sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Lu X and Bittman R Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. 2005 J. Org. Chem. pmid:15932314
Ignatov A et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. 2003 J. Neurosci. pmid:12574419
Higuchi K et al. Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes. 2001 J. Lipid Res. pmid:11590211
Okamoto R et al. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. 2003 J. Lipid Res. pmid:12518027
Bittman R and Verbicky CA Methanolysis of sphingomyelin. Toward an epimerization-free methodology for the preparation of D-erythro-sphingosylphosphocholine. 2000 J. Lipid Res. pmid:11108743
Xin C et al. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. 2007 J. Lipid Res. pmid:17592175
Jeon ES et al. Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. 2006 J. Lipid Res. pmid:16339111
Sripada PK et al. Partial synthesis and properties of a series of N-acyl sphingomyelins. 1987 J. Lipid Res. pmid:3611973
Sueyoshi N et al. Preparation of a naturally occurring D-erythro-(2S, 3R)-sphingosylphosphocholine using Shewanella alga NS-589. 1997 J. Lipid Res. pmid:9323602
Tokura Y et al. Modulation of T-lymphocyte proliferation by exogenous natural ceramides and sphingosylphosphorylcholine. 1999 J. Investig. Dermatol. Symp. Proc. pmid:10536997
Imokawa G et al. Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes. 1999 J. Invest. Dermatol. pmid:9886270
Kye KC et al. Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. 2004 J. Invest. Dermatol. pmid:15175025
Andoh T et al. Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin. 2009 J. Invest. Dermatol. pmid:19657356
Sun L et al. A new wound healing agent--sphingosylphosphorylcholine. 1996 J. Invest. Dermatol. pmid:8601721
Murata Y et al. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? 1996 J. Invest. Dermatol. pmid:8752664
Wakita H et al. Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes. 1998 J. Invest. Dermatol. pmid:9506444
van Diggelen OP et al. A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. 2005 J. Inherit. Metab. Dis. pmid:16151905
Lee HY et al. Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. 2011 J. Immunol. pmid:21368227
Takenouchi T et al. Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. 2008 J. Immunol. pmid:18523246
Kwon YB et al. Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. 2007 J. Dermatol. Sci. pmid:17321112