sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Afrasiabi E et al. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. 2006 Cell. Signal. pmid:16490345
Czyborra C et al. Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521006
Retraction. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. 2006 Nat. Cell Biol. pmid:16508674
Katayama T et al. Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells. 2006 J. Pharmacol. Sci. pmid:17072099
Li S et al. Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16899767
Jeon ES et al. Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. 2006 J. Cell. Sci. pmid:17105765
Ryu SK et al. Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521007
Kim DS et al. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. 2006 Pigment Cell Res. pmid:16524430
Morikage N et al. Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. 2006 Circ. Res. pmid:16825579
Hemmings DG Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16570136
Jin Y et al. Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. 2005 Eur. J. Immunol. pmid:16078278
Suresh S et al. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. 2005 Acta Biomater pmid:16701777
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. 2005 J. Biol. Chem. pmid:16498716
Kamanna VS et al. Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease. 2005 Histol. Histopathol. pmid:15736064
Sakagami H et al. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. 2005 J. Biol. Chem. pmid:15788404
Mogi C et al. Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. 2005 J. Pharmacol. Sci. pmid:16210776
Im DS Two ligands for a GPCR, proton vs lysolipid. 2005 Acta Pharmacol. Sin. pmid:16297340
Jeon ES et al. Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways. 2005 Cell. Signal. pmid:15722202
Jeon ES et al. Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells. 2005 Biochim. Biophys. Acta pmid:15866480
Piao YJ et al. Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. 2005 Exp. Dermatol. pmid:15854129
Lu X and Bittman R Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. 2005 J. Org. Chem. pmid:15932314
Zhu MJ et al. Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts. 2005 Exp. Dermatol. pmid:15946238
van Diggelen OP et al. A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. 2005 J. Inherit. Metab. Dis. pmid:16151905
Schubert R Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue. 2005 Cardiovasc. Res. pmid:16111665
Kim KS et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. 2005 FASEB J. pmid:15857892
Thomas GD et al. Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. 2005 Cardiovasc. Res. pmid:15950201
Yagmurlu A et al. A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling. 2004 Pediatr. Surg. Int. pmid:15185106
Murakami N et al. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. 2004 J. Biol. Chem. pmid:15280385
Kostenis E Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands. 2004 J. Cell. Biochem. pmid:15258916
Kye KC et al. Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. 2004 J. Invest. Dermatol. pmid:15175025
Miura Y et al. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. 2004 FEBS Lett. pmid:14741383
Li Z et al. The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine. 2004 Chem. Phys. Lipids pmid:15172836
Deguchi H et al. Sphingolipids as bioactive regulators of thrombin generation. 2004 J. Biol. Chem. pmid:14722105
Teisseyre A and Michalak K The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. 2004 Eur. Biophys. J. pmid:15014908
Hedemann J et al. Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. 2004 Auton Autacoid Pharmacol pmid:15541015
Ignatov A et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. 2003 J. Neurosci. pmid:12574419
Yasukochi M et al. Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine. 2003 Pflugers Arch. pmid:12632186
Beil M et al. Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. 2003 Nat. Cell Biol. pmid:12942086
Suhr KB et al. Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. 2003 Arch. Dermatol. Res. pmid:12563540
Altmann C et al. Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. 2003 Br. J. Pharmacol. pmid:12569068
Okamoto R et al. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. 2003 J. Lipid Res. pmid:12518027
Altmann C et al. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. 2003 Br. J. Pharmacol. pmid:12522098
Higuchi K et al. Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes. 2003 Pigment Cell Res. pmid:14629725
Brailoiu E et al. Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). 2003 Biochem. J. pmid:12749764
Clair T et al. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. 2003 Cancer Res. pmid:14500380
Brailoiu E and Dun NJ Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings. 2003 Mol. Pharmacol. pmid:12761354
Arikawa K et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. 2003 J. Biol. Chem. pmid:12810709
Schnurbus R et al. Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine. 2002 Biochem. J. pmid:11829755
Neri LM et al. Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells. 2002 Mol. Biol. Cell pmid:11907274
Meyer zu Heringdorf D et al. Sphingosylphosphorylcholine-biological functions and mechanisms of action. 2002 Biochim. Biophys. Acta pmid:12069827