sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Snetkov VA et al. Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. 2008 Hypertension pmid:18158336
Miguel BG et al. Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C. 2008 Acta Neurobiol Exp (Wars) pmid:19112467
Kovacs E and Liliom K Sphingosylphosphorylcholine as a novel calmodulin inhibitor. 2008 Biochem. J. pmid:17979830
Nixon GF et al. The multi-functional role of sphingosylphosphorylcholine. 2008 Prog. Lipid Res. pmid:18042469
Murch O et al. Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. 2008 Crit. Care Med. pmid:18216604
Kim HJ et al. Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632. 2008 Eur. J. Pharmacol. pmid:18289521
Wang HH et al. Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18296570
Fujiwaki T et al. Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to tissues from patients with Niemann-Pick disease types A and C, and Gaucher disease. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18502707
Jeon ES et al. A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. 2008 Circ. Res. pmid:18688043
Takenouchi T et al. Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. 2008 J. Immunol. pmid:18523246
Shirao S et al. Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. 2008 Cerebrovasc. Dis. pmid:18511869
Brahmbhatt VV et al. Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. 2007 Chem. Phys. Lipids pmid:17126823
Hashiba Y et al. Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. 2007 Neurol. Res. pmid:17806208
Konno N et al. Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells. 2007 Biochem. Biophys. Res. Commun. pmid:17935698
Ceballos A et al. Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12. 2007 Immunology pmid:17371542
Xin C et al. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. 2007 J. Lipid Res. pmid:17592175
Kleger A et al. The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. 2007 Cell. Signal. pmid:16978842
Jeon ES et al. Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK. 2007 J. Cell. Biochem. pmid:17131361
Michel MC et al. Vascular effects of sphingolipids. 2007 Acta Paediatr Suppl pmid:17391441
Mulders AC et al. Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. 2007 Auton Autacoid Pharmacol pmid:18076478