sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with sphingosylphosphorylcholine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

Download all related citations
Per page 10 20 50 100 | Total 248
Authors Title Published Journal PubMed Link
Spangelo BL and Jarvis WD Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. 1996 Endocrinology pmid:8828503
Urs AN et al. Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. 2006 Endocrinology pmid:16887917
Rozengurt E and Rodríguez-Fernández JL Tyrosine phosphorylation in the action of neuropeptides and growth factors. 1997 Essays Biochem. pmid:9493012
Teisseyre A and Michalak K The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. 2004 Eur. Biophys. J. pmid:15014908
Törnquist K et al. Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells. 1997 Eur. J. Biochem. pmid:9346294
Jin Y et al. Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. 2005 Eur. J. Immunol. pmid:16078278
Chiulli N et al. Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease. 2007 Eur. J. Neurosci. pmid:17666077
Meyer zu Heringdorf D et al. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. 2001 Eur. J. Pharmacol. pmid:11239914
Kim HJ et al. Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632. 2008 Eur. J. Pharmacol. pmid:18289521
Park MK et al. Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12. 2016 Eur. J. Pharmacol. pmid:26872988
Meyer zu Heringdorf D et al. Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine. 1998 Eur. J. Pharmacol. pmid:9726638
Piao YJ et al. Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. 2005 Exp. Dermatol. pmid:15854129
Zhu MJ et al. Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts. 2005 Exp. Dermatol. pmid:15946238
Andoh T et al. Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions. 2011 Exp. Dermatol. pmid:21824199
Kim KH et al. Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells. 2012 Exp. Mol. Med. pmid:22127053
Kim KS et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. 2005 FASEB J. pmid:15857892
Mogami K et al. Sphingosylphosphorylcholine induces cytosolic Ca(2+) elevation in endothelial cells in situ and causes endothelium-dependent relaxation through nitric oxide production in bovine coronary artery. 1999 FEBS Lett. pmid:10471811
Uehara A et al. Effect of sphingosylphosphorylcholine on the single channel gating properties of the cardiac ryanodine receptor. 1999 FEBS Lett. pmid:10556518
Todoroki-Ikeda N et al. Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase. 2000 FEBS Lett. pmid:11018528
Miura Y et al. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. 2004 FEBS Lett. pmid:14741383
Xu D et al. Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts. 2007 FEBS Lett. pmid:17950286
Schwartz BM et al. Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. 2001 Gynecol. Oncol. pmid:11330965
Kamanna VS et al. Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease. 2005 Histol. Histopathol. pmid:15736064
Snetkov VA et al. Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. 2008 Hypertension pmid:18158336
Ceballos A et al. Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12. 2007 Immunology pmid:17371542
Moon HJ et al. Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells. 2007 Int. J. Biochem. Cell Biol. pmid:17481939
Zanglis A et al. The biological activity of acetylated sphingosylphosphorylcholine derivatives. 1996 Int. J. Biochem. Cell Biol. pmid:8624845
Oh JT et al. Quantification of the wound healing using polarization-sensitive optical coherence tomography. 2006 Jul-Aug J Biomed Opt pmid:16965152
Kurokawa T et al. Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: a possible role as a spasmogen. 2009 J Clin Neurosci pmid:19596114
Furuya S et al. Lysosphingomyelin-elicited Ca2+ mobilization from rat brain microsomes. 1996 J Lipid Mediat Cell Signal pmid:8906576
Ito M et al. Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava. 2009 J Oleo Sci pmid:19654457
Sugiyama E et al. Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. 1993 J. Biochem. pmid:8514735
Hara A and Taketomi T Detection of D-erythro and L-threo sphingosine bases in preparative sphingosylphosphorylcholine and its N-acylated derivatives and some evidence of their different chemical configurations. 1983 J. Biochem. pmid:6654881
Okajima F and Kondo Y Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. 1995 J. Biol. Chem. pmid:7592844
Nofer JR et al. Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. 2001 J. Biol. Chem. pmid:11432865
Ancellin N and Hla T Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. 1999 J. Biol. Chem. pmid:10383399
Zhu K et al. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. 2001 J. Biol. Chem. pmid:11535583
Murakami N et al. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. 2004 J. Biol. Chem. pmid:15280385
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. 2005 J. Biol. Chem. pmid:16498716
Kovacs E et al. Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling. 2010 J. Biol. Chem. pmid:19910470
Im DS et al. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. 2000 J. Biol. Chem. pmid:10799507
Deguchi H et al. Sphingolipids as bioactive regulators of thrombin generation. 2004 J. Biol. Chem. pmid:14722105
Sakagami H et al. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. 2005 J. Biol. Chem. pmid:15788404
Dressler KA et al. Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells. 1991 J. Biol. Chem. pmid:2050663
Okamoto H et al. EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. 1998 J. Biol. Chem. pmid:9765227
Arikawa K et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. 2003 J. Biol. Chem. pmid:12810709
Seufferlein T and Rozengurt E Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. 1995 J. Biol. Chem. pmid:7592646
Lai TS et al. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. 1997 J. Biol. Chem. pmid:9195933
Kim S et al. Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel. 1995 J. Biol. Chem. pmid:7890637
Rodríguez-Fernández JL and Rozengurt E Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells. 1998 J. Biol. Chem. pmid:9668122