sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Jeong HS et al. Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects. 2011 J. Biomed. Sci. pmid:21838918
Park MK et al. Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. 2011 Biochim. Biophys. Acta pmid:21840417
Horii K et al. Development of a sphingosylphosphorylcholine detection system using RNA aptamers. 2010 Molecules pmid:20729797
Kudo R and Hatake K [Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery]. 2010 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:20681251
Sundh M et al. Influence of phase separating lipids on supported lipid bilayer formation at SiO2 surfaces. 2010 Phys Chem Chem Phys pmid:20023823
Choi H et al. Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:20230798
Kovacs E et al. Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling. 2010 J. Biol. Chem. pmid:19910470
Kim HJ et al. Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice. 2010 J. Dermatol. Sci. pmid:19889516
Kim DS et al. Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. 2010 J. Pharm. Pharmacol. pmid:20487197
Kovacs E et al. Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms. 2010 Biochem. Biophys. Res. Commun. pmid:20851108
Herzog C et al. Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. 2010 Mediators Inflamm. pmid:21274265
Choi SK et al. Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. 2009 Cardiovasc. Res. pmid:19218288
Andoh T et al. Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin. 2009 J. Invest. Dermatol. pmid:19657356
Wang HH et al. Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19234090
Aksu B et al. Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats. 2009 J. Pediatr. Surg. pmid:19361629
Imokawa G A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. 2009 J. Dermatol. Sci. pmid:19443184
Huwiler A and Pfeilschifter J Lipids as targets for novel anti-inflammatory therapies. 2009 Pharmacol. Ther. pmid:19576246
Kurokawa T et al. Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: a possible role as a spasmogen. 2009 J Clin Neurosci pmid:19596114
Ito M et al. Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava. 2009 J Oleo Sci pmid:19654457
Fox LM et al. Recognition of lyso-phospholipids by human natural killer T lymphocytes. 2009 PLoS Biol. pmid:19859526