettbarn C et al. Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes. 1995 Brain Res. pmid:7712168
Kim S et al. Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel. 1995 J. Biol. Chem. pmid:7890637
Pushkareva MYu YA and Hannun Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. 1994 Biochim. Biophys. Acta pmid:8130276
Törnquist K and Ekokoski E Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells. 1994 Biochem. J. pmid:8166643
Desai NN et al. Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. 1993 J. Cell Biol. pmid:8389770
Sugiyama E et al. Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. 1993 J. Biochem. pmid:8514735
Wong K and Kwan-Yeung L Sphingosine mobilizes intracellular calcium in human neutrophils. 1993 Cell Calcium pmid:8358772
Dressler KA et al. Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells. 1991 J. Biol. Chem. pmid:2050663
Desai NN and Spiegel S Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines. 1991 Biochem. Biophys. Res. Commun. pmid:1958205
Sugiyama E et al. Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. 1990 Biochem. Biophys. Res. Commun. pmid:2357225
Ghosh TK et al. Intracellular calcium release mediated by sphingosine derivatives generated in cells. 1990 Science pmid:2163543
Strasberg PM and Callahan JW Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine. 1988 Biochem. Cell Biol. pmid:2977568
Sripada PK et al. Partial synthesis and properties of a series of N-acyl sphingomyelins. 1987 J. Lipid Res. pmid:3611973
Hara A and Taketomi T Detection of D-erythro and L-threo sphingosine bases in preparative sphingosylphosphorylcholine and its N-acylated derivatives and some evidence of their different chemical configurations. 1983 J. Biochem. pmid:6654881
Callahan JW et al. Studies on the hydrophobic properties of sphingomyelinase. 1981 Biochem. J. pmid:6272705
DAWSON RM The reported occurrence of sphingosylphosphorylcholine in animal tissues. 1958 Biochem. J. pmid:13522629
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