sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.
To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Niemann-Pick Disease, Type A | D052536 | 1 associated lipids |
| Niemann-Pick Disease, Type B | D052537 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hashiba Y et al. | Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. | 2007 | Neurol. Res. | pmid:17806208 |
| Rodriguez-Lafrasse C and Vanier MT | Sphingosylphosphorylcholine in Niemann-Pick disease brain: accumulation in type A but not in type B. | 1999 | Neurochem. Res. | pmid:9972865 |
| Yi H et al. | Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. | 2011 | Neurochem. Res. | pmid:21674237 |
| Czyborra C et al. | Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16521006 |
| Ryu SK et al. | Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16521007 |
| Hemmings DG | Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16570136 |
| Beil M et al. | Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. | 2003 | Nat. Cell Biol. | pmid:12942086 |
| Xu Y et al. | Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. | 2000 | Nat. Cell Biol. | pmid:10806476 |
| Retraction. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. | 2006 | Nat. Cell Biol. | pmid:16508674 | |
| Horii K et al. | Development of a sphingosylphosphorylcholine detection system using RNA aptamers. | 2010 | Molecules | pmid:20729797 |